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Article Open Access

Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells

  • Authors:
    • Qian Zhang
    • Qiong Luo
    • Xueyu Yuan
    • Li Chai
    • Dan Li
    • Jianjun Liu
    • Zhongwei Lv
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Department of Intensive Care Unit, Central Hospital of Zhabei District, Shanghai 200000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3445-3450
    |
    Published online on: March 29, 2017
       https://doi.org/10.3892/ol.2017.5947
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Abstract

Epidemiological data has demonstrated that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 µm (PM2.5) is associated with cancer incidence. However, the precise mechanisms underlying PM2.5‑mediated hepatocellular carcinoma cancer (HCC) migration and invasion remain unclear. The aim of the present study was to explore the response of the HCC cell lines HepG2 and HuH-7 to PM2.5 exposure. The results revealed that PM2.5 treatment promoted the migration and invasion of HCC cells, in addition to increasing protein levels of matrix metalloproteinase (MMP)‑13. Additionally, PM2.5 induced intracellular reactive oxygen species formation in HCC cells. Further investigation revealed that phosphorylation of RAC‑alpha serine/threonine‑protein kinase (AKT) increased in response to PM2.5 exposure in HCC cells, and the AKT antagonist LY294002 reduced PM2.5‑induced migration, invasion and MMP‑13 expression. In addition, the data from the present study demonstrated that high concentrations of PM2.5 decreased the proliferation of normal HL7702 hepatocyte cells and promoted apoptosis. These results indicate that the activation of AKT by PM2.5 results in MMP‑13 overexpression, and stimulates HCC cell migration and invasion. In conclusion, the results from the present study demonstrate that PM2.5 promotes HCC development and elucidate a potential underlying molecular mechanism for this effect.
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1 

Hou X, Strickland MJ and Liao KJ: Contributions of regional air pollutant emissions to ozone and fine particulate matter-related mortalities in eastern U.S. urban areas. Environ Res. 137:475–484. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Eze IC, Schaffner E, Fischer E, Schikowski T, Adam M, Imboden M, Tsai M, Carballo D, von Eckardstein A, Künzli N, et al: Long-term air pollution exposure and diabetes in a population-based Swiss cohort. Environ Int. 70:95–105. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Chow JC: Health effects of fine particulate air pollution: Lines that connect. J Air Waste Manag Assoc. 56:707–708. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, Guha N, Baan R, Mattock H and Straif K: International Agency for Research on Cancer Monograph Working Group IARC: The carcinogenicity of outdoor air pollution. Lancet Oncol. 14:1262–1263. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Loomis D, Huang W and Chen G: The International Agency for Research on Cancer (IARC) evaluation of the carcinogenicity of outdoor air pollution: Focus on China. Chin J Cancer. 33:189–196. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Boström CE, Gerde P, Hanberg A, Jernström B, Johansson C, Kyrklund T, Rannug A, Törnqvist M, Victorin K and Westerholm R: Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ Health Perspect. 110:(Suppl 3). S451–S488. 2002. View Article : Google Scholar

7 

Xia Z, Duan X, Tao S, Qiu W, Liu D, Wang Y, Wei S, Wang B, Jiang Q, Lu B, et al: Pollution level, inhalation exposure and lung cancer risk of ambient atmospheric polycyclic aromatic hydrocarbons (PAHs) in Taiyuan, China. Environ Pollut. 173:150–156. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Tang D, Sun B, Yu H, Yang Z and Zhu L: Tumor-suppressing effect of miR-4458 on human hepatocellular carcinoma. Cell Physiol Biochem. 35:1797–1807. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Gores GJ: Decade in review-hepatocellular carcinoma: HCC-subtypes, stratification and sorafenib. Nat Rev Gastroenterol Hepatol. 11:645–647. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Zhang X, Ng HL, Lu A, Lin C, Zhou L, Lin G, Zhang Y, Yang Z and Zhang H: Drug delivery system targeting advanced hepatocellular carcinoma: Current and future. Nanomedicine. 12:853–869. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Shu Y, Zhu L, Yuan F, Kong X, Huang T and Cai YD: Analysis of the relationship between PM2.5 and lung cancer based on protein-protein interactions. Comb Chem High Throughput Screen. 19:100–108. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Pan WC, Wu CD, Chen MJ, Huang YT, Chen CJ, Su HJ and Yang HI: Fine Particle Pollution, Alanine Transaminase, and Liver Cancer: A Taiwanese Prospective Cohort Study (REVEAL-HBV). J Natl Cancer Inst. 108:pii: djv341. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Deng G, Hu C, Zhu L, Huang F, Huang W, Xu H and Nie W: Downregulation of ROS-FIG inhibits cell proliferation, colony formation, cell cycle progression, migration and invasion, while inducing apoptosis in intrahepatic cholangiocarcinoma cells. Int J Mol Med. 34:661–668. 2014.PubMed/NCBI

14 

Shao J, Xue J, Dai Y, Liu H, Chen N, Jia L and Huang J: Inhibition of human hepatocellular carcinoma HepG2 by phthalocyanine photosensitiser PHOTOCYANINE: ROS production, apoptosis, cell cycle arrest. Eur J Cancer. 48:2086–2096. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Hou YQ, Yao Y, Bao YL, Song ZB, Yang C, Gao XL, Zhang WJ, Sun LG, Yu CL, Huang YX, et al: Juglanthraquinone C Induces Intracellular ROS Increase and Apoptosis by Activating the Akt/Foxo Signal Pathway in HCC Cells. Oxid Med Cell Longev. 2016:49416232016. View Article : Google Scholar : PubMed/NCBI

16 

Adhikary A, Mohanty S, Lahiry L, Hossain DM, Chakraborty S and Das T: Theaflavins retard human breast cancer cell migration by inhibiting NF-kappaB via p53-ROS cross-talk. FEBS Lett. 584:7–14. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Zhou W, Tian D, He J, Wang Y, Zhang L, Cui L, Jia L, Zhang L, Li L, Shu Y, et al: Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation. Oncotarget. 7:20691–21703. 2016.PubMed/NCBI

18 

Torres-Ramos YD, Montoya-Estrada A, Guzman-Grenfell AM, Mancilla-Ramirez J, Cardenas-Gonzalez B, Blanco-Jimenez S, Sepulveda-Sanchez JD, Ramirez-Venegas A and Hicks JJ: Urban PM2.5 induces ROS generation and RBC damage in COPD patients. Front Biosci (Elite Ed). 3:808–817. 2011.PubMed/NCBI

19 

Verma V, Fang T, Xu L, Peltier RE, Russell AG, Ng NL and Weber RJ: Organic aerosols associated with the generation of reactive oxygen species (ROS) by water-soluble PM2.5. Environ Sci Technol. 49:4646–4656. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Wang YH, Sui XM, Sui YN, Zhu QW, Yan K, Wang LS, Wang F and Zhou JH: BRD4 induces cell migration and invasion in HCC cells through MMP-2 and MMP-9 activation mediated by the Sonic hedgehog signaling pathway. Oncol Lett. 10:2227–2232. 2015.PubMed/NCBI

21 

Yang Z, Zhang Y and Wang L: A feedback inhibition between miRNA-127 and TGFβ/c-Jun cascade in HCC cell migration via MMP13. PLoS One. 8:e652562013. View Article : Google Scholar : PubMed/NCBI

22 

Kotepui M, Thawornkuno C, Chavalitshewinkoon-Petmitr P, Punyarit P and Petmitr S: Quantitative real-time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA expression in breast cancer. Asian Pac J Cancer Prev. 13:5879–5882. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Shah M, Huang D, Blick T, Connor A, Reiter LA, Hardink JR, Lynch CC, Waltham M and Thompson EW: An MMP13-selective inhibitor delays primary tumor growth and the onset of tumor-associated osteolytic lesions in experimental models of breast cancer. PLoS One. 7:e296152012. View Article : Google Scholar : PubMed/NCBI

24 

Wang Y, Huang X, Han J, Zheng W and Ma W: Extract of Perilla frutescens inhibits tumor proliferation of HCC via PI3K/AKT signal pathway. Afr J Tradit Complement Altern Med. 10:251–257. 2013.PubMed/NCBI

25 

Sui Y, Zheng X and Zhao D: Rab31 promoted hepatocellular carcinoma (HCC) progression via inhibition of cell apoptosis induced by PI3K/AKT/Bcl-2/BAX pathway. Tumour Biol. 36:8661–8670. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Li W, Jiang G, Zhou J, Wang H, Gong Z, Zhang Z, Min K, Zhu H and Tan Y: Down-regulation of miR-140 induces EMT and promotes invasion by targeting Slug in esophageal cancer. Cell Physiol Biochem. 34:1466–1476. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Cao J, Qin G, Shi R, Bai F, Yang G, Zhang M and Lv J: Overproduction of reactive oxygen species and activation of MAPKs are involved in apoptosis induced by PM2.5 in rat cardiac H9c2 cells. J Appl Toxicol. 36:609–617. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Jin D, Tao J, Li D, Wang Y, Li L, Hu Z, Zhou Z, Chang X, Qu C and Zhang H: Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion. Oncotarget. 6:33523–33533. 2015.PubMed/NCBI

29 

Ji Y, Wang Z, Li Z, Zhang A, Jin Y, Chen H and Le X: Angiotensin II Enhances Proliferation and Inflammation through AT1/PKC/NF-κB Signaling Pathway in Hepatocellular Carcinoma Cells. Cell Physiol Biochem. 39:13–32. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Tong GQ, Zhang ZH, Zhao Y, Liu JJ and Han JB: Traffic-related PM2.5 induces cytosolic [Ca2+] increase regulated by Orai1, alters the CaN-NFAT signaling pathway, and affects IL-2 and TNF-α cytoplasmic levels in Jurkat T-cells. Arch Environ Contam Toxicol. 68:31–37. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Xu L, Sun K, Xia M, Li X and Lu Y: MMP13 regulates aggressiveness of pediatric multiple myeloma through VEGF-C. Cell Physiol Biochem. 36:509–516. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Luo Q, Yuan X, Chai L, Li D, Liu J and Lv Z: Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells. Oncol Lett 13: 3445-3450, 2017.
APA
Zhang, Q., Luo, Q., Yuan, X., Chai, L., Li, D., Liu, J., & Lv, Z. (2017). Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells. Oncology Letters, 13, 3445-3450. https://doi.org/10.3892/ol.2017.5947
MLA
Zhang, Q., Luo, Q., Yuan, X., Chai, L., Li, D., Liu, J., Lv, Z."Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells". Oncology Letters 13.5 (2017): 3445-3450.
Chicago
Zhang, Q., Luo, Q., Yuan, X., Chai, L., Li, D., Liu, J., Lv, Z."Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells". Oncology Letters 13, no. 5 (2017): 3445-3450. https://doi.org/10.3892/ol.2017.5947
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Luo Q, Yuan X, Chai L, Li D, Liu J and Lv Z: Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells. Oncol Lett 13: 3445-3450, 2017.
APA
Zhang, Q., Luo, Q., Yuan, X., Chai, L., Li, D., Liu, J., & Lv, Z. (2017). Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells. Oncology Letters, 13, 3445-3450. https://doi.org/10.3892/ol.2017.5947
MLA
Zhang, Q., Luo, Q., Yuan, X., Chai, L., Li, D., Liu, J., Lv, Z."Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells". Oncology Letters 13.5 (2017): 3445-3450.
Chicago
Zhang, Q., Luo, Q., Yuan, X., Chai, L., Li, D., Liu, J., Lv, Z."Atmospheric particulate matter2.5 promotes the migration and invasion of hepatocellular carcinoma cells". Oncology Letters 13, no. 5 (2017): 3445-3450. https://doi.org/10.3892/ol.2017.5947
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