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High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma

  • Authors:
    • Da Ma
    • Juan Fang
    • Ying Liu
    • Jing‑Jing Song
    • Yan‑Qiong Wang
    • Juan Xia
    • Bin Cheng
    • Zhi Wang
  • View Affiliations / Copyright

    Affiliations: Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Oral Diseases, Sun Yat‑Sen University, Guangzhou, Guangdong 510055, P.R. China, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637100, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4017-4026
    |
    Published online on: April 3, 2017
       https://doi.org/10.3892/ol.2017.5970
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Abstract

Calpain1, termed conventional calpain and a member of the Ca2+-dependent neutral cysteine proteases, is considered to be involved in cancer formation and development. However, the effect of calpain1 on oral squamous cell carcinoma (OSCC) remains poorly understood. The aim of the present study was to evaluate the possibility of calpain1 as a potential molecular target for OSCC diagnosis and therapy. The present study demonstrates that calpain1 was overexpressed in OSCC cell lines and 4/7 of the tumor tissues in paired samples of tumor and noncancerous matched tissues (NCMT). In a cohort of 125 patients with primary OSCC, the high expression of calpain1 was an independent predictor for overall survival in a multivariate analysis (P=0.022). Furthermore, RNA interference‑mediated suppression of calpain1 expression reduced the proliferation, migration and invasion potential of the HSC3 and CAL27 OSCC cell lines, but did not increase their apoptosis. These findings indicate that calpain1 may be a useful biomarker for novel prognostic and therapeutic strategies in oral squamous cell carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Ma D, Fang J, Liu Y, Song JJ, Wang YQ, Xia J, Cheng B and Wang Z: High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. Oncol Lett 13: 4017-4026, 2017.
APA
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J. ... Wang, Z. (2017). High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. Oncology Letters, 13, 4017-4026. https://doi.org/10.3892/ol.2017.5970
MLA
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J., Cheng, B., Wang, Z."High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma". Oncology Letters 13.6 (2017): 4017-4026.
Chicago
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J., Cheng, B., Wang, Z."High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma". Oncology Letters 13, no. 6 (2017): 4017-4026. https://doi.org/10.3892/ol.2017.5970
Copy and paste a formatted citation
x
Spandidos Publications style
Ma D, Fang J, Liu Y, Song JJ, Wang YQ, Xia J, Cheng B and Wang Z: High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. Oncol Lett 13: 4017-4026, 2017.
APA
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J. ... Wang, Z. (2017). High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma. Oncology Letters, 13, 4017-4026. https://doi.org/10.3892/ol.2017.5970
MLA
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J., Cheng, B., Wang, Z."High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma". Oncology Letters 13.6 (2017): 4017-4026.
Chicago
Ma, D., Fang, J., Liu, Y., Song, J., Wang, Y., Xia, J., Cheng, B., Wang, Z."High level of calpain1 promotes cancer cell invasion and migration in oral squamous cell carcinoma". Oncology Letters 13, no. 6 (2017): 4017-4026. https://doi.org/10.3892/ol.2017.5970
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