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Article

Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer

  • Authors:
    • Xiao‑Chuan Ge
    • Fan Wu
    • Wei‑Tao Li
    • Xuan‑Jin Zhu
    • Jian‑Wei Liu
    • Bai‑Lin Wang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University, Guangzhou, Guangdong 510220, P.R. China
  • Pages: 4341-4348
    |
    Published online on: April 4, 2017
       https://doi.org/10.3892/ol.2017.5984
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Abstract

WEE1 is a serine/threonine protein kinase that inactivates cell division cycle 2 and is therefore a critical cell cycle regulator. Increased WEE1 expression has been observed in numerous types of human malignancies, including hepatocellular carcinoma and melanoma. WEE1 inhibition also results in evident anti‑tumor effects in several human tumor cells including colon cancer cells, suggesting WEE1 as a potential therapeutic target for the treatment of cancer. However, the expression pattern of WEE1 in colorectal cancer (CRC) remains unclear. In the present study, WEE1 mRNA expression in 43 cases of CRC tissues matched with adjacent normal tissues was determined by reverse‑transcription quantitative polymerase chain reaction. The results demonstrated that WEE1 mRNA expression was significantly increased in CRC tissues and that this upregulation correlated significantly with hepatic metastasis, distant metastasis and high tumor node metastasis (TNM) stage of CRC. Additionally, WEE1 protein in 102 CRC tissue samples was detected by immunohistochemistry, and positive staining of WEE1 was identified in more than half of patients with CRC. WEE1 staining scores were also observed to be associated with distant metastasis and high TNM stage of CRC. In addition, patients with CRC with high WEE1 staining score (2+ or 3+) exhibited either poorer overall survival or poorer disease‑free survival compared with those with low WEE1 staining score (0 or 1+). The multivariable Cox model also identified a high WEE1 staining score as well as high TNM stage to be independent prognostic factors for CRC. In conclusion, WEE1 upregulation is associated with a high degree of malignancy and poor prognosis of CRC, suggesting WEE1 as a potential prognostic biomarker for CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Ge XC, Wu F, Li WT, Zhu XJ, Liu JW and Wang BL: Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer. Oncol Lett 13: 4341-4348, 2017.
APA
Ge, X., Wu, F., Li, W., Zhu, X., Liu, J., & Wang, B. (2017). Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer. Oncology Letters, 13, 4341-4348. https://doi.org/10.3892/ol.2017.5984
MLA
Ge, X., Wu, F., Li, W., Zhu, X., Liu, J., Wang, B."Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer". Oncology Letters 13.6 (2017): 4341-4348.
Chicago
Ge, X., Wu, F., Li, W., Zhu, X., Liu, J., Wang, B."Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer". Oncology Letters 13, no. 6 (2017): 4341-4348. https://doi.org/10.3892/ol.2017.5984
Copy and paste a formatted citation
x
Spandidos Publications style
Ge XC, Wu F, Li WT, Zhu XJ, Liu JW and Wang BL: Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer. Oncol Lett 13: 4341-4348, 2017.
APA
Ge, X., Wu, F., Li, W., Zhu, X., Liu, J., & Wang, B. (2017). Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer. Oncology Letters, 13, 4341-4348. https://doi.org/10.3892/ol.2017.5984
MLA
Ge, X., Wu, F., Li, W., Zhu, X., Liu, J., Wang, B."Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer". Oncology Letters 13.6 (2017): 4341-4348.
Chicago
Ge, X., Wu, F., Li, W., Zhu, X., Liu, J., Wang, B."Upregulation of WEE1 is a potential prognostic biomarker for patients with colorectal cancer". Oncology Letters 13, no. 6 (2017): 4341-4348. https://doi.org/10.3892/ol.2017.5984
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