IL-35 expression is increased in laryngeal squamous cell carcinoma and in the peripheral blood of patients

  • Authors:
    • Wei Wu
    • Hua Jiang
    • Ying Li
    • Mao‑Xiao Yan
  • View Affiliations

  • Published online on: March 14, 2017     https://doi.org/10.3892/ol.2017.5858
  • Pages: 3303-3308
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Abstract

Interleukin-35 (IL-35) has been proposed as a novel immune-suppressing cytokine. However, the function of IL-35 in malignant diseases is yet to be elucidated. The present study investigated IL‑35 expression levels in laryngeal squamous cell carcinoma (LSCC) tissues and the peripheral blood of patients to explore the potential involvement of IL‑35 in LSCC progression. In the present study, IL‑35 expression levels in tissues and peripheral blood were analyzed by reverse transcription‑quantitative polymerase chain reaction and an enzyme‑linked immunosorbent assay. The association between IL‑35 expression levels and clinical characteristics was also evaluated. The present results demonstrated that IL‑35 expression in tumor tissues was significantly higher than in adjacent normal tissues, and a significant association between IL‑35 expression levels in tissues and the tumor site was detected. Furthermore, the expression of IL‑35 in the peripheral blood of patients was significantly decreased subsequent to tumor resection. No correlation between peripheral blood IL‑35 expression and clinical characteristics was detected. In conclusion, the present study demonstrated that IL‑35 is highly expressed in LSCC tissues and in the peripheral blood of patients with LSCC. There was a notable, significant reduction of peripheral blood IL‑35 expression following surgical resection of tumors. These results may be useful for diagnostic or therapeutic purposes in patients with LSCC.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wu W, Jiang H, Li Y and Yan MX: IL-35 expression is increased in laryngeal squamous cell carcinoma and in the peripheral blood of patients. Oncol Lett 13: 3303-3308, 2017
APA
Wu, W., Jiang, H., Li, Y., & Yan, M. (2017). IL-35 expression is increased in laryngeal squamous cell carcinoma and in the peripheral blood of patients. Oncology Letters, 13, 3303-3308. https://doi.org/10.3892/ol.2017.5858
MLA
Wu, W., Jiang, H., Li, Y., Yan, M."IL-35 expression is increased in laryngeal squamous cell carcinoma and in the peripheral blood of patients". Oncology Letters 13.5 (2017): 3303-3308.
Chicago
Wu, W., Jiang, H., Li, Y., Yan, M."IL-35 expression is increased in laryngeal squamous cell carcinoma and in the peripheral blood of patients". Oncology Letters 13, no. 5 (2017): 3303-3308. https://doi.org/10.3892/ol.2017.5858