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Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer

  • Authors:
    • Felicitas Mungenast
    • Stefanie Aust
    • Ignace Vergote
    • Adriaan Vanderstichele
    • Jalid Sehouli
    • Elena Braicu
    • Sven Mahner
    • Dan Cacsire Castillo‑Tong
    • Robert Zeillinger
    • Theresia Thalhammer
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, A‑1090 Vienna, Austria, Department of Gynaecology and Gynaecological Oncology, Comprehensive Cancer Center, Medical University of Vienna, A‑1090 Vienna, Austria, Division of Gynaecological Oncology, Department of Obstetrics and Gynaecology, Catholic University of Leuven, University Hospital, B‑3000 Leuven, Belgium, Department of Gynaecology, European Competence Center for Ovarian Cancer, Virchow Clinic Campus, Medical University of Berlin, D‑13353 Berlin, Germany, Department of Gynaecology and Obstetrics, University of Munich, D‑80539 Munich, Germany, Translational Gynaecology Group, Department of Obstetrics and Gynaecology, Comprehensive Cancer Center, Medical University of Vienna, A‑1090 Vienna, Austria, Molecular Oncology Group, Department of Obstetrics and Gynaecology, Comprehensive Cancer Center, Medical University of Vienna, A‑1090 Vienna, Austria
    Copyright: © Mungenast et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4047-4054
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    Published online on: April 3, 2017
       https://doi.org/10.3892/ol.2017.5969
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Abstract

17β-estradiol (E2) can contribute to the progression of epithelial ovarian cancer (EOC). Although the majority of patients with EOC are postmenopausal woman, when de novo estrogen production in the ovary has ceased, ovarian cancer cells remain exposed to estrogens synthesized locally in the cancer cells from inactive sulfonated steroid hormone precursors-such as estrone sulfate taken up from the circulation via the sulfatase pathway. An abundance of the estrogen-modifying enzymes, including estrogen‑activating steroid sulfatase (STS) and estrogen‑inactivating estrogen-sulfotransferase (SULT1E1), is important for providing active estrogen to EOC cells. Therefore, the present study determined the levels of SULT1E1, STS and estrogen receptor α (ERα) protein in paraffin‑embedded specimens from 206 patients with Federation of Gynecology and Obstetrics stage II‑IV EOC treated with debulking surgery and standard platinum‑based adjuvant chemotherapy. The levels of STS, SULT1E1 and ERα were assessed by automated quantitative microscopy-based image analysis subsequent to immunohistochemical staining. Significantly higher SULT1E1 levels were observed in better differentiated EOC tumors compared to grade 3 EOC tumors (P=0.001). STS and SULT1E1 levels were positively associated with ERα abundance (P<0.001 and P=0.001, respectively). In advanced stage high‑grade serous EOC (HGSOC; n=132), the most frequent and lethal type of ovarian cancer, SULT1E1 expression was significantly associated with a better overall survival rate (hazard ratio 0.66, 95% confidence interval, 0.45‑0.94; P=0.005). These results highlight the importance of SULT1E1‑mediated estrogen inactivation in EOC, particularly HGSOC. Therefore, targeting the sulfatase pathway is a potential endocrine therapeutic intervention for certain patients with estrogen‑responsive EOC.
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View References

1 

American Cancer Society, American Cancer Society, . 2016 Ovarian epithelial, fallopian tube and primary peritoneal cancer treatment (PDQ®). https://www.cancer.gov/types/ovarian/hp/ovarian-epithelial-treatment-pdqJanuary 17–2017.

2 

Kessler M, Fotopoulou C and Meyer T: The molecular fingerprint of high grade serous ovarian cancer reflects its fallopian tube origin. Int J Mol Sci. 14:6571–6596. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Brown J and Frumovitz M: Mucinous tumors of the ovary: Current thoughts on diagnosis and management. Curr Oncol Rep. 16:3892014. View Article : Google Scholar : PubMed/NCBI

4 

Sapiezynski J, Taratula O, Rodriguez-Rodriguez L and Minko T: Precision targeted therapy of ovarian cancer. J Control Release. 243:250–268. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Chuffa LG, Lupi-Junior LA, Costa AB, Amorim JP and Seiva FR: The role of sex hormones and steroid receptors on female reproductive cancers. Steroids. 118:93–108. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Beral V; Million Women Study Collaborators, ; Bull D, Green J and Reeves G: Ovarian cancer and hormone replacement therapy in the Million Women Study. Lancet. 369:1703–1710. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Kurian AW, Balise RR, McGuire V and Whittemore AS: Histologic types of epithelial ovarian cancer: Have they different risk factors? Gynecol Oncol. 96:520–530. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Rice LW: Hormone prevention strategies for breast, endometrial and ovarian cancers. Gynecol Oncol. 118:202–207. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Schock H, Surcel HM, Zeleniuch-Jacquotte A, Grankvist K, Lakso HÅ, Fortner RT, Kaaks R, Pukkala E, Lehtinen M, Toniolo P and Lundin E: Early pregnancy sex steroids and maternal risk of epithelial ovarian cancer. Endocr Relat Cancer. 21:831–844. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Trabert B, Brinton LA, Anderson GL, Pfeiffer RM, Falk RT, Strickler HD, Sliesoraitis S, Kuller LH, Gass ML, Fuhrman BJ, et al: Circulating estrogens and postmenopausal ovarian cancer risk in the Women's Health initiative observational study. Cancer Epidemiol Biomarkers Prev. 25:648–656. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Svoboda M, Wlcek K, Taferner B, Hering S, Stieger B, Tong D, Zeillinger R, Thalhammer T and Jäger W: Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: Relevance for paclitaxel transport. Biomed Pharmacother. 65:417–426. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Sasano H, Miki Y, Nagasaki S and Suzuki T: In situ estrogen production and its regulation in human breast carcinoma: From endocrinology to intracrinology. Pathol Int. 59:777–789. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Suzuki T, Miki Y, Nakamura Y, Ito K and Sasano H: Steroid sulfatase and estrogen sulfotransferase in human carcinomas. Mol Cell Endocrinol. 340:148–153. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Ren X, Wu X, Hillier SG, Fegan KS, Critchley HO, Mason JI, Sarvi S and Harlow CR: Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy. J Steroid Biochem Mol Biol. 150:54–63. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Rizner TL: Estrogen biosynthesis, phase I and phase II metabolism, and action in endometrial cancer. Mol Cell Endocrinol. 381:124–139. 2013. View Article : Google Scholar : PubMed/NCBI

16 

McNamara KM and Sasano H: The intracrinology of breast cancer. J Steroid Biochem Mol Biol. 145:172–178. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Müller P, Rothschild SI, Arnold W, Hirschmann P, Horvath L, Bubendorf L, Savic S and Zippelius A: Metastatic spread in patients with non-small cell lung cancer is associated with a reduced density of tumor-infiltrating T cells. Cancer Immunol Immunother. 65:1–11. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Hanamura T, Niwa T, Gohno T, Kurosumi M, Takei H, Yamaguchi Y, Ito K and Hayashi S: Possible role of the aromatase-independent steroid metabolism pathways in hormone responsive primary breast cancers. Breast Cancer Res Treat. 143:69–80. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Chura JC, Blomquist CH, Ryu HS and Argenta PA: Estrone sulfatase activity in patients with advanced ovarian cancer. Gynecol Oncol. 112:205–209. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Hevir N, Ribič-Pucelj M and Lanišnik Rižner T: Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis: A source of excessive hydroxy-estrogens and ROS? Mol Cell Endocrinol. 367:74–84. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Xu Y, Liu X, Guo F, Ning Y, Zhi X, Wang X, Chen S, Yin L and Li X: Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers. Cancer Sci. 103:1000–1009. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Utsunomiya H, Ito K, Suzuki T, Kitamura T, Kaneko C, Nakata T, Niikura H, Okamura K, Yaegashi N and Sasano H: Steroid sulfatase and estrogen sulfotransferase in human endometrial carcinoma. Clin Cancer Res. 10:5850–5856. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Purohit A, Woo LW and Potter BV: Steroid sulfatase: A pivotal player in estrogen synthesis and metabolism. Mol Cell Endocrinol. 340:154–160. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Mungenast F and Thalhammer T: Estrogen biosynthesis and action in ovarian cancer. Front Endocrinol (Lausanne). 5:1922014.PubMed/NCBI

25 

Park SH, Cheung LW, Wong AS and Leung PC: Estrogen regulates Snail and Slug in the down-regulation of E-cadherin and induces metastatic potential of ovarian cancer cells through estrogen receptor alpha. Mol Endocrinol. 22:2085–2098. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Haring J, Schuler S, Lattrich C, Ortmann O and Treeck O: Role of estrogen receptor β in gynecological cancer. Gynecol Oncol. 127:673–676. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Voutsadakis IA: Hormone receptors in serous ovarian carcinoma: Prognosis, pathogenesis, and treatment considerations. Clin Med Insights Oncol. 10:17–25. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Silverberg SG: Histopathologic grading of ovarian carcinoma: A review and proposal. Int J Gynecol Pathol. 19:7–15. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Aust S, Bachmayr-Heyda A, Pateisky P, Tong D, Darb-Esfahani S, Denkert C, Chekerov R, Sehouli J, Mahner S, van Gorp T, et al: Role of TRAP1 and estrogen receptor alpha in patients with ovarian cancer-a study of the OVCAD consortium. Mol Cancer. 11:692012. View Article : Google Scholar : PubMed/NCBI

30 

Kounnis V, Ioachim E, Svoboda M, Tzakos A, Sainis I, Thalhammer T, Steiner G and Briasoulis E: Expression of organic anion-transporting polypeptides 1B3, 1B1, and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets. Onco Targets Ther. 4:27–32. 2011.PubMed/NCBI

31 

Remmele W and Stegner HE: Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe. 8:138–140. 1987.(In German). PubMed/NCBI

32 

Chekerov R, Braicu I, Castillo-Tong DC, Richter R, Cadron I, Mahner S, Woelber L, Marth C, van Gorp T, Speiser P, et al: Outcome and clinical management of 275 patients with advanced ovarian cancer International Federation of Obstetrics and Gynecology II to IV inside the European Ovarian Cancer Translational Research Consortium-OVCAD. Int J Gynecol Cancer. 23:268–275. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Kobel M, Kalloger SE, Boyd N, McKinney S, Mehl E, Palmer C, Leung S, Bowen NJ, Ionescu DN, Rajput A, et al: Ovarian carcinoma subtypes are different diseases: Implications for biomarker studies. PLoS Med. 5:e2322008. View Article : Google Scholar : PubMed/NCBI

34 

Rizner TL: The important roles of steroid sulfatase and sulfotransferases in gynecological diseases. Front Pharmacol. 7:302016. View Article : Google Scholar : PubMed/NCBI

35 

Smuc T and Rizner TL: Aberrant pre-receptor regulation of estrogen and progesterone action in endometrial cancer. Mol Cell Endocrinol. 301:74–82. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Li L, He D, Wilborn TW, Falany JL and Falany CN: Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylation. Steroids. 74:20–29. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Falany CN, Comer KA, Dooley TP and Glatt H: Human dehydroepiandrosterone sulfotransferase. Purification, molecular cloning, and characterization. Ann N Y Acad Sci. 774:59–72. 1995. View Article : Google Scholar : PubMed/NCBI

38 

Adjei AA and Weinshilboum RM: Catecholestrogen sulfation: Possible role in carcinogenesis. Biochem Biophys Res Commun. 292:402–408. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Abulafia O, Lee YC, Wagreich A, Economos K, Serur E and Nacharaju VL: Sulfatase activity in normal and neoplastic endometrium. Gynecol Obstet Invest. 67:57–60. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Tanaka K, Kubushiro K, Iwamori Y, Okairi Y, Kiguchi K, Ishiwata I, Tsukazaki K, Nozawa S and Iwamori M: Estrogen sulfotransferase and sulfatase: Roles in the regulation of estrogen activity in human uterine endometrial carcinomas. Cancer Sci. 94:871–876. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Purohit A, Fusi L, Brosens J, Woo LW, Potter BV and Reed MJ: Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE: A potential new therapy. Hum Reprod. 23:290–297. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Reed MJ, Purohit A, Woo LW, Newman SP and Potter BV: Steroid sulfatase: Molecular biology, regulation, and inhibition. Endocr Rev. 26:171–202. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Zaichuk T, Ivancic D, Scholtens D, Schiller C and Khan SA: Tissue-specific transcripts of human steroid sulfatase are under control of estrogen signaling pathways in breast carcinoma. J Steroid Biochem Mol Biol. 105:76–84. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Jonsson JM, Arildsen N Skovbjerg, Malander S, Måsbäck A, Hartman L, Nilbert M and Hedenfalk I: Sex steroid hormone receptor expression affects ovarian cancer survival. Transl Oncol. 8:424–433. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Lin SX, Chen J, Mazumdar M, Poirier D, Wang C, Azzi A and Zhou M: Molecular therapy of breast cancer: Progress and future directions. Nat Rev Endocrinol. 6:485–493. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Foster PA, Woo LW, Potter BV, Reed MJ and Purohit A: The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer. Endocrinology. 149:4035–4042. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Chanplakorn N, Chanplakorn P, Suzuki T, Ono K, Chan MS, Miki Y, Saji S, Ueno T, Toi M and Sasano H: Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients. Breast Cancer Res Treat. 120:639–648. 2010. View Article : Google Scholar : PubMed/NCBI

48 

Day JM, Purohit A, Tutill HJ, Foster PA, Woo LW, Potter BV and Reed MJ: The development of steroid sulfatase inhibitors for hormone-dependent cancer therapy. Ann N Y Acad Sci. 1155:80–87. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Falany JL and Falany CN: Regulation of SULT1E1 expression in Ishikawa adenocarcinoma cells by tibolone. Steroids. 71:880–885. 2006. View Article : Google Scholar : PubMed/NCBI

50 

Hormone Health Network: Menopause, . http://www.hormone.org/diseases-and-conditions/womens-health/menopauseJanuary 17–2017.

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Copy and paste a formatted citation
Spandidos Publications style
Mungenast F, Aust S, Vergote I, Vanderstichele A, Sehouli J, Braicu E, Mahner S, Castillo‑Tong DC, Zeillinger R, Thalhammer T, Thalhammer T, et al: Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer. Oncol Lett 13: 4047-4054, 2017.
APA
Mungenast, F., Aust, S., Vergote, I., Vanderstichele, A., Sehouli, J., Braicu, E. ... Thalhammer, T. (2017). Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer. Oncology Letters, 13, 4047-4054. https://doi.org/10.3892/ol.2017.5969
MLA
Mungenast, F., Aust, S., Vergote, I., Vanderstichele, A., Sehouli, J., Braicu, E., Mahner, S., Castillo‑Tong, D. C., Zeillinger, R., Thalhammer, T."Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer". Oncology Letters 13.6 (2017): 4047-4054.
Chicago
Mungenast, F., Aust, S., Vergote, I., Vanderstichele, A., Sehouli, J., Braicu, E., Mahner, S., Castillo‑Tong, D. C., Zeillinger, R., Thalhammer, T."Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer". Oncology Letters 13, no. 6 (2017): 4047-4054. https://doi.org/10.3892/ol.2017.5969
Copy and paste a formatted citation
x
Spandidos Publications style
Mungenast F, Aust S, Vergote I, Vanderstichele A, Sehouli J, Braicu E, Mahner S, Castillo‑Tong DC, Zeillinger R, Thalhammer T, Thalhammer T, et al: Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer. Oncol Lett 13: 4047-4054, 2017.
APA
Mungenast, F., Aust, S., Vergote, I., Vanderstichele, A., Sehouli, J., Braicu, E. ... Thalhammer, T. (2017). Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer. Oncology Letters, 13, 4047-4054. https://doi.org/10.3892/ol.2017.5969
MLA
Mungenast, F., Aust, S., Vergote, I., Vanderstichele, A., Sehouli, J., Braicu, E., Mahner, S., Castillo‑Tong, D. C., Zeillinger, R., Thalhammer, T."Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer". Oncology Letters 13.6 (2017): 4047-4054.
Chicago
Mungenast, F., Aust, S., Vergote, I., Vanderstichele, A., Sehouli, J., Braicu, E., Mahner, S., Castillo‑Tong, D. C., Zeillinger, R., Thalhammer, T."Clinical significance of the estrogen-modifying enzymes steroid sulfatase and estrogen sulfotransferase in epithelial ovarian cancer". Oncology Letters 13, no. 6 (2017): 4047-4054. https://doi.org/10.3892/ol.2017.5969
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