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Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells

  • Authors:
    • Holger Bronger
    • Anne Karge
    • Tobias Dreyer
    • Daniela Zech
    • Sara Kraeft
    • Stefanie Avril
    • Marion Kiechle
    • Manfred Schmitt
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Technical University of Munich, D‑81675 Munich, Germany, Department of Pathology, Technical University of Munich, D‑81675 Munich, Germany
    Copyright: © Bronger et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4224-4230
    |
    Published online on: April 5, 2017
       https://doi.org/10.3892/ol.2017.5994
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Abstract

Cathepsin B (CTSB) is a lysosomal cysteine protease that has been linked to the progression of breast cancer, for example by activation of other proteases and tumor‑promoting cytokines, thereby supporting tumor invasion and metastasis. Previously, it was shown that CTSB cleaves and inactivates C‑X‑C motif chemokine receptor 3 (CXCR3) chemokines. As CXCR3 ligands have been demonstrated to induce proteases in cancer cells, the present study hypothesized that they may also affect CTSB in breast cancer cells. The results demonstrated that the human breast cancer tumor cell lines MCF‑7 and MDA‑MB‑231 express the CXCR3 splice variants A and B and CTSB. Upon binding to CXCR3, the two chemokine ligands C‑X‑C motif chemokine ligand (CXCL) 9 and CXCL10 trigger upregulation of CTSB in these breast cancer cells, whereas the CXCR3‑B‑specific ligand CXCL4 has no such effect, suggesting the involvement of CXCR3‑A in the regulation of CTSB. In early‑stage human breast cancer specimens (n=81), overexpression of CXCR3 is associated with statistically significant poorer overall survival, independent of lymph node status, tumor size and nuclear grading (hazard ratio=1.99; 95% confidence interval=1.00‑3.97; P=0.050). In conclusion, the data from the current study propose a so far unknown mechanism by which breast cancer cells may exploit tumor‑suppressive chemokines to enhance their invasiveness and reduce immune cell infiltration by the degradation of these chemokines. This mechanism may support the established unfavorable prognostic feature of CXCR3 expression in breast cancer.
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1 

Yan S and Sloane BF: Molecular regulation of human cathepsin B: Implication in pathologies. Biol Chem. 384:845–854. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Roshy S, Sloane BF and Moin K: Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev. 22:271–286. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Aggarwal N and Sloane BF: Cathepsin B: Multiple roles in cancer. Proteomics Clin Appl. 8:427–437. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Olson OC and Joyce JA: Cysteine cathepsin proteases: Regulators of cancer progression and therapeutic response. Nat Rev Cancer. 15:712–729. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Kos J, Mitrović A and Mirković B: The current stage of cathepsin B inhibitors as potential anticancer agents. Future Med Chem. 6:1355–1371. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Vasiljeva O, Korovin M, Gajda M, Brodoefel H, Bojic L, Krüger A, Schurigt U, Sevenich L, Turk B, Peters C and Reinheckel T: Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice. Oncogene. 27:4191–4199. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Vasiljeva O, Papazoglou A, Krüger A, Brodoefel H, Korovin M, Deussing J, Augustin N, Nielsen BS, Almholt K, Bogyo M, et al: Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer. Cancer Res. 66:5242–5250. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Lah TT, Cercek M, Blejec A, Kos J, Gorodetsky E, Somers R and Daskal I: Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: Comparison with cathepsin Dcathepsin L, and other clinical indicators. Clin Cancer Res. 6:578–584. 2000.PubMed/NCBI

9 

Thomssen C, Schmitt M, Goretzki L, Oppelt P, Pache L, Dettmar P, Jänicke F and Graeff H: Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer. Clin Cancer Res. 1:741–746. 1995.PubMed/NCBI

10 

Maguire TM, Shering SG, Duggan CM, McDermott EW, O'Higgins NJ and Duffy MJ: High levels of cathepsin B predict poor outcome in patients with breast cancer. Int J Biol Markers. 13:139–144. 1998.PubMed/NCBI

11 

Foekens JA, Kos J, Peters HA, Krasovec M, Look MP, Cimerman N, Meijer-van Gelder ME, Henzen-Logmans SC, van Putten WL and Klijn JG: Prognostic significance of cathepsins B and L in primary human breast cancer. J Clin Oncol. 16:1013–1021. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Harbeck N, Alt U, Berger U, Krüger A, Thomssen C, Jänicke F, Höfler H, Kates RE and Schmitt M: Prognostic impact of proteolytic factors (urokinase-type plasminogen activator, plasminogen activator inhibitor 1, and cathepsins B, D, and L) in primary breast cancer reflects effects of adjuvant systemic therapy. Clin Cancer Res. 7:2757–2764. 2001.PubMed/NCBI

13 

Balaji KN, Schaschke N, Machleidt W, Catalfamo M and Henkart PA: Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. J Exp Med. 196:493–503. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Hasan L, Mazzucchelli L, Liebi M, Lis M, Hunger RE, Tester A, Overall CM and Wolf M: Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing. J Immunol. 176:6512–6522. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Repnik U, Starr AE, Overall CM and Turk B: Cysteine cathepsins activate ELR chemokines and inactivate non-ELR chemokines. J Biol Chem. 290:13800–13811. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Chen DS and Mellman I: Oncology meets immunology: The cancer-immunity cycle. Immunity. 39:1–10. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Wendel M, Galani IE, Suri-Payer E and Cerwenka A: Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands. Cancer Res. 68:8437–8445. 2008. View Article : Google Scholar : PubMed/NCBI

18 

da Silva R Barreira, Laird ME, Yatim N, Fiette L, Ingersoll MA and Albert ML: Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy. Nat Immunol. 16:850–858. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Shin SY, Nam JS, Lim Y and Lee YH: TNFα-exposed bone marrow-derived mesenchymal stem cells promote locomotion of MDA-MB-231 breast cancer cells through transcriptional activation of CXCR3 ligand chemokines. J Biol Chem. 285:30731–30740. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Zipin-Roitman A, Meshel T, Sagi-Assif O, Shalmon B, Avivi C, Pfeffer RM, Witz IP and Ben-Baruch A: CXCL10 promotes invasion-related properties in human colorectal carcinoma cells. Cancer Res. 67:3396–3405. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Jänicke F, Pache L, Schmitt M, Ulm K, Thomssen C, Prechtl A and Graeff H: Both the cytosols and detergent extracts of breast cancer tissues are suited to evaluate the prognostic impact of the urokinase-type plasminogen activator and its inhibitor, plasminogen activator inhibitor type 1. Cancer Res. 54:2527–2530. 1994.PubMed/NCBI

22 

Bronger H, König J, Kopplow K, Steiner HH, Ahmadi R, Herold-Mende C, Keppler D and Nies AT: ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Cancer Res. 65:11419–11428. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Bronger H, Kraeft S, Schwarz-Boeger U, Cerny C, Stöckel A, Avril S, Kiechle M and Schmitt M: Modulation of CXCR3 ligand secretion by prostaglandin E2 and cyclooxygenase inhibitors in human breast cancer. Breast Cancer Res. 14:R302012. View Article : Google Scholar : PubMed/NCBI

24 

Kaplan EL and Meier P: Nonparametric estimation from incomplete observations. J Amer Statist Assn. 53:457–481. 1958. View Article : Google Scholar

25 

Datta D, Flaxenburg JA, Laxmanan S, Geehan C, Grimm M, Waaga-Gasser AM, Briscoe DM and Pal S: Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: Relevance for the development of human breast cancer. Cancer Res. 66:9509–9518. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Ma X, Norsworthy K, Kundu N, Rodgers WH, Gimotty PA, Goloubeva O, Lipsky M, Li Y, Holt D and Fulton A: CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model. Mol Cancer Ther. 8:490–498. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Cerny C, Bronger H, Davoodi M, Sharma S, Zhu L, Obana S, Sharma J, Ebrahimi R, St John M, Lee JM, et al: The role of CXCR3/ligand axis in cancer. International Trends in Immunity. 3:46–52. 2015. View Article : Google Scholar

28 

Ma B, Khazali A and Wells A: CXCR3 in carcinoma progression. Histol Histopathol. 30:781–792. 2015.PubMed/NCBI

29 

Denkert C, Loibl S, Noske A, Roller M, Müller BM, Komor M, Budczies J, Darb-Esfahani S, Kronenwett R, Hanusch C, et al: Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol. 28:105–113. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Denkert C, von Minckwitz G, Brase JC, Sinn BV, Gade S, Kronenwett R, Pfitzner BM, Salat C, Loi S, Schmitt WD, et al: Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without Carboplatin in human epidermal growth factor receptor 2-positive and triple-negative primary breast cancers. J Clin Oncol. 33:983–991. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Specht K, Harbeck N, Smida J, Annecke K, Reich U, Naehrig J, Langer R, Mages J, Busch R, Kruse E, et al: Expression profiling identifies genes that predict recurrence of breast cancer after adjuvant CMF-based chemotherapy. Breast Cancer Res Treat. 118:45–56. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Dorsey R, Kundu N, Yang Q, Tannenbaum CS, Sun H, Hamilton TA and Fulton AM: Immunotherapy with interleukin-10 depends on the CXC chemokines inducible protein-10 and monokine induced by IFN-gamma. Cancer Res. 62:2606–2610. 2002.PubMed/NCBI

33 

Walser TC, Ma X, Kundu N, Dorsey R, Goloubeva O and Fulton AM: Immune-mediated modulation of breast cancer growth and metastasis by the chemokine Mig (CXCL9) in a murine model. J Immunother. 30:490–498. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Walser TC, Rifat S, Ma X, Kundu N, Ward C, Goloubeva O, Johnson MG, Medina JC, Collins TL and Fulton AM: Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res. 66:7701–7707. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A and Weinberg RA: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927–939. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Hilborn E, Sivik T, Fornander T, Stål O, Nordenskjöld B and Jansson A: C-X-C ligand 10 and C-X-C receptor 3 status can predict tamoxifen treatment response in breast cancer patients. Breast Cancer Res Treat. 145:73–82. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Wolf K and Friedl P: Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin Exp Metastasis. 26:289–298. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Van den Steen PE, Husson SJ, Proost P, Van Damme J and Opdenakker G: Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase. Biochem Biophys Res Commun. 310:889–896. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Denney H, Clench MR and Woodroofe MN: Cleavage of chemokines CCL2 and CXCL10 by matrix metalloproteinases-2 and −9: Implications for chemotaxis. Biochem Biophys Res Commun. 382:341–347. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Zhu G, Yan HH, Pang Y, Jian J, Achyut BR, Liang X, Weiss JM, Wiltrout RH, Hollander MC and Yang L: CXCR3 as a molecular target in breast cancer metastasis: Inhibition of tumor cell migration and promotion of host anti-tumor immunity. Oncotarget. 6:43408–43419. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bronger H, Karge A, Dreyer T, Zech D, Kraeft S, Avril S, Kiechle M and Schmitt M: Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncol Lett 13: 4224-4230, 2017.
APA
Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S. ... Schmitt, M. (2017). Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncology Letters, 13, 4224-4230. https://doi.org/10.3892/ol.2017.5994
MLA
Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., Kiechle, M., Schmitt, M."Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells". Oncology Letters 13.6 (2017): 4224-4230.
Chicago
Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., Kiechle, M., Schmitt, M."Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells". Oncology Letters 13, no. 6 (2017): 4224-4230. https://doi.org/10.3892/ol.2017.5994
Copy and paste a formatted citation
x
Spandidos Publications style
Bronger H, Karge A, Dreyer T, Zech D, Kraeft S, Avril S, Kiechle M and Schmitt M: Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncol Lett 13: 4224-4230, 2017.
APA
Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S. ... Schmitt, M. (2017). Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells. Oncology Letters, 13, 4224-4230. https://doi.org/10.3892/ol.2017.5994
MLA
Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., Kiechle, M., Schmitt, M."Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells". Oncology Letters 13.6 (2017): 4224-4230.
Chicago
Bronger, H., Karge, A., Dreyer, T., Zech, D., Kraeft, S., Avril, S., Kiechle, M., Schmitt, M."Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells". Oncology Letters 13, no. 6 (2017): 4224-4230. https://doi.org/10.3892/ol.2017.5994
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