miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3

  • Authors:
    • Ruilin Chen
    • Yongqing Zhang
    • Chengcheng Zhang
    • Hua Wu
    • Shumei Yang
  • View Affiliations

  • Published online on: March 24, 2017     https://doi.org/10.3892/ol.2017.5904
  • Pages: 3905-3911
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer. The results of the present study demonstrate that high expression of microRNA (miR)‑137 and low expression of steroid receptor coactivator‑3 (SRC3) had a significant negative correlation in 40 NSCLC tissue samples. In addition, cell colony formation and proliferation was significantly reduced in miR‑137‑transfected A549 and NCI‑H838 cells compared with scramble‑transfected NSCLC cell lines. miR‑137 was identified to induce G1/S cell cycle arrest and dysregulate the mRNA expression of cell cycle‑associated proteins (proliferating cell nuclear antigen, cyclin E, cyclin A1, cyclin A2 and p21) in NSCLC cells. Notably, miR‑137 could significantly suppress SRC3 3' untranslated region (UTR) luciferase‑reporter activity, an effect that was not detectable when the putative 3'‑UTR target‑site was mutated, further clarifying the molecular mechanisms underlying the role of miR‑137 in NSCLC. In conclusion, the results of the present study suggest that miR‑137 suppresses NSCLC cell proliferation by partially targeting SRC3.
View Figures
View References

Related Articles

Journal Cover

May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen R, Zhang Y, Zhang C, Wu H and Yang S: miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3. Oncol Lett 13: 3905-3911, 2017
APA
Chen, R., Zhang, Y., Zhang, C., Wu, H., & Yang, S. (2017). miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3. Oncology Letters, 13, 3905-3911. https://doi.org/10.3892/ol.2017.5904
MLA
Chen, R., Zhang, Y., Zhang, C., Wu, H., Yang, S."miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3". Oncology Letters 13.5 (2017): 3905-3911.
Chicago
Chen, R., Zhang, Y., Zhang, C., Wu, H., Yang, S."miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3". Oncology Letters 13, no. 5 (2017): 3905-3911. https://doi.org/10.3892/ol.2017.5904