Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2017 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2017 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis

  • Authors:
    • Changqing Zeng
    • Xingyu Feng
    • Wei Wang
    • Lin Lv
    • Cheng Fang
    • Liangjie Chi
    • Liangxiang Huang
    • Zhiwei Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Gastric Surgery, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of General Surgery, Guangdong General Hospital, Guangdong Academy of Medical Science, Guangzhou, Guangdong 510060, P.R. China, Department of Oncology, Guangzhou First People's Hospital, Guangzhou, Guangdong 510180, P.R. China, Department of Gastrointestinal Surgery, Fujian Provincial Hospital, Provincial Clinical Medical College of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China
    Copyright: © Zeng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4161-4168
    |
    Published online on: April 5, 2017
       https://doi.org/10.3892/ol.2017.5993
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the expression and prognostic significance of insulin‑like growth factor binding protein 6 (IGFBP-6) in gastric adenocarcinoma. The expression of IGFBP‑6 was examined in 263 specimens from gastric adenocarcinoma patients using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR), western blotting and immunohistochemical (IHC) staining. The association between IGFBP‑6 expression, clinicopathological factors and clinical outcomes was investigated. Akaike information criterion (AIC) and Harrell’s concordance index (c‑index) were used to evaluate the accuracy of the predictive prognosis. RT‑qPCR and western blotting results showed that IGFBP‑6 mRNA expression was lower in the tumors compared with that in adjacent non‑tumor tissues. IGFBP‑6 showed significantly decreased expression in 170 out of 263 patients based on IHC data and this was associated with a larger tumor size (P<0.001) and poorly‑differentiated adenocarcinoma (P=0.001), as well as with palliative gastrectomy (P=0.015). Additionally, decreased expression of IGFBP‑6 was associated with stage T3/4a/4b disease and lymph node‑positive metastasis (P<0.001). The association between decreased expression and a poor prognosis was revealed by Kaplan‑Meier curves. Cox regression model identified IGFBP‑6 as an independent prognostic factor. The prognostic value of the model with IGFBP‑6 expression (AIC, 924.881; c‑index, 0.878) was superior to that without IGFBP‑6 expression (AIC, 947.164; c‑index, 0.825). In conclusion, IGFBP‑6 involves the development and progression of gastric adenocarcinoma, and its decreased expression predicts poor clinical outcomes.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Siegel R, Ward E, Hao Y, Xu J and Thun MJ: Cancer statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Hartgrink HH, Jansen EP, van Grieken NC and van de Velde CJ: Gastric cancer. Lancet. 374:477–490. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Nobili S, Bruno L, Landini I, Napoli C, Bechi P, Tonelli F, Rubio CA, Mini E and Nesi G: Genomic and genetic alterations influence the progression of gastric cancer. World J Gastroenterol. 17:290–299. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Chen CN, Lin JJ, Chen JJ, Lee PH, Yang CY, Kuo ML, Chang KJ and Hsieh FJ: Gene expression profile predicts patient survival of gastric cancer after surgical resection. J Clin Oncol. 23:7286–7295. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Yasui W, Oue N, Aung PP, Matsumura S, Shutoh M and Nakayama H: Molecular-pathological prognostic factors of gastric cancer: A review. Gastric Cancer. 8:86–94. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Lee HS, Cho SB, Lee HE, Kim MA, Kim JH, Park DJ, Kim JH, Yang HK, Lee BL and Kim WH: Protein expression profiling and molecular classification of gastric cancer by the tissue array method. Clin Cancer Res. 13:4154–4163. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Oue N, Hamai Y, Mitani Y, Matsumura S, Oshimo Y, Aung PP, Kuraoka K, Nakayama H and Yasui W: Gene expression profile of gastric carcinoma: Identification of genes and tags potentially involved in invasion, metastasis, and carcinogenesis by serial analysis of gene expression. Cancer Res. 64:2397–2405. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Hippo Y, Taniguchi H, Tsutsumi S, Machida N, Chong JM, Fukayama M, Kodama T and Aburatani H: Global gene expression analysis of gastric cancer by oligonucleotide microarrays. Cancer Res. 62:233–240. 2002.PubMed/NCBI

10 

Yasui W, Oue N, Sentani K, Sakamoto N and Motoshita J: Transcriptome dissection of gastric cancer: Identification of novel diagnostic and therapeutic targets from pathology specimens. Pathol Int. 59:121–136. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Iosef C, Vilk G, Gkourasas T, Lee KJ, Chen BP, Fu P, Bach LA, Lajoie G, Gupta MB, Li SS and Han VK: Insulin-like growth factor binding protein-6 (IGFBP-6) interacts with DNA-end binding protein Ku80 to regulate cell fate. Cell Signal. 22:1033–1043. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Minniti CP, Luan D, O'Grady C, Rosenfeld RG, Oh Y and Helman LJ: Insulin-like growth factor II overexpression in myoblasts induces phenotypic changes typical of the malignant phenotype. Cell Growth Differ. 6:263–269. 1995.PubMed/NCBI

13 

Osborne CK, Coronado EB, Kitten LJ, Arteaga CI, Fuqua SA, Ramasharma K, Marshall M and Li CH: Insulin-likegrowth factor-II (IGF-II): A potential autocrine/paracrine growth factor forhuman breast cancer acting via the IGF-I receptor. Mol Endocrinol. 3:1701–1709. 1989. View Article : Google Scholar : PubMed/NCBI

14 

Thompson MA, Cox AJ, Whitehead RH and Jonas HA: Autocrine regulation of human tumor cell proliferation by insulin-like growth factor II: An in-vitro model. Endocrinology. 126:3033–3042. 1990. View Article : Google Scholar : PubMed/NCBI

15 

Christofori G, Naik P and Hanahan D: A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesis. Nature. 369:414–418. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Cullen KJ, Allison A, Martire I, Ellis M and Singer C: Insulin-like growth factor expression in breast cancer epithelium and stroma. Breast Cancer Res Treat. 22:21–29. 1992. View Article : Google Scholar : PubMed/NCBI

17 

Ho MN, Delgado CH, Owens GA and Steller MA: Insulin-like growth factor-II participates in the biphasic effect of a gonadotropin-releasing hormone agonist on ovarian cancer cell growth. Fertil Steril. 67:870–876. 1997. View Article : Google Scholar : PubMed/NCBI

18 

Firth SM and Baxter RC: Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev. 23:824–854. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Kiefer MC, Schmid C, Waldvogel M, Schläpfer I, Futo E, Masiarz FR, Green K, Barr PJ and Zapf J: Characterization of recombinant human insulin-like growth factor binding proteins 4, 5, and 6 produced in yeast. J Biol Chem. 267:12692–12699. 1992.PubMed/NCBI

20 

Bach LA: IGFBP-6 five years on; not so ‘forgotten’? Growth Horm IGF Res. 15:185–192. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Bach LA, Hsieh S, Brown AL and Rechler MM: Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts. Endocrinology. 135:2168–2176. 1994. View Article : Google Scholar : PubMed/NCBI

22 

Dake BL, Boes M, Bach LA and Bar RS: Effect of an insulin-like growth factor binding protein fusion protein on thymidine incorporation in neuroblastoma and rhabdomyosarcoma cell lines. Endocrinology. 145:3369–3374. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Gallicchio MA, Kaun C, Wojta J, Binder B and Bach LA: Urokinase type plasminogen activator receptor is involved in insulin-like growth factor-induced migration of rhabdomyosarcoma cells in vitro. J Cell Physiol. 197:131–138. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Gallicchio MA, Kneen M, Hall C, Scott AM and Bach LA: Overexpression of insulin-like growth factor binding protein-6 inhibits rhabdomyosarcoma growth in vivo. Int J Cancer. 94:645–651. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Kim EJ, Kang YH, Schaffer BS, Bach LA, MacDonald RG and Park JH: Inhibition of Caco-2 cell proliferation by all-trans retinoic acid: Role of insulin-like growth factor binding protein-6. J Cell Physiol. 190:92–100. 2001. View Article : Google Scholar

26 

Mohan S and Baylink DJ: IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms. J Endocrinol. 175:19–31. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Sueoka N, Lee HY, Wiehle S, Cristiano RJ, Fang B, Ji L, Roth JA, Hong WK, Cohen P and Kurie JM: Insulin-like growth factor binding protein-6 activates programmed cell death in non-small cell lung cancer cells. Oncogene. 19:4432–4436. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Sano T: Evaluation of the gastric cancer treatment guidelines of the Japanese Gastric Cancer Association. Gan To Kagaku Ryoho. 37:582–586. 2010.(In Japanese). PubMed/NCBI

29 

Berlth F, Bollschweiler E, Drebber U, Hoelscher AH and Moenig S: Pathohistological classification systems in gastric cancer: Diagnostic relevance and prognostic value. World J Gastroenterol. 20:5679–5684. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Wittekind C: 2010 TNM system: On the 7th edition of TNM classification of malignant tumors. Pathologe. 31:331–332. 2010.(In German). View Article : Google Scholar : PubMed/NCBI

31 

Livak and Schmittgen: Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Wang W, Lv L, Pan K, Zhang Y, Zhao JJ, Chen JG, Chen YB, Li YQ, Wang QJ, He J, et al: Reduced expression of transcription factor AP-2α is associated with gastric adenocarcinoma prognosis. PLoS One. 6:e248972011. View Article : Google Scholar : PubMed/NCBI

33 

Li YF, Wang DD, Zhao BW, Wang W, Yuan SQ, Huang CY, Chen YM, Zheng Y, Keshari RP, et al: Poor prognosis of gastric adenocarcinoma with decreased expression of AHRR. PLoS One. 7:e435552012. View Article : Google Scholar : PubMed/NCBI

34 

Huang CY, Chen YM, Zhao JJ, Chen YB, Jiang SS, Yan SM, Zhao BW, Pan K, Wang DD, Lv L, et al: Decreased expression of transcription elongation factor A-like 7 is associated with gastric adenocarcinoma prognosis. PLoS One. 8:e546712013. View Article : Google Scholar : PubMed/NCBI

35 

El-Badry OM, Romanus JA, Helman LJ, Cooper MJ, Rechler MM and Israel MA: Autonomous growth of a human neuroblastoma cell line is mediated by insulin-like growth factor II. J Clin Invest. 84:829–839. 1989. View Article : Google Scholar : PubMed/NCBI

36 

Stewart CE and Rotwein P: Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors. Physiol Rev. 76:1005–1026. 1996.PubMed/NCBI

37 

Toretsky JA and Helman LJ: Involvement of IGF-II in human cancer. J Endocrinol. 149:367–372. 1996. View Article : Google Scholar : PubMed/NCBI

38 

LeRoith D, Baserga R, Helman L and Roberts CT Jr: Insulin-like growth factors and cancer. Ann Intern Med. 122:54–59. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Lu L, Katsaros D, Wiley A, de la Longrais IA Rigault, Risch HA, Puopolo M and Yu H: The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer. Clin Cancer Res. 12:1208–1214. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Denley A, Wallace JC, Cosgrove LJ and Forbes BE: The insulin receptor isoform exon 11-(IR-A) in cancer and other diseases: A review. Horm Metab Res. 35:778–785. 2003. View Article : Google Scholar : PubMed/NCBI

41 

Frasca F, Pandini G, Scalia P, Sciacca L, Mineo R, Costantino A, Goldfine ID, Belfiore A and Vigneri R: Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol. 19:3278–3288. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Kalli KR, Falowo OI, Bale LK, Zschunke MA, Roche PC and Conover CA: Functional insulin receptors on human epithelial ovarian carcinoma cells: Implications for IGF-II mitogenic signaling. Endocrinology. 143:3259–3267. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Sciacca L, Mineo R, Pandini G, Murabito A, Vigneri R and Belfiore A: In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Oncogene. 21:8240–8250. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Vella V, Pandini G, Sciacca L, Mineo R, Vigneri R, Pezzino V and Belfiore A: A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. J Clin Endocrinol Metab. 87:245–254. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Bach LA: Insulin-like growth factor binding protein-6: The ‘forgotten’ binding protein? Horm Metab Res. 31:226–234. 1999. View Article : Google Scholar : PubMed/NCBI

46 

Kuo YS, Tang YB, Lu TY, Wu HC and Lin CT: IGFBP-6 plays a role as an oncosuppressor gene in NPC pathogenesis through regulating EGR-1 expression. J Pathol. 222:299–309. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Leng SL, Leeding KS, Whitehead RH and Bach LA: Insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced but not basal proliferation and adhesion of LIM 1215 colon cancer cells. Mol Cell Endocrinol. 174:121–127. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Saeki N, Ono H, Sakamoto H and Yoshida T: Genetic factors related to gastric cancer susceptibility identified using a genome-wide association study. Cancer Sci. 104:1–8. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Nagini S: Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol. 4:156–169. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zeng C, Feng X, Wang W, Lv L, Fang C, Chi L, Huang L and Zhou Z: Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis. Oncol Lett 13: 4161-4168, 2017.
APA
Zeng, C., Feng, X., Wang, W., Lv, L., Fang, C., Chi, L. ... Zhou, Z. (2017). Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis. Oncology Letters, 13, 4161-4168. https://doi.org/10.3892/ol.2017.5993
MLA
Zeng, C., Feng, X., Wang, W., Lv, L., Fang, C., Chi, L., Huang, L., Zhou, Z."Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis". Oncology Letters 13.6 (2017): 4161-4168.
Chicago
Zeng, C., Feng, X., Wang, W., Lv, L., Fang, C., Chi, L., Huang, L., Zhou, Z."Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis". Oncology Letters 13, no. 6 (2017): 4161-4168. https://doi.org/10.3892/ol.2017.5993
Copy and paste a formatted citation
x
Spandidos Publications style
Zeng C, Feng X, Wang W, Lv L, Fang C, Chi L, Huang L and Zhou Z: Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis. Oncol Lett 13: 4161-4168, 2017.
APA
Zeng, C., Feng, X., Wang, W., Lv, L., Fang, C., Chi, L. ... Zhou, Z. (2017). Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis. Oncology Letters, 13, 4161-4168. https://doi.org/10.3892/ol.2017.5993
MLA
Zeng, C., Feng, X., Wang, W., Lv, L., Fang, C., Chi, L., Huang, L., Zhou, Z."Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis". Oncology Letters 13.6 (2017): 4161-4168.
Chicago
Zeng, C., Feng, X., Wang, W., Lv, L., Fang, C., Chi, L., Huang, L., Zhou, Z."Decreased expression of insulin-like growth factor binding protein 6 is associated with gastric adenocarcinoma prognosis". Oncology Letters 13, no. 6 (2017): 4161-4168. https://doi.org/10.3892/ol.2017.5993
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team