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Article

miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3

  • Authors:
    • Ruilin Chen
    • Yongqing Zhang
    • Chengcheng Zhang
    • Hua Wu
    • Shumei Yang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi 710068, P.R. China
  • Pages: 3905-3911
    |
    Published online on: March 24, 2017
       https://doi.org/10.3892/ol.2017.5904
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Abstract

Non‑small cell lung cancer (NSCLC) is the most common type of lung cancer. The results of the present study demonstrate that high expression of microRNA (miR)‑137 and low expression of steroid receptor coactivator‑3 (SRC3) had a significant negative correlation in 40 NSCLC tissue samples. In addition, cell colony formation and proliferation was significantly reduced in miR‑137‑transfected A549 and NCI‑H838 cells compared with scramble‑transfected NSCLC cell lines. miR‑137 was identified to induce G1/S cell cycle arrest and dysregulate the mRNA expression of cell cycle‑associated proteins (proliferating cell nuclear antigen, cyclin E, cyclin A1, cyclin A2 and p21) in NSCLC cells. Notably, miR‑137 could significantly suppress SRC3 3' untranslated region (UTR) luciferase‑reporter activity, an effect that was not detectable when the putative 3'‑UTR target‑site was mutated, further clarifying the molecular mechanisms underlying the role of miR‑137 in NSCLC. In conclusion, the results of the present study suggest that miR‑137 suppresses NSCLC cell proliferation by partially targeting SRC3.
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1 

Jemal A, Center MM, DeSantis C and Ward EM: Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 19:1893–1907. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Yu JL, Simmons C, Victor JC, Han D, Hogeveen S, Leighl N and Verma S: Impact of new chemotherapeutic and targeted agents on survival in stage IV non-small cell lung cancer. Oncologist. 16:1307–1315. 2011. View Article : Google Scholar : PubMed/NCBI

4 

He L and Hannon GJ: MicroRNAs: Small RNAs with a big role in gene regulation. Nat Rev Genet. 5:522–531. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Du L, Borkowski R, Zhao Z, Ma X, Yu X, Xie XJ and Pertsemlidis A: A high-throughput screen identifies miRNA inhibitors regulating lung cancer cell survival and response to paclitaxel. RNA Biol. 10:1700–1713. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Guo HL, Ingolia NT, Weissman JS and Bartel DP: Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature. 466:835–840. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Chen QJ, Chen XB, Zhang MZ, Fan QX, Luo SX and Cao XG: miR-137 is frequently down-regulated in gastric cancer and is a negative regulator of Cdc42. Dig Dis Sci. 56:2009–2016. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Zhao YY, Li YP, Lou GY, Zhao L, Xu Z, Zhang Y and He F: MiR-137 targets estrogen-related receptor alpha and impairs the proliferative and migratory capacity of breast cancer cells. PLoS One. 7:e391022012. View Article : Google Scholar : PubMed/NCBI

9 

Bi Y, Han Y, Bi H, Gao F and Wang X: miR-137 impairs the proliferative and migratory capacity of human non-small cell lung cancer cells by targeting paxillin. Hum Cell. 27:95–102. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Zhu X, Li Y, Shen H, Li H, Long L, Hui L and Xu W: miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6. FEBS Lett. 587:73–81. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Dacic S, Kelly L, Shuai Y and Nikiforova MN: miRNA expression profiling of lung adenocarcinomas: Correlation with mutational status. Mod pathol. 23:1577–1582. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Ciafrè SA, Galardi S, Mangiola A, Ferracin M, Liu CG, Sabatino G, Negrini M, Maira G, Croce CM and Farace MG: Extensive modulation of a set of microRNAs in primary glioblastoma. Biochem Biophys Res Commun. 334:1351–1358. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Bandrés E, Cubedo E, Agirre X, Malumbres R, Zárate R, Ramirez N, Abajo A, Navarro A, Moreno I, Monzó M and García-Foncillas J: Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer. 5:292006. View Article : Google Scholar : PubMed/NCBI

14 

Svoboda M, Izakovicova Holla L, Sefr R, Vrtkova I, Kocakova I, Tichy B and Dvorak J: Micro-RNAs miR125b and miR137 are frequently upregulated in response to capecitabine chemoradiotherapy of rectal cancer. Int J Oncol. 33:541–547. 2008.PubMed/NCBI

15 

Zhang B, Liu T, Wu T, Wang Z, Rao Z and Gao J: microRNA-137 functions as a tumor suppressor in human non-small cell lung cancer by targeting SLC22A18. Int J Biol Macromol. 74:111–118. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Li P, Ma L, Zhang Y, Ji F and Jin F: MicroRNA-137 down-regulates KIT and inhibits small cell lung cancer cell proliferation. Biomed Pharmacother. 68:7–12. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Shi H, Ji Y, Zhang D, Liu Y and Fang P: MiR-135a inhibits migration and invasion and regulates EMT-related marker genes by targeting KLF8 in lung cancer cells. Biochem Biophys Res Commun. 465:125–130. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zhen Q, Liu J, Gao L, Liu J, Wang R, Chu W, Zhang Y, Tan G, Zhao X and Lv B: MicroRNA-200a targets EGFR and c-Met to inhibit migration, invasion and gefitinib resistance in non-small cell lung cancer. Cytogenet Genome Res. 146:1–8. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Hossain A, Kuo MT and Saunders GF: Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol. 26:8191–8201. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Xu J and OMalley BW: Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function. Rev Endocr Metab Disord. 3:185–192. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM and Meltzer PS: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science. 277:965–968. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Waters CE, Stevens A, White A and Ray DW: Analysis of co-factor function in a glucocorticoid-resistant small cell carcinoma cell line. J Endocrinol. 183:375–383. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Henke RT, Haddad BR, Kim SE, Rone JD, Mani A, Jessup JM, Wellstein A, Maitra A and Riegel AT: Overexpression of the nuclear receptor coactivator AIB1, (SRC-3) during progression of pancreatic adenocarcinoma. Clin Cancer Res. 10:6134–6142. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Suen CS, Berrodin TJ, Mastroeni R, Cheskis BJ, Lyttle CR and Frail DE: A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity. J Biol Chem. 273:27645–27653. 1998. View Article : Google Scholar : PubMed/NCBI

25 

Wang H, Zhang D, Wu W, Zhang J, Guo D, Wang Q, Jing T, Xu C, Bian X and Yang K: Overexpression and gender-specific differences of SRC-3 (SRC-3/AIB1) immunoreactivity in human non-small cell lung cancer: an in vivo study. J Histochem Cytochem. 58:1121–1127. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Jiang HL, Yu H, Ma X, Xu D, Lin GF, Ma DY and Jin JZ: MicroRNA-195 regulates steroid receptor coactivator-3 protein expression in hepatocellular carcinoma cells. Tumour Biol. 35:6955–6960. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, et al: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. Bmc Med. 6:142008. View Article : Google Scholar : PubMed/NCBI

28 

Balaguer F, Link A, Lozano JJ, Cuatrecasas M, Nagasaka T, Boland CR and Goel A: Epigenetic Silencing of miR-137 is an early event in colorectal carcinogenesis. Cancer Res. 70:6609–6618. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Huang T, Jiang M, Kong XY and Cai YD: Dysfunctions associated with methylation, microRNA expression and gene expression in lung cancer. PLoS One. 7:e434412012. View Article : Google Scholar : PubMed/NCBI

30 

Shiomi N, Mori M, Tsuji H, Imai T, Inoue H, Tateishi S, Yamaizumi M and Shiomi T: Human RAD18 is involved in S phase-specific single-strand break repair without PCNA monoubiquitination. Nucleic Acids Res. 35:e92007. View Article : Google Scholar : PubMed/NCBI

31 

Deng J, He M, Chen L, Chen C, Zheng J and Cai Z: The loss of miR-26a-mediated post-transcriptional regulation of cyclin E2 in pancreatic cancer cell proliferation and decreased patient survival. PLoS One. 8:e764502013. View Article : Google Scholar : PubMed/NCBI

32 

Cheung TH and Rando TA: Molecular regulation of stem cell quiescence. Nat Rev Mol Cell Bio. 14:329–340. 2013. View Article : Google Scholar

33 

Levkau B, Koyama H, Raines EW, Clurman BE, Herren B, Orth K, Roberts JM and Ross R: Cleavage of p21 (Cip1/Waf1) and p27 (Kip1) mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade. Mol Cell. 1:553–563. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Jun GJ, Zhong GG and Ming ZS: miR-218 inhibits the proliferation of glioma U87 cells through the inactivation of the CDK6/cyclin D1/p21(Cip1/Waf1) pathway. Oncol Lett. 9:2743–2749. 2015.PubMed/NCBI

35 

Deng Y, Deng H, Bi F, Liu J, Bemis LT, Norris D, Wang XJ and Zhang Q: MicroRNA-137 targets carboxyl-terminal binding protein 1 in melanoma cell lines. Int J Biol Sci. 7:133–137. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen R, Zhang Y, Zhang C, Wu H and Yang S: miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3. Oncol Lett 13: 3905-3911, 2017.
APA
Chen, R., Zhang, Y., Zhang, C., Wu, H., & Yang, S. (2017). miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3. Oncology Letters, 13, 3905-3911. https://doi.org/10.3892/ol.2017.5904
MLA
Chen, R., Zhang, Y., Zhang, C., Wu, H., Yang, S."miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3". Oncology Letters 13.5 (2017): 3905-3911.
Chicago
Chen, R., Zhang, Y., Zhang, C., Wu, H., Yang, S."miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3". Oncology Letters 13, no. 5 (2017): 3905-3911. https://doi.org/10.3892/ol.2017.5904
Copy and paste a formatted citation
x
Spandidos Publications style
Chen R, Zhang Y, Zhang C, Wu H and Yang S: miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3. Oncol Lett 13: 3905-3911, 2017.
APA
Chen, R., Zhang, Y., Zhang, C., Wu, H., & Yang, S. (2017). miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3. Oncology Letters, 13, 3905-3911. https://doi.org/10.3892/ol.2017.5904
MLA
Chen, R., Zhang, Y., Zhang, C., Wu, H., Yang, S."miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3". Oncology Letters 13.5 (2017): 3905-3911.
Chicago
Chen, R., Zhang, Y., Zhang, C., Wu, H., Yang, S."miR‑137 inhibits the proliferation of human non‑small cell lung cancer cells by targeting SRC3". Oncology Letters 13, no. 5 (2017): 3905-3911. https://doi.org/10.3892/ol.2017.5904
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