MicroRNA‑592 targets IGF‑1R to suppress cellular proliferation, migration and invasion in hepatocellular carcinoma

Wang,Wenyao; Zhang,Hongfei; Tang,Mao; Liu,Longlong; Zhou,Zhengfang; Zhang,Shaojun; Wang,Lichao

doi:10.3892/ol.2017.5902

MicroRNA‑592 targets IGF‑1R to suppress cellular proliferation, migration and invasion in hepatocellular carcinoma

Authors:
- Wenyao Wang
- Hongfei Zhang
- Mao Tang
- Longlong Liu
- Zhengfang Zhou
- Shaojun Zhang
- Lichao Wang
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Affiliations: Department of General Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China
Published online on: March 24, 2017 https://doi.org/10.3892/ol.2017.5902
Pages: 3522-3528
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

MicroRNAs (miRs) can function as tumor suppressors or oncogenes in different types of human malignancy, and may provide an effective therapy for cancer. The expression and functions of miR‑592 have previously been studied in relation to cancer. However, the expression and potential functions of miR‑592 in hepatocellular carcinoma (HCC) are still unknown. Using quantitative polymerase chain reaction, MTT assays, cellular migration and invasion assays, bioinformatics software, western blot analysis and dual‑luciferase report assays, the present study explored the expression and roles of miR‑592 in HCC. It was identified that miR‑592 was significantly downregulated in HCC tissues and cell lines. The statistical analysis revealed that low expression of miR‑592 was evidently associated with tumor node metastasis stage and lymph node metastasis. Additionally, the present study provided the first evidence that miR‑592 was likely to directly target the insulin‑like growth factor 1 receptor in vitro. The present results indicated that miR‑592 could be investigated as an efficacious therapeutic target for HCC in the future.

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