Open Access

Evaluation of microRNA‑205 expression as a potential triage marker for patients with low‑grade squamous intraepithelial lesions

  • Authors:
    • Hong Xie
    • Ingrid Norman
    • Anders Hjerpe
    • Tomislav Vladic
    • Catharina Larsson
    • Weng‑Onn Lui
    • Ellinor Östensson
    • Sonia Andersson
  • View Affiliations

  • Published online on: March 24, 2017     https://doi.org/10.3892/ol.2017.5909
  • Pages: 3586-3598
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

High-risk human papillomavirus (HPV) testing is a recommended triage approach for females with atypical squamous cells of undetermined significance (ASCUS), but due to its poor specificity this approach is not recommended for patients with low‑grade squamous intraepithelial lesions (LSIL). The objective of the current study was to determine microRNA (miR)‑205 expression levels in liquid‑based cytology (LBC) samples, and evaluate their ability to predict cervical intraepithelial neoplasia grade 2/3 or worse (CIN2/3+) in females with minor cytological abnormalities. LBC samples were obtained from patients attending the Swedish Cervical Cancer Screening Program. The Mann‑Whitney U test, one‑way analysis of variance, Kruskal‑Wallis test, Spearman rank order correlation analysis, and Pearson's χ2 test were used to assess the results. Accuracy analyses indicated that high miR‑205 expression had a significantly higher specificity to high‑risk HPV testing, and a sensitivity similar to that of high‑risk HPV testing to predict CIN2+ and CIN3+ in women with LSIL, but not those with high‑grade squamous intraepithelial lesions. Although further research is required for females with LSIL, miR‑205 expression in LBC samples may be a novel triage marker for, or a beneficial supplement to high‑risk‑HPV testing in these patients.
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May-2017
Volume 13 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xie H, Norman I, Hjerpe A, Vladic T, Larsson C, Lui WO, Östensson E and Andersson S: Evaluation of microRNA‑205 expression as a potential triage marker for patients with low‑grade squamous intraepithelial lesions. Oncol Lett 13: 3586-3598, 2017
APA
Xie, H., Norman, I., Hjerpe, A., Vladic, T., Larsson, C., Lui, W. ... Andersson, S. (2017). Evaluation of microRNA‑205 expression as a potential triage marker for patients with low‑grade squamous intraepithelial lesions. Oncology Letters, 13, 3586-3598. https://doi.org/10.3892/ol.2017.5909
MLA
Xie, H., Norman, I., Hjerpe, A., Vladic, T., Larsson, C., Lui, W., Östensson, E., Andersson, S."Evaluation of microRNA‑205 expression as a potential triage marker for patients with low‑grade squamous intraepithelial lesions". Oncology Letters 13.5 (2017): 3586-3598.
Chicago
Xie, H., Norman, I., Hjerpe, A., Vladic, T., Larsson, C., Lui, W., Östensson, E., Andersson, S."Evaluation of microRNA‑205 expression as a potential triage marker for patients with low‑grade squamous intraepithelial lesions". Oncology Letters 13, no. 5 (2017): 3586-3598. https://doi.org/10.3892/ol.2017.5909