Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer

  • Authors:
    • Bartosz Adam Frycz
    • Dawid Murawa
    • Maciej Borejsza‑Wysocki
    • Mateusz Wichtowski
    • Arkadiusz Spychała
    • Ryszard Marciniak
    • Paweł Murawa
    • Michał Drews
    • Paweł Piotr Jagodziński
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 60‑781 Poznań, Poland, First Department of Surgical Oncology and General Surgery, Greater Poland Cancer Centre, 61‑866 Poznań, Poland, Department of General and Endocrine Surgery and Gastroenterological Oncology, Heliodor Święcicki Clinical Hospital, Poznań University of Medical Sciences, 60‑355 Poznań, Poland
    Copyright: © Frycz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3369-3378
    |
    Published online on: March 21, 2017
       https://doi.org/10.3892/ol.2017.5881
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Epidemiological and experimental findings suggest that the development of gastric cancer (GC) is regulated by steroid hormones. In postmenopausal women and older men, the majority of steroid hormones are produced locally in peripheral tissue through the enzymatic conversion of steroid precursors. Therefore, using reverse transcription‑quantitative polymerase chain reaction analysis, the mRNA expression of genes encoding steroidogenic enzymes, including steroid sulfatase (STS), hydroxy-delta-5-steroid dehydrogenase 3 beta- and steroid delta-isomerase 1 (HSD3B1), 17β-hydroxysteroid dehydrogenase type 7 and aromatase (CYP19A1), was investigated in primary tumoral and adjacent healthy gastric mucosa from 60 patients with GC. Furthermore, the mRNA levels for estrogen receptor α, estrogen receptor β (ESR2) and androgen receptor (AR), along with their coregulators, including proline, glutamate and leucine rich protein 1, CREB binding protein, nuclear receptor coactivator 1 (NCOA1), nuclear receptor corepressor 1 (NCOR1) and nuclear receptor subfamily 2 group F member 1 (NR2F1), were investigated. Additionally, the association between the mRNA expression of these genes and the clinicopathological features of patients with GC was examined. Significantly decreased levels of STS, HSD3B1, ESR2, AR, NCOA1 and NCOR1 mRNA, in addition to significantly increased levels of CYP19A1 mRNA were demonstrated in tumoral tissue samples compared with adjacent healthy gastric tissue samples. Deregulated expression of these genes in the analyzed tissue samples was associated with certain clinicopathological features of GC, such as age and localization of the tumor. The results of the current study suggest that all of the genes analyzed are expressed in tumoral and adjacent healthy gastric mucosa. In addition, the results indicate that abnormal expression of STS, ESR2, AR, NCOA1 and NCOR1 may serve a role in the development and progression of GC, and may be associated with specific clinicopathological features in patients with GC.
View Figures

Figure 1

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Karimi P, Islami F, Anandasabapathy S, Freedman ND and Kamangar F: Gastric cancer: Descriptive epidemiology, risk factors, screening and prevention. Cancer Epidemiol Biomarkers Prev. 23:700–713. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Sipponen P and Correa P: Delayed rise in incidence of gastric cancer in females results in unique sex ratio (M/F) pattern: Etiologic hypothesis. Gastric Cancer. 5:213–219. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Hogan AM, Collins D, Baird AW and Winter DC: Estrogen and gastrointestinal malignancy. Mol Cell Endocrinol. 307:19–24. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Camargo MC, Goto Y, Zabaleta J, Morgan DR, Correa P and Rabkin CS: Sex hormones, hormonal interventions, and gastric cancer risk: A meta-analysis. Cancer Epidemiol Biomarkers Prev. 21:20–38. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Lindblad M, Ye W, Rubio C and Lagergren J: Estrogen and risk of gastric cancer: A protective effect in a nationwide cohort study of patients with prostate cancer in Sweden. Cancer Epidemiol Biomarkers Prev. 13:2203–2207. 2004.PubMed/NCBI

7 

Nylander-Koski O, Kiviluoto T, Puolakkainen P, Kivilaakso E and Mustonen H: The effect of nitric oxide, growth factors, and estrogen on gastric cell migration. J Surg Res. 143:230–237. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Ohtani M, García A, Rogers AB, Ge Z, Taylor NS, Xu S, Watanabe K, Marini RP, Whary MT, Wang TC and Fox JG: Protective role of 17 beta-estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice. Carcinogenesis. 28:2597–2604. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Chandanos E and Lagergren J: Oestrogen and the enigmatic male predominance of gastric cancer. Eur J Cancer. 44:2397–2403. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Duell EJ, Travier N, Lujan-Barroso L, Boutron-Ruault MC, Clavel-Chapelon F, Palli D, Krogh V, Mattiello A, Tumino R, Sacerdote C, et al: Menstrual and reproductive factors, exogenous hormone, use and gastric cancer risk in a cohort of women from the European Prospective Investigation Into Cancer and Nutrition. Am J Epidemiol. 172:1384–1393. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Ohtani M, Ge Z, García A, Rogers AB, Muthupalani S, Taylor NS, Xu S, Watanabe K, Feng Y, Marini RP, et al: 17 β-estradiol suppresses Helicobacter pylori-induced gastric pathology in male hypergastrinemic INS-GAS mice. Carcinogenesis. 32:1244–1250. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Sheh A, Ge Z, Parry NM, Muthupalani S, Rager JE, Raczynski AR, Mobley MW, McCabe AF, Fry RC, Wang TC and Fox JG: 17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice. Cancer Prev Res (Phila). 4:1426–1435. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Simpson ER: Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 86:225–230. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Labrie F: All sex steroids are made intracellularly in peripheral tissue by the mechanisms of intracrinology after menopause. J Steroid Biochem Mol Biol. 145:133–138. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Frycz BA, Murawa D, Wysocki-Borejsza M, Marciniak R, Murawa P, Drews M and Jagodziński PP: Expression of 17β-hydroxysteroid dehydrogenase type 1 in gastric cancer. Biomed Pharmacother. 67:651–657. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Frycz BA, Murawa D, Borejsza-Wysocki M, Marciniak R, Murawa P, Drews M and Jagodziński PP: Expression of 17β-hydroxysteroid dehydrogenase type 2 is associated with some clinicopathological features in gastric cancer. Biomed Pharmacother. 70:24–27. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Frycz BA, Murawa D, Borejsza-Wysocki M, Wichtowski M, Spychała A, Marciniak R, Murawa P, Drews M and Jagodziński PP: Transcript level of AKR1C3 is down-regulated in gastric cancer. Biochem Cell Biol. 94:138–146. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Gan L, He J, Zhang X, Zhang YJ, Yu GZ, Chen Y, Pan J, Wang JJ and Wang X: Expression profile and prognostic role of sex hormone receptors in gastric cancer. BMC Cancer. 12:5662012. View Article : Google Scholar : PubMed/NCBI

19 

Tian Y, Wan H, Lin Y, Xie X, Li Z and Tan G: Androgen receptor may be responsible for gender disparity in gastric cancer. Med Hypotheses. 80:672–674. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Chomczynski P and Sacchi N: The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on. Nat Protoc. 1:581–585. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Tellmann G: The E-Method: A highly accurate technique for gene-expression analysis. Nature methods. 3:i–ii. 2006. View Article : Google Scholar

22 

Hashimoto T, Bazmi HH, Mirnics K, Wu Q, Sampson AR and Lewis DA: Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry. 165:479–489. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Rawłuszko AA, Antoniucci M, Horbacka K, Lianeri M, Krokowicz P and Jagodziński PP: Reduced expression of steroid sulfatase in primary colorectal cancer. Biomed Pharmacother. 67:577–582. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Ruder HJ, Loriaux L and Lipsett MB: Estrone sulfate: Production rate and metabolism in man. J Clin Invest. 51:1020–1033. 1972. View Article : Google Scholar : PubMed/NCBI

25 

Labrie F: Extragonadal synthesis of sex steroids: Intracrinology. Ann Endocrinol (Paris). 64:95–107. 2003.PubMed/NCBI

26 

Secky L, Svoboda M, Klameth L, Bajna E, Hamilton G, Zeillinger R, Jäger W and Thalhammer T: The sulfatase pathway for estrogen formation: Targets for the treatment and diagnosis of hormone-associated tumors. J Drug Deliv. 2013:9576052013. View Article : Google Scholar : PubMed/NCBI

27 

Chetrite GS, Cortes-Prieto J, Philippe JC, Wright F and Pasqualini JR: Comparison of estrogen concentrations, estrone sulfatase and aromatase activities in normal, and in cancerous, human breast tissue samples. J Steroid Biochem Mol Biol. 72:23–27. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Utsumi T, Yoshimura N, Takeuchi S, Maruta M, Maeda K and Harada N: Elevated steroid sulfatase expression in breast cancers. J Steroid Biochem Mol Biol. 73:141–145. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Miyoshi Y, Ando A, Hasegawa S, Ishitobi M, Taguchi T, Tamaki Y and Noguchi S: High expression of steroid sulfatase mRNA predicts poor prognosis in patients with estrogen receptor-positive breast cancer. Clin Cancer Res. 9:2288–2293. 2003.PubMed/NCBI

30 

Suzuki T, Miki Y, Nakata T, Shiotsu Y, Akinaga S, Inoue K, Ishida T, Kimura M, Moriya T and Sasano H: Steroid sulfatase and estrogen sulfotransferase in normal human tissue and breast carcinoma. J Steroid Biochem Mol Biol. 86:449–454. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Poisson Paré D, Song D, Luu-The V, Han B, Li S, Liu G, Labrie F and Pelletier G: Expression of estrogen sulfotransferase 1E1 and steroid sulfatase in breast cancer: A immunohistochemical study. Breast Cancer (Auckl). 3:9–21. 2009.PubMed/NCBI

32 

Suzuki M, Ishida H, Shiotsu Y, Nakata T, Akinaga S, Takashima S, Utsumi T, Saeki T and Harada N: Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients. J Steroid Biochem Mol Biol. 113:195–201. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Hanamura T, Niwa T, Gohno T, Kurosumi M, Takei H, Yamaguchi Y, Ito K and Hayashi S: Possible role of the aromatase-independent steroid metabolism pathways in hormone responsive primary breast cancers. Breast Cancer Res Treat. 143:69–80. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Khvostova EP, Otpuschennikov AA, Pustylnyak VO and Gulyaeva LF: Gene expression of androgen metabolising enzymes in benign and malignant prostatic tissues. Horm Metab Res. 47:119–124. 2015.PubMed/NCBI

35 

Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, Higano CS, True LD and Nelson PS: Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth. Cancer Res. 68:4447–4454. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Chang KH, Ercole CE and Sharifi N: Androgen metabolism in prostate cancer: From molecular mechanisms to clinical consequences. Br J Cancer. 111:1249–1254. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Saitoh Y, Sasano H, Naganuma H, Ohtani H, Sasano N, Ohuchi A and Matsuno S: De novo expression of aromatase in gastric carcinoma. Light and electron microscopic immunohistochemical and immunoblot study. Pathol Res Pract. 188:53–60. 1992. View Article : Google Scholar : PubMed/NCBI

38 

Izawa M, Inoue M, Osaki M, Ito H, Harada T, Terakawa N and Ikeguchi M: Cytochrome P450 aromatase gene (CYP19) expression in gastric cancer. Gastric Cancer. 11:103–110. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Ueyama T, Shirasawa N, Numazawa M, Yamada K, Shelangouski M, Ito T and Tsuruo Y: Gastric parietal cells: Potent endocrine role in secreting estrogen as a possible regulator of gastro-hepatic axis. Endocrinology. 143:3162–3170. 2002. View Article : Google Scholar : PubMed/NCBI

40 

Ueyama T, Shirasawa N, Ito T and Tsuruo Y: Estrogen-producing steroidogenic pathways in parietal cells of the rat gastric mucosa. Life Sci. 74:2327–2337. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Kobayashi H, Yoshida S, Sun YJ, Shirasawa N and Naito A: 17β-Estradiol in the systemic circulation derives mainly from the parietal cells in cholestatic female rats. J Endocrinol Invest. 39:389–400. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Ozawa M, Takahashi K, Akazawa KH, Takashima T, Nagata H, Doi H, Hosoya T, Wada Y, Cui Y, Kataoka Y and Watanabe Y: PET of aromatase in gastric parietal cells using 11C-vorozole. J Nucl Med. 52:1964–1969. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Kobayashi H, Yoshida S, Sun YJ, Shirasawa N and Naito A: Postnatal development of gastric aromatase and portal venous estradiol-17β levels in male rats. J Endocrinol. 218:117–124. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Kobayashi H, Yoshida S, Sun YJ, Shirasawa N and Naito A: Gastric estradiol-17β (E2) and liver ERα correlate with serum E2 in the cholestatic male rat. J Endocrinol. 219:39–49. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Pasqualini JR and Chetrite G: Paradoxical effect of estradiol: It can block its own bioformation in human breast cancer cells. J Steroid Biochem Mol Biol. 78:21–24. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Pasqualini JR and Chetrite GS: Estradiol as an anti-aromatase agent in human breast cancer cells. J Steroid Biochem Mol Biol. 98:12–17. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Levin ER: Extranuclear steroid receptors are essential for steroid hormone actions. Annu Rev Med. 66:271–280. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Rahman Ur MS and Cao J: Estrogen receptors in gastric cancer: Advances and perspectives. World J Gastroenterol. 22:2475–2482. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Hayashi SI, Eguchi H, Tanimoto K, Yoshida T, Omoto Y, Inoue A, Yoshida N and Yamaguchi Y: The expression and function of estrogen receptor alpha and beta in human breast cancer and its clinical application. Endocr Relat Cancer. 10:193–202. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Shanle EK and Xu W: Selectively targeting estrogen receptors for cancer treatment. Adv Drug Deliv Rev. 62:1265–1276. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Xie LQ, Yu JP and Luo HS: Expression of estrogen receptor beta in human colorectal cancer. World J Gastroenterol. 10:214–217. 2004.PubMed/NCBI

52 

Risbridger GP, Davis ID, Birrell SN and Tilley WD: Breast and prostate cancer: More similar than different. Nat Rev Cancer. 10:205–212. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Chandanos E, Rubio CA, Lindblad M, Jia C, Tsolakis AV, Warner M, Gustafsson JA and Lagergren J: Endogenous estrogen exposure in relation to distribution of histological type and estrogen receptors in gastric adenocarcinoma. Gastric Cancer. 11:168–174. 2008. View Article : Google Scholar : PubMed/NCBI

54 

Kameda C, Nakamura M, Tanaka H, Yamasaki A, Kubo M, Tanaka M, Onishi H and Katano M: Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. Br J Cancer. 102:738–747. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Xu CY, Guo JL, Jiang ZN, Xie SD, Shen JG, Shen JY and Wang LB: Prognostic role of estrogen receptor alpha and estrogen receptor beta in gastric cancer. Ann Surg Oncol. 17:2503–2509. 2010. View Article : Google Scholar : PubMed/NCBI

56 

Deng H, Huang X, Fan J, Wang L, Xia Q, Yang X, Wang Z and Liu L: A variant of estrogen receptor-alpha, ER-alpha36 is expressed in human gastric cancer and is highly correlated with lymph node metastasis. Oncol Rep. 24:171–176. 2010.PubMed/NCBI

57 

Liu S, He L, Wang Z and Wen G: Expression of sex hormone receptor in gastric cancer with synchronous ovarian metastasis and its significance. Zhonghua Yi Xue Za Zhi. 94:1861–1865. 2014.(In Chinese). PubMed/NCBI

58 

Järvinen TA, Pelto-Huikko M, Holli K and Isola J: Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol. 156:29–35. 2000. View Article : Google Scholar : PubMed/NCBI

59 

Zhu X, Leav I, Leung YK, Wu M, Liu Q, Gao Y, McNeal JE and Ho SM: Dynamic regulation of estrogen receptor-beta expression by DNA methylation during prostate cancer development and metastasis. Am J Pathol. 164:2003–2012. 2004. View Article : Google Scholar : PubMed/NCBI

60 

Wang M, Pan JY, Song GR, Chen HB, An LJ and Qu SX: Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: Correlation with prothymosin alpha and clinicopathological parameters. Eur J Surg Oncol. 33:195–201. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Ryu WS, Kim JH, Jang YJ, Park SS, Um JW, Park SH, Kim SJ, Mok YJ and Kim CS: Expression of estrogen receptors in gastric cancer and their clinical significance. J Surg Oncol. 106:456–461. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Matsuyama S, Ohkura Y, Eguchi H, Kobayashi Y, Akagi K, Uchida K, Nakachi K, Gustafsson JA and Hayashi S: Estrogen receptor beta is expressed in human stomach adenocarcinoma. J Cancer Res Clin Oncol. 128:319–324. 2002. View Article : Google Scholar : PubMed/NCBI

63 

Guo JL, Xu CY, Jiang ZN, Dong MJ, Xie SD, Shen JG, Cao J and Wang LB: Estrogen receptor beta variants mRNA expressions in gastric cancer tissue samples and association with clinicopathologic parameters. Hepatogastroenterology. 57:1584–1588. 2010.PubMed/NCBI

64 

Zhou J, Teng R, Xu C, Wang Q, Guo J, Xu C, Li Z, Xie S, Shen J and Wang L: Overexpression of ERα inhibits proliferation and invasion of MKN28 gastric cancer cells by suppressing β-catenin. Oncol Rep. 30:1622–1630. 2013.PubMed/NCBI

65 

Kominea A, Konstantinopoulos PA, Kapranos N, Vandoros G, Gkermpesi M, Andricopoulos P, Artelaris S, Savva S, Varakis I, Sotiropoulou-Bonikou G and Papavassiliou AG: Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer. J Cancer Res Clin Oncol. 130:253–258. 2004. View Article : Google Scholar : PubMed/NCBI

66 

Zhang BG, Du T, Zang MD, Chang Q, Fan ZY, Li JF, Yu BQ, Su LP, Li C, Yan C, et al: Androgen receptor promotes gastric cancer cell migration and invasion via AKT-phosphorylation dependent upregulation of matrix metalloproteinase 9. Oncotarget. 5:10584–10595. 2014. View Article : Google Scholar : PubMed/NCBI

67 

Bjerregaard-Olesen C, Ghisari M, Kjeldsen LS, Wielsøe M and Bonefeld-Jørgensen EC: Estrone sulfate and dehydroepiandrosterone sulfate: Transactivation of the estrogen and androgen receptor. Steroids. 105:50–58. 2016. View Article : Google Scholar : PubMed/NCBI

68 

McKenna NJ, Lanz RB and O'Malley BW: Nuclear receptor coregulators: Cellular and molecular biology. Endocr Rev. 20:321–344. 1999. View Article : Google Scholar : PubMed/NCBI

69 

Wang W, Song XW, Bu XM, Zhang N and Zhao CH: PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors. Cell Oncol (Dordr). 39:129–137. 2016. View Article : Google Scholar : PubMed/NCBI

70 

Kershah SM, Desouki MM, Koterba KL and Rowan BG: Expression of estrogen receptor coregulators in normal and malignant human endometrium. Gynecol Oncol. 92:304–313. 2004. View Article : Google Scholar : PubMed/NCBI

71 

Zhang Z, Yamashita H, Toyama T, Sugiura H, Ando Y, Mita K, Hamaguchi M, Hara Y, Kobayashi S and Iwase H: NCOR1 mRNA is an independent prognostic factor for breast cancer. Cancer Lett. 237:123–129. 2006. View Article : Google Scholar : PubMed/NCBI

72 

Gallardo F, Padrón A, Garcia-Carbonell R, Rius C, González-Perez A, Arumí-Uria M, Iglesias M, Nonell L, Bellosillo B, Segura S, et al: Cytoplasmic accumulation of NCoR in malignant melanoma: Consequences of altered gene repression and prognostic significance. Oncotarget. 6:9284–9294. 2015. View Article : Google Scholar : PubMed/NCBI

73 

Kashima H, Horiuchi A, Uchikawa J, Miyamoto T, Suzuki A, Ashida T, Konishi I and Shiozawa T: Up-regulation of nuclear receptor corepressor (NCoR) in progestin-induced growth suppression of endometrial hyperplasia and carcinoma. Anticancer Res. 29:1023–1029. 2009.PubMed/NCBI

74 

Boorjian SA, Heemers HV, Frank I, Farmer SA, Schmidt LJ, Sebo TJ and Tindall DJ: Expression and significance of androgen receptor coactivators in urothelial carcinoma of the bladder. Endocr Relat Cancer. 16:123–137. 2009. View Article : Google Scholar : PubMed/NCBI

75 

Berns EM, van Staveren IL, Klijn JG and Foekens JA: Predictive value of SRC-1 for tamoxifen response of recurrent breast cancer. Breast Cancer Res Treat. 48:87–92. 1998. View Article : Google Scholar : PubMed/NCBI

76 

Fleming FJ, Myers E, Kelly G, Crotty TB, McDermott EW, O'Higgins NJ, Hill AD and Young LS: Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1. J Clin Pathol. 57:1069–1074. 2004. View Article : Google Scholar : PubMed/NCBI

77 

Wang S, Yuan Y, Liao L, Kuang SQ, Tien JC, O'Malley BW and Xu J: Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci USA. 106:151–156. 2009. View Article : Google Scholar : PubMed/NCBI

78 

Qin L, Chen X, Wu Y, Feng Z, He T, Wang L, Liao L and Xu J: Steroid receptor coactivator-1 upregulates integrin α5 expression to promote breast cancer cell adhesion and migration. Cancer Res. 71:1742–1751. 2011. View Article : Google Scholar : PubMed/NCBI

79 

Xu Y, Hu B, Qin L, Zhao L, Wang Q, Wang Q, Xu Y and Jiang J: SRC-1 and Twist1 expression positively correlates with a poor prognosis in human breast cancer. Int J Biol Sci. 10:396–403. 2014. View Article : Google Scholar : PubMed/NCBI

80 

Qin L, Wu YL, Toneff MJ, Li D, Liao L, Gao X, Bane FT, Tien JC, Xu Y, Feng Z, et al: NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis. Cancer Res. 74:3477–3488. 2014. View Article : Google Scholar : PubMed/NCBI

81 

Qin L, Xu Y, Xu Y, Ma G, Liao L, Wu Y, Li Y, Wang X, Wang X, Jiang J, et al: NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing HIF1α- and AP-1-mediated VEGFa transcription. Oncotarget. 6:23890–23904. 2015. View Article : Google Scholar : PubMed/NCBI

82 

Flågeng MH, Moi LL, Dixon JM, Geisler J, Lien EA, Miller WR, Lønning PE and Mellgren G: Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors. Br J Cancer. 101:1253–1260. 2009. View Article : Google Scholar : PubMed/NCBI

83 

Tai H, Kubota N and Kato S: Involvement of nuclear receptor coactivator SRC-1 in estrogen-dependent cell growth of MCF-7 cells. Biochem Biophys Res Commun. 267:311–316. 2000. View Article : Google Scholar : PubMed/NCBI

84 

Culig Z, Comuzzi B, Steiner H, Bartsch G and Hobisch A: Expression and function of androgen receptor coactivators in prostate cancer. J Steroid Biochem Mol Biol. 92:265–271. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Frycz BA, Murawa D, Borejsza‑Wysocki M, Wichtowski M, Spychała A, Marciniak R, Murawa P, Drews M and Jagodziński PP: mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer. Oncol Lett 13: 3369-3378, 2017.
APA
Frycz, B.A., Murawa, D., Borejsza‑Wysocki, M., Wichtowski, M., Spychała, A., Marciniak, R. ... Jagodziński, P.P. (2017). mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer. Oncology Letters, 13, 3369-3378. https://doi.org/10.3892/ol.2017.5881
MLA
Frycz, B. A., Murawa, D., Borejsza‑Wysocki, M., Wichtowski, M., Spychała, A., Marciniak, R., Murawa, P., Drews, M., Jagodziński, P. P."mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer". Oncology Letters 13.5 (2017): 3369-3378.
Chicago
Frycz, B. A., Murawa, D., Borejsza‑Wysocki, M., Wichtowski, M., Spychała, A., Marciniak, R., Murawa, P., Drews, M., Jagodziński, P. P."mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer". Oncology Letters 13, no. 5 (2017): 3369-3378. https://doi.org/10.3892/ol.2017.5881
Copy and paste a formatted citation
x
Spandidos Publications style
Frycz BA, Murawa D, Borejsza‑Wysocki M, Wichtowski M, Spychała A, Marciniak R, Murawa P, Drews M and Jagodziński PP: mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer. Oncol Lett 13: 3369-3378, 2017.
APA
Frycz, B.A., Murawa, D., Borejsza‑Wysocki, M., Wichtowski, M., Spychała, A., Marciniak, R. ... Jagodziński, P.P. (2017). mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer. Oncology Letters, 13, 3369-3378. https://doi.org/10.3892/ol.2017.5881
MLA
Frycz, B. A., Murawa, D., Borejsza‑Wysocki, M., Wichtowski, M., Spychała, A., Marciniak, R., Murawa, P., Drews, M., Jagodziński, P. P."mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer". Oncology Letters 13.5 (2017): 3369-3378.
Chicago
Frycz, B. A., Murawa, D., Borejsza‑Wysocki, M., Wichtowski, M., Spychała, A., Marciniak, R., Murawa, P., Drews, M., Jagodziński, P. P."mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer". Oncology Letters 13, no. 5 (2017): 3369-3378. https://doi.org/10.3892/ol.2017.5881
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team