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Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways

  • Authors:
    • Chengze Wang
    • Xin Xu
    • Hairu Jin
    • Gangli Liu
  • View Affiliations / Copyright

    Affiliations: School of Stomatology, Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3479-3486
    |
    Published online on: March 23, 2017
       https://doi.org/10.3892/ol.2017.5899
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Abstract

To investigate the effects and the possible underlying mechanisms of nicotine stimulation on tongue squamous cell carcinoma (TSCC) progression, a TSCC cell line Cal27 and 34 samples of paraffin‑embedded TSCC were examined. Immunofluorescence, western blot analysis, and TOP/FOP flash, CCK‑8, wound healing and Transwell invasion assays were used to evaluate Cal27 in response to nicotine stimulation. We also investigated expression levels of related proteins of Wnt/β‑catenin and Wnt/PCP pathways in paraffin‑embedded TSCC samples with or without a history of smoking by immunohistochemistry. Nicotine stimulation can promote proliferation, migration, and invasion of TSCC cells in vitro, downregulate E‑cadherin, and activate the Wnt/β‑catenin and Wnt/PCP pathways, which could be antagonized by the α7 nicotine acetylcholine receptor (α7 nAChR) inhibitor α‑BTX. Moreover, the expression levels of β‑catenin, Wnt5a and Ror2 were higher in TSCC patients with a history of smoking than those without a history of smoking. Our results suggest nicotine may promote tongue squamous carcinoma cells progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways and may play a significant role in the progression and metastasis of smoking‑related TSCC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Schaal C and Chellappan SP: Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers. Mol Cancer Res. 12:14–23. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Singh S, Pillai S and Chellappan S: Nicotinic acetylcholine receptor signaling in tumor growth and metastasis. J Oncol. 2011:4567432011. View Article : Google Scholar : PubMed/NCBI

4 

Schuller HM: Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat Rev Cancer. 9:195–205. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Carlisle DL, Liu X, Hopkins TM, Swick MC, Dhir R and Siegfried JM: Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. Pulm Pharmacol Ther. 20:629–641. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Shi J, Liu F, Zhang W, Liu X, Lin B and Tang X: Epigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cells. Oncol Rep. 33:2972–2980. 2015.PubMed/NCBI

7 

Zhao Y, Zhou W, Xue L, Zhang W and Zhan Q: Nicotine activates YAP1 through nAChRs mediated signaling in esophageal squamous cell cancer (ESCC). PLoS One. 9:e908362014. View Article : Google Scholar : PubMed/NCBI

8 

Yoneyama R, Aoshiba K, Furukawa K, Saito M, Kataba H, Nakamura H and Ikeda N: Nicotine enhances hepatocyte growth factor-mediated lung cancer cell migration by activating the α7 nicotine acetylcholine receptor and phosphoinositide kinase-3-dependent pathway. Oncol Lett. 11:673–677. 2016.PubMed/NCBI

9 

Zou W, Zou Y, Zhao Z, Li B and Ran P: Nicotine-induced epithelial-mesenchymal transition via Wnt/β-catenin signaling in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 304:L199–L209. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Sakurai R, Cerny LM, Torday JS and Rehan VK: Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts. Exp Lung Res. 37:144–154. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Russell MA, Jarvis M, Iyer R and Feyerabend C: Relation of nicotine yield of cigarettes to blood nicotine concentrations in smokers. Br Med J. 280:972–976. 1980. View Article : Google Scholar : PubMed/NCBI

12 

Benowitz NL: Cigarette smoking and nicotine addiction. Med Clin North Am. 76:415–437. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Liu W, Yi D, Guo J, Xiang Z, Deng L and He L: Nuciferine, extracted from Nelumbo nucifera Gaertn, inhibits tumor-promoting effect of nicotine involving Wnt/β-catenin signaling in non-small cell lung cancer. J Ethnopharmacol. 165:83–93. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Xiang T, Fei R, Wang Z, Shen Z, Qian J and Chen W: Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway. Oncol Rep. 35:205–210. 2016.PubMed/NCBI

15 

Peng C, Jia X, Xiong Y, Yin J, Li N, Deng Y, Luo K, Zhang Q, Wang C, Zhang Z, et al: The 14-3-3s/GSK3β/β-catenin/ZEB1 regulatory loop modulates chemo-sensitivity in human tongue cancer. Oncotarget. 6:20177–20189. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Yan G, Zou R, Chen Z, Fan B, Wang Z, Wang Y, Yin X, Zhang D, Tong L, Yang F, et al: Silencing RhoA inhibits migration and invasion through Wnt/β-catenin pathway and growth through cell cycle regulation in human tongue cancer. Acta Biochim Biophys Sin (Shanghai). 46:682–690. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Zheng L, Li N, Guo F, Jian XC, Jiang CH, Yin P, Min AJ and Huang L: Twist-related protein 1 enhances oral tongue squamous cell carcinoma cell invasion through β-catenin signaling. Mol Med Rep. 11:2255–2261. 2015.PubMed/NCBI

18 

Zhang A, He S, Sun X, Ding L, Bao X and Wang N: Wnt5a promotes migration of human osteosarcoma cells by triggering a phosphatidylinositol-3 kinase/Akt signals. Cancer Cell Int. 14:152014. View Article : Google Scholar : PubMed/NCBI

19 

Ma Z, Bi Q and Wang Y: Hydrogen sulfide accelerates cell cycle progression in oral squamous cell carcinoma cell lines. Oral Dis. 21:156–162. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Seidensaal K, Nollert A, Feige AH, Muller M, Fleming T, Gunkel N, Zaoui K, Grabe N, Weichert W, Weber KJ, et al: Impaired aldehyde dehydrogenase 1 subfamily member 2A-dependent retinoic acid signaling is related with a mesenchymal-like phenotype and an unfavorable prognosis of head and neck squamous cell carcinoma. Mol Cancer. 14:2042015. View Article : Google Scholar : PubMed/NCBI

21 

Chang CM, Chang PY, Tu MG, Lu CC, Kuo SC, Amagaya S, Lee CY, Jao HY, Chen MY and Yang JS: Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2. Oncol Rep. 28:1799–1807. 2012.PubMed/NCBI

22 

Psyrri A, Kotoula V, Fountzilas E, Alexopoulou Z, Bobos M, Televantou D, Karayannopoulou G, Krikelis D, Markou K, Karasmanis I, et al: Prognostic significance of the Wnt pathway in squamous cell laryngeal cancer. Oral Oncol. 50:298–305. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Maruyama K, Ochiai A, Akimoto S, Nakamura S, Baba S, Moriya Y and Hirohashi S: Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer. Oncology. 59:302–309. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Whang YM, Jo U, Sung JS, Ju HJ, Kim HK, Park KH, Lee JW, Koh IS and Kim YH: Wnt5a is associated with cigarette smoke-related lung carcinogenesis via protein kinase C. PLoS One. 8:e530122013. View Article : Google Scholar : PubMed/NCBI

25 

Liu G, Sengupta PK, Jamal B, Yang HY, Bouchie MP, Lindner V, Varelas X and Kukuruzinska MA: N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration. J Biol Chem. 288:20217–20227. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Schwam ZG and Judson BL: Improved prognosis for patients with oral cavity squamous cell carcinoma: Analysis of the National Cancer Database 1998–2006. Oral Oncol. 52:45–51. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Yu C and Chang Y: Enhancement of cancer stem-like and epithelial-mesenchymal transdifferentiation property in oral epithelial cells with long-term nicotine exposure: Reversal by targeting SNAIL. Toxicol Appl Pharmacol. 266:459–469. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Jiao J, Zhao X, Liang Y, Tang D and Pan C: FGF1-FGFR1 axis promotes tongue squamous cell carcinoma (TSCC) metastasis through epithelial-mesenchymal transition (EMT). Biochem Biophys Res Commun. 466:327–332. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Pasquier J, Abu-Kaoud N, Al Thani H and Rafii A: Epithelial to mesenchymal transition in a clinical perspective. J Oncol. 2015:7921822015. View Article : Google Scholar : PubMed/NCBI

30 

Zhu R, Jiang XY, Song XL, Zhang W, Chen S and Liu LK: Expression of E-cadherin and beta-catenin in oral squamous cell carcinomas of tongue: Correlation with the clinicopathologic features and patient prognosis. Zhonghua Kou Qiang Yi Xue Za Zhi. 45:295–298. 2010.(In Chinese). PubMed/NCBI

31 

Chow V, Yuen AP, Lam KY, Tsao GS, Ho WK and Wei WI: A comparative study of the clinicopathological significance of E-cadherin and catenins (alpha, beta, gamma) expression in the surgical management of oral tongue carcinoma. J Cancer Res Clin Oncol. 127:59–63. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Chaw SY, Majeed Abdul A, Dalley AJ, Chan A, Stein S and Farah CS: Epithelial to mesenchymal transition (EMT) biomarkers-E-cadherin, beta-catenin, APC and Vimentin-in oral squamous cell carcinogenesis and transformation. Oral Oncol. 48:997–1006. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Walker A, Frei R and Lawson KR: The cytoplasmic domain of N-cadherin modulates MMP9 induction in oral squamous carcinoma cells. Int J Oncol. 45:1699–1706. 2014.PubMed/NCBI

34 

Jiang Q, Wei MD, Wang KW, Lan YX, Zhu N and Wang Y: Nicotine contributes to the neural stem cells fate against toxicity of microglial-derived factors induced by Aβ via the Wnt/β-catenin pathway. Int J Neurosci. 126:257–268. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Gong WY, Wu JF, Liu BJ, Zhang HY, Cao YX, Sun J, Lv YB, Wu X and Dong JC: Flavonoid components in Scutellaria baicalensis inhibit nicotine-induced proliferation, metastasis and lung cancer-associated inflammation in vitro. Int J Oncol. 44:1561–1570. 2014.PubMed/NCBI

36 

Shojima K, Sato A, Hanaki H, Tsujimoto I, Nakamura M, Hattori K, Sato Y, Dohi K, Hirata M, Yamamoto H and Kikuchi A: Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively. Sci Rep. 5:80422015. View Article : Google Scholar : PubMed/NCBI

37 

Kobayashi M, Shibuya Y, Takeuchi J, Murata M, Suzuki H, Yokoo S, Umeda M, Minami Y and Komori T: Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 107:398–406. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang C, Xu X, Jin H and Liu G: Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways . Oncol Lett 13: 3479-3486, 2017.
APA
Wang, C., Xu, X., Jin, H., & Liu, G. (2017). Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways . Oncology Letters, 13, 3479-3486. https://doi.org/10.3892/ol.2017.5899
MLA
Wang, C., Xu, X., Jin, H., Liu, G."Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways ". Oncology Letters 13.5 (2017): 3479-3486.
Chicago
Wang, C., Xu, X., Jin, H., Liu, G."Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways ". Oncology Letters 13, no. 5 (2017): 3479-3486. https://doi.org/10.3892/ol.2017.5899
Copy and paste a formatted citation
x
Spandidos Publications style
Wang C, Xu X, Jin H and Liu G: Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways . Oncol Lett 13: 3479-3486, 2017.
APA
Wang, C., Xu, X., Jin, H., & Liu, G. (2017). Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways . Oncology Letters, 13, 3479-3486. https://doi.org/10.3892/ol.2017.5899
MLA
Wang, C., Xu, X., Jin, H., Liu, G."Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways ". Oncology Letters 13.5 (2017): 3479-3486.
Chicago
Wang, C., Xu, X., Jin, H., Liu, G."Nicotine may promote tongue squamous cell carcinoma progression by activating the Wnt/β‑catenin and Wnt/PCP signaling pathways ". Oncology Letters 13, no. 5 (2017): 3479-3486. https://doi.org/10.3892/ol.2017.5899
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