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Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique

  • Authors:
    • Tian Tang
    • Duan‑Lian Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2937-2944
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    Published online on: March 13, 2017
       https://doi.org/10.3892/ol.2017.5856
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Abstract

Hemangioma is one of the most common types of infantile vascular benign tumor. The aim of the present study was to investigate the role of B-cell lymphoma 2 (Bcl-2) and tumor protein p53 (p53) in the proliferation and apoptosis of hemangioma cells. A total of 38 paraffin‑embedded hemangioma specimens (16 males and 22 females) and another 5 paraffin‑embedded healthy surrounding tissue samples, collected between January 2007 and December 2010, were obtained from the Department of Pathology at Renmin Hospital of Wuhan University (Wuhan, China). Immunohistochemistry, hematoxylin and eosin staining, and quantum dot double staining were used to detect the expression of proliferating cell nuclear antigen (PCNA), Bcl‑2 and p53 in hemangioma and healthy surrounding skin tissue samples. All hemangioma specimens were classified into proliferative or the involuting stage hemangioma according to Mulliken's criteria and their expression of PCNA. The results of the quantum dot double staining were analyzed using a multi‑spectral imaging system. One-way analysis of the variance and the Student‑Newman‑Keuls q test were performed to statistically analyze the data. There were 24 cases of proliferative stage and 14 cases of involuting stage hemangioma among the specimens. Immunohistochemical analysis results indicated a high expression of Bcl‑2 and p53 in proliferative stage hemangioma tissue samples, and low expression in involuting stage hemangioma and healthy tissue samples. Statistical analysis of the results from quantum dot double staining demonstrated that the expression of Bcl‑2 and p53 in proliferative hemangioma was significantly increased compared with that in involuting stage specimens (P<0.05) and healthy tissue samples (P<0.05). No significant difference in Bcl‑2 and p53 expression was identified between the involuting hemangioma and healthy surrounding tissue samples. The higher expression of Bcl‑2 and p53 in proliferative hemangioma suggests that Bcl‑2 may cause an imbalance between endothelial cell proliferation and apoptosis through the inhibition of endothelial cell apoptosis. Furthermore, p53 may promote the proliferation of endothelial cells in proliferative hemangioma.
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1 

Kilcline C and Frieden IJ: Infantile hemangiomas: How common are they? A systematic review of the medical literature. Pediatr Dermatol. 25:168–173. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Takahashi K, Mulliken JB, Kozakewich HP, Rogers RA, Folkman J and Ezekowitz RA: Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest. 93:2357–2364. 1994. View Article : Google Scholar : PubMed/NCBI

3 

Mulliken JB and Young AE: Vascular birthmarks: Hemangiomas and malformations. W. B. Saunders Co.; Philadelphia: 1988

4 

Risau W and Flamme I: Vasculogenesis. Annu Rev Cell Dev Biol. 11:73–91. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Risau W: Mechanisms of angiogenesis. Nature. 386:671–674. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Flamme I, Frölich T and Risau W: Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J Cell Physiol. 173:206–210. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Carmeliet P: Angiogenesis in health and disease. Nat Med. 9:653–660. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1:27–31. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Brandling-Bennett HA, Metry DW, Baselga E, Lucky AW, Adams DM, Cordisco MR and Frieden IJ: Infantile hemangiomas with unusually prolonged growth phase: A case series. Arch Dermatol. 144:1632–1637. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Stiles J, Amaya C, Pham R, Rowntree RK, Lacaze M, Mulne A, Bischoff J, Kokta V, Boucheron LE, Mitchell DC and Bryan BA: Propranolol treatment of infantile hemangioma endothelial cells: A molecular analysis. Exp Ther Med. 4:594–604. 2012.PubMed/NCBI

11 

Bourdelat D, Melki E, Mazzola C and Marreel A: Congenital prenatal hemangioma: Diagnosis and treatment. Arch Pediatr. 17:383–386. 2010.(In French). View Article : Google Scholar : PubMed/NCBI

12 

Yuan WL, Qin XJ and Wang XK: Expression and correlation of mast cell, Clusterin/apoJ and transforming growth factor-beta in the different stages of human dermal hemangioma. Hua Xi Kou Qiang Yi Xue Za Zhi. 27:361–365. 2009.(In Chinese). PubMed/NCBI

13 

Chang J, Most D, Bresnick S, Mehrara B, Steinbrech DS, Reinisch J, Longaker MT and Turk AE: Proliferative hemangiomas: Analysis of cytokine gene expression and angiogenesis. Plast Reconstr Surg. 103:1–10. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Tan ST, Wallis RA, He Y and Davis PF: Mast cells and hemangioma. Plast Reconstr Surg. 113:999–1011. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Shan S, Shan G and Zhang D: Treatment of hemangioma by transfection of antisense VEGF gene. J Huazhong Univ Sci Technolog Med Sci. 29:335–339. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Shan G, Tang T and Zhang D: Expression of HLA-G in hemangioma and its clinical significance. J Huazhong Univ Sci Technolog Med Sci. 32:713–718. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Razon MJ, Kräling BM, Mulliken JB and Bischoff J: Increased apoptosis coincides with onset of involution in infantile hemangioma. Microcirculation. 5:189–195. 1998. View Article : Google Scholar : PubMed/NCBI

18 

Cook BD, Ferrari G, Pintucci G and Mignatti P: TGF-beta1 induces rearrangement of FLK-1-VE-cadherin-beta-catenin complex at the adherens junction through VEGF-mediated signaling. J Cell Biochem. 105:1367–1373. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Sharma MR, Tuszynski GP and Sharma MC: Angiostatin-induced inhibition of endothelial cell proliferation/apoptosis is associated with the down-regulation of cell cycle regulatory protein cdk5. J Cell Biochem. 91:398–409. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Ola MS, Nawaz M and Ahsan H: Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Mol Cell Biochem. 351:41–58. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Tobiume K: Involvement of Bcl-2 family proteins in p53-induced apoptosis. J Nippon Med Sch. 72:192–193. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Vaseva AV and Moll UM: The mitochondrial p53 pathway. Biochim Biophys Acta. 1787:414–420. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Crowe DL and Sinha UK: P53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines. Head Neck. 28:15–23. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Hainaut P: The tumor suppressor protein p53: A receptor to genotoxic stress that controls cell growth and survival. Curr Opin Oncol. 7:76–82. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Han Z, Chatterjee D, He DM, Early J, Pantazis P, Wyche JH and Hendrickson EA: Evidence for a G2 checkpoint in p53-independent apoptosis induction by X-irradiation. Mol Cell Biol. 15:5849–5857. 1995. View Article : Google Scholar : PubMed/NCBI

26 

Marinaş MC, Mogoş DG, Simionescu CE, Stepan A and Tănase F: The study of p53 and p16 immunoexpression in serous borderline and malignant ovarian tumors. Rom J Morphol Embryol. 53:1021–1025. 2012.PubMed/NCBI

27 

Cheok CF and Lane DP: Seeking synergy in p53 transcriptional activation for cancer therapy. Discov Med. 14:263–271. 2012.PubMed/NCBI

28 

Jayaraman B, Valiathan GM, Jayakumar K, Palaniyandi A, Thenumgal SJ and Ramanathan A: Lack of mutation in p53 and H-ras genes in phenytoin induced gingival overgrowth suggests its non cancerous nature. Asian Pac J Cancer Prev. 13:5535–5538. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Martina JD, Simmons C and Jukic DM: High-definition hematoxylin and eosin staining in a transition to digital pathology. J Pathol Inform. 2:452011. View Article : Google Scholar : PubMed/NCBI

30 

Mulliken JB and Glowacki J: Hemangiomas and vascular malformations in infants and children: A classification based on endothelial characteristics. Plast Reconstr Surg. 69:412–422. 1982. View Article : Google Scholar : PubMed/NCBI

31 

Tomek M, Akiyama T and Dass CR: Role of Bcl-2 in tumour cell survival and implications for pharmacotherapy. J Pharm Pharmacol. 64:1695–1702. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Xiao Z, Shan J, Li C, Luo L, Lu J, Li S, Long D and Li Y: Mechanisms of cyclosporine-induced renal cell apoptosis: A systematic review. Am J Nephrol. 37:30–40. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Sermeus A, Genin M, Maincent A, Fransolet M, Notte A, Leclere L, Riquier H, Arnould T and Michiels C: Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types. PLoS One. 7:e475192012. View Article : Google Scholar : PubMed/NCBI

34 

Shu R, Liu DL and Wang Q: Effect of remifentanil on expression of Bcl-2 and caspase-3 in ratscerebral cortex following Ischemia-reperfusion injury. Acta Medicinae Universitatis Scientiae et Technologiae Huazhong. 41:72–75. 2012.(In Chinese).

35 

Tsujimoto Y, Finger LR, Yunis J, Nowell PC and Croce CM: Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science. 226:1097–1099. 1984. View Article : Google Scholar : PubMed/NCBI

36 

McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP and Korsmeyer SJ: bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 57:79–88. 1989. View Article : Google Scholar : PubMed/NCBI

37 

Turner HE, Nagy Z, Gatter KC, Esiri MM, Wass JA and Harris AL: Proliferation, bcl-2 expression and angiogenesis in pituitary adenomas: Relationship to tumour behaviour. Br J Cancer. 82:1441–1445. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Gazzaniga P, Gandini O, Gradilone A, Silvestri I, Giuliani L, Magnanti M, Gallucci M, Saccani G, Frati L and Agliano AM: Detection of basic fibroblast growth factor mRNA in urinary bladder cancer: Correlation with local relapses. Int J Oncol. 14:1123–1127. 1999.PubMed/NCBI

39 

Bielenberg DR, Bucana CD, Sanchez R, Mulliken JB, Folkman J and Fidler IJ: Progressive growth of infantile cutaneous hemangiomas is directly correlated with hyperplasia and angiogenesis of adjacent epidermis and inversely correlated with expression of the endogenous angiogenesis inhibitor, IFN-beta. Int J Oncol. 14:401–408. 1999.PubMed/NCBI

40 

Halasi M, Pandit B and Gartel AL: Proteasome inhibitors suppress the protein expression of mutant p53. Cell Cycle. 13:3202–3206. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Giurgea LN, Ungureanu C and Mihailovici MS: The immunohistochemical expression of p53 and Ki67 in ovarian epithelial borderline tumors. Correlation with clinicopathological factors. Rom J Morphol Embryol. 53:967–973. 2012.PubMed/NCBI

42 

Rao Z and Ding Y: Ubiquitin pathway and ovarian cancer. Curr Oncol. 19:324–328. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Ji Y, Li K, Xiao X, Zheng S, Xu T and Chen S: Effects of propranolol on the proliferation and apoptosis of hemangioma-derived endothelial cells. J Pediatr Surg. 47:2216–2223. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Porter PL, Gown AM, Kramp SG and Coltrera MD: Widespread p53 overexpression in human malignant tumors. An immunohistochemical study using methacarn-fixed, embedded tissue. Am J Pathol. 140:145–153. 1992.PubMed/NCBI

45 

Itahana Y and Itahana K: Emerging roles of mitochondrial p53 and ARF. Curr Drug Targets. 13:1633–1640. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Crasta JA, Mishra S and Vallikad E: Ovarian serous carcinoma: Relationship of p53 and bcl-2 with tumor angiogenesis and VEGF expression. Int J Gynecol Pathol. 30:521–526. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Kang SM, Maeda K, Onoda N, Chung YS, Nakata B, Nishiguchi Y and Sowa M: Combined analysis of p53 and vascular endothelial growth factor expression in colorectal carcinoma for determination of tumor vascularity and liver metastasis. Int J Cancer. 74:502–507. 1997. View Article : Google Scholar : PubMed/NCBI

48 

Koide N, Nishio A, Hiraguri M, Hanazaki K, Adachi W and Amano J: Coexpression of vascular endothelial growth factor and p53 protein in squamous cell carcinoma of the esophagus. Am J Gastroenterol. 96:1733–1740. 2001. View Article : Google Scholar : PubMed/NCBI

49 

Tian Y, Ding RY, Zhi YH, Guo RX and Wu SD: Analysis of p53 and vascular endothelial growth factor expression in human gallbladder carcinoma for the determination of tumor vascularity. World J Gastroenterol. 12:415–419. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tang T and Zhang DL: Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique. Oncol Lett 13: 2937-2944, 2017.
APA
Tang, T., & Zhang, D. (2017). Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique. Oncology Letters, 13, 2937-2944. https://doi.org/10.3892/ol.2017.5856
MLA
Tang, T., Zhang, D."Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique". Oncology Letters 13.5 (2017): 2937-2944.
Chicago
Tang, T., Zhang, D."Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique". Oncology Letters 13, no. 5 (2017): 2937-2944. https://doi.org/10.3892/ol.2017.5856
Copy and paste a formatted citation
x
Spandidos Publications style
Tang T and Zhang DL: Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique. Oncol Lett 13: 2937-2944, 2017.
APA
Tang, T., & Zhang, D. (2017). Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique. Oncology Letters, 13, 2937-2944. https://doi.org/10.3892/ol.2017.5856
MLA
Tang, T., Zhang, D."Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique". Oncology Letters 13.5 (2017): 2937-2944.
Chicago
Tang, T., Zhang, D."Detection of p53 and Bcl-2 expression in cutaneous hemangioma through the quantum dot technique". Oncology Letters 13, no. 5 (2017): 2937-2944. https://doi.org/10.3892/ol.2017.5856
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