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Article

Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup

  • Authors:
    • Antonio Ieni
    • Valeria Barresi
    • Luana Licata
    • Roberta Cardia
    • Carmine Fazzari
    • Giuseppe Nuciforo
    • Francesco Caruso
    • Michele Caruso
    • Vincenzo Adamo
    • Giovanni Tuccari
  • View Affiliations / Copyright

    Affiliations: Department of Human Pathology of Adult and Evolutive Age ‘Gaetano Barresi’, Polyclinic ‘G. Martino’, University of Messina, I‑98125 Messina, Italy, Department of Pathological Anatomy, Humanitas Catanese Center of Oncology, I‑95126 Catania, Italy, Department of Oncological Surgery, Humanitas Catanese Center of Oncology, I‑95126 Catania, Italy, Department of Oncology, Humanitas Catanese Center of Oncology, I‑95126 Catania, Italy
  • Pages: 3205-3209
    |
    Published online on: March 14, 2017
       https://doi.org/10.3892/ol.2017.5859
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Abstract

Triple-negative breast cancer (TNBC) indicates a subset of breast carcinomas that does not express estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor‑2 (HER2). According to the literature, TNBCs are aggressive tumors, characterized by a high incidence of recurrence and a high risk of disease progression. Lactoferrin (LF) is a single‑chain, iron‑binding glycoprotein of ~700 amino acids, which is involved in a wide range of biological activities, including iron‑trafficking and carcinogenesis. The present study aimed to assess LF expression in human TNBC samples and the possible correlation with clinico‑pathological parameters associated with biological aggressiveness. LF immunohistochemical expression was investigated in formalin‑fixed, paraffin‑embedded samples of human TNBC. Cases were analyzed according to an intensity distribution (ID) score, and only those showing an ID score of >2 were considered as positive for LF. LF immunostaining was encountered in 26.15% cases. A significant correlation was found between LF expression and a low Ki‑67 labeling index (P=0.040), the absence of recurrence (P=0.010) and alive status (P=0.020). LF may assist in identifying a subset of TNBC with less aggressive biological behavior. The meaning of LF expression in TNBC remains unclear and is controversial. The present findings indicated that LF expression is correlated with a low growth fraction in these tumors. Thus, it is possible that the inhibition of the LF axis may be a valid therapeutic target for TNBC, and this should be confirmed by future studies.
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Copy and paste a formatted citation
Spandidos Publications style
Ieni A, Barresi V, Licata L, Cardia R, Fazzari C, Nuciforo G, Caruso F, Caruso M, Adamo V, Tuccari G, Tuccari G, et al: Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup. Oncol Lett 13: 3205-3209, 2017.
APA
Ieni, A., Barresi, V., Licata, L., Cardia, R., Fazzari, C., Nuciforo, G. ... Tuccari, G. (2017). Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup. Oncology Letters, 13, 3205-3209. https://doi.org/10.3892/ol.2017.5859
MLA
Ieni, A., Barresi, V., Licata, L., Cardia, R., Fazzari, C., Nuciforo, G., Caruso, F., Caruso, M., Adamo, V., Tuccari, G."Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup". Oncology Letters 13.5 (2017): 3205-3209.
Chicago
Ieni, A., Barresi, V., Licata, L., Cardia, R., Fazzari, C., Nuciforo, G., Caruso, F., Caruso, M., Adamo, V., Tuccari, G."Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup". Oncology Letters 13, no. 5 (2017): 3205-3209. https://doi.org/10.3892/ol.2017.5859
Copy and paste a formatted citation
x
Spandidos Publications style
Ieni A, Barresi V, Licata L, Cardia R, Fazzari C, Nuciforo G, Caruso F, Caruso M, Adamo V, Tuccari G, Tuccari G, et al: Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup. Oncol Lett 13: 3205-3209, 2017.
APA
Ieni, A., Barresi, V., Licata, L., Cardia, R., Fazzari, C., Nuciforo, G. ... Tuccari, G. (2017). Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup. Oncology Letters, 13, 3205-3209. https://doi.org/10.3892/ol.2017.5859
MLA
Ieni, A., Barresi, V., Licata, L., Cardia, R., Fazzari, C., Nuciforo, G., Caruso, F., Caruso, M., Adamo, V., Tuccari, G."Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup". Oncology Letters 13.5 (2017): 3205-3209.
Chicago
Ieni, A., Barresi, V., Licata, L., Cardia, R., Fazzari, C., Nuciforo, G., Caruso, F., Caruso, M., Adamo, V., Tuccari, G."Immunoexpression of lactoferrin in triple-negative breast cancer patients: A proposal to select a less aggressive subgroup". Oncology Letters 13, no. 5 (2017): 3205-3209. https://doi.org/10.3892/ol.2017.5859
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