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Article

Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons

  • Authors:
    • Mitsunori Higuchi
    • Hironori Takagi
    • Yuki Owada
    • Takuya Inoue
    • Yuzuru Watanabe
    • Takumi Yamaura
    • Mitsuro Fukuhara
    • Satoshi Muto
    • Naoyuki Okabe
    • Yuki Matsumura
    • Takeo Hasegawa
    • Atsushi Yonechi
    • Jun Osugi
    • Mika Hoshino
    • Yutaka Shio
    • Koichi Fujiu
    • Ryuzo Kanno
    • Akio Ohishi
    • Hiroyuki Suzuki
    • Mitsukazu Gotoh
  • View Affiliations / Copyright

    Affiliations: Department of Chest Surgery, Division of Surgery, Fukushima Medical University School of Medicine, Fukushima 960‑1295, Japan, Department of Thoracic Surgery, Shirakawa Kosei General Hospital, Shirakawa, Fukushima 961‑0005, Japan, Department of Thoracic Surgery, Takeda General Hospital, Aizuwakamatsu, Fukushima 965‑8585, Japan, Department of Surgery, Fukushima Rosai Hospital, Iwaki, Fukushima 973‑8403, Japan, Department of Thoracic Surgery, Southern Tohoku General Hospital, Koriyama, Fukushima 963‑8563, Japan, Department of Thoracic Surgery, Fukushima Red Cross Hospital, Fukushima 960‑8530, Japan
  • Pages: 4315-4321
    |
    Published online on: April 5, 2017
       https://doi.org/10.3892/ol.2017.5998
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Abstract

The present retrospective multi-center study aimed to evaluate the efficacy and feasibility of nanoparticle albumin-bound (nab)-paclitaxel plus carboplatin as a second or late‑phase chemotherapy in patients with non‑small cell lung cancer (NSCLC). A total of 25 patients with recurrent or advanced NSCLC who had received previous chemotherapy were treated with nab‑paclitaxel (70‑100 mg/m2, intravenously) on days 1, 8 and 15 every 28 days with a carboplatin area under the concentration‑time curve of 4‑6 on day 1. The overall response rate, disease control rate, progression‑free survival (PFS), overall survival (OS) and toxicities were statistically evaluated. Of the 25 patients, there were 9 cases of recurrent disease following surgery, 16 cases of advanced disease, 13 cases of adenocarcinoma, 11 cases of squamous cell carcinoma and 1 case of large cell carcinoma. A total of 13 patients received second‑line chemotherapy and 12 received fourth‑line or later chemotherapy. One patient exhibited a complete response, 7 had a partial response, 10 exhibited stable disease and 7 had progressive disease. The overall response rate was 32.0% and the disease control rate was 72.0%. The median PFS and median OS following nab‑paclitaxel treatment were 4.0 and 14.0 months, respectively. Frequent treatment‑associated adverse events were myelosuppression, peripheral neuropathy, gastrointestinal symptoms and baldness, the majority of which were grade 1‑2. Grade 3‑4 neutropenia, thrombocytopenia and anemia occurred in 7 (28.0%), 3 (12.0%) and 2 (8.0%) patients, respectively. No patients experienced grade 3‑4 sensory neuropathy and no grade 5 adverse effects were observed. Nab‑paclitaxel plus carboplatin as second‑phase or later chemotherapy provided a small but significant survival benefit for patients with recurrent or advanced NSCLC, with tolerable adverse effects. To the best of our knowledge, the results of the present study demonstrated for the first time that nab‑paclitaxel plus carboplatin is a promising and feasible late‑phase chemotherapeutic agent for NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Higuchi M, Takagi H, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Muto S, Okabe N, Matsumura Y, Matsumura Y, et al: Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons. Oncol Lett 13: 4315-4321, 2017.
APA
Higuchi, M., Takagi, H., Owada, Y., Inoue, T., Watanabe, Y., Yamaura, T. ... Gotoh, M. (2017). Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons. Oncology Letters, 13, 4315-4321. https://doi.org/10.3892/ol.2017.5998
MLA
Higuchi, M., Takagi, H., Owada, Y., Inoue, T., Watanabe, Y., Yamaura, T., Fukuhara, M., Muto, S., Okabe, N., Matsumura, Y., Hasegawa, T., Yonechi, A., Osugi, J., Hoshino, M., Shio, Y., Fujiu, K., Kanno, R., Ohishi, A., Suzuki, H., Gotoh, M."Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons". Oncology Letters 13.6 (2017): 4315-4321.
Chicago
Higuchi, M., Takagi, H., Owada, Y., Inoue, T., Watanabe, Y., Yamaura, T., Fukuhara, M., Muto, S., Okabe, N., Matsumura, Y., Hasegawa, T., Yonechi, A., Osugi, J., Hoshino, M., Shio, Y., Fujiu, K., Kanno, R., Ohishi, A., Suzuki, H., Gotoh, M."Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons". Oncology Letters 13, no. 6 (2017): 4315-4321. https://doi.org/10.3892/ol.2017.5998
Copy and paste a formatted citation
x
Spandidos Publications style
Higuchi M, Takagi H, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Muto S, Okabe N, Matsumura Y, Matsumura Y, et al: Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons. Oncol Lett 13: 4315-4321, 2017.
APA
Higuchi, M., Takagi, H., Owada, Y., Inoue, T., Watanabe, Y., Yamaura, T. ... Gotoh, M. (2017). Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons. Oncology Letters, 13, 4315-4321. https://doi.org/10.3892/ol.2017.5998
MLA
Higuchi, M., Takagi, H., Owada, Y., Inoue, T., Watanabe, Y., Yamaura, T., Fukuhara, M., Muto, S., Okabe, N., Matsumura, Y., Hasegawa, T., Yonechi, A., Osugi, J., Hoshino, M., Shio, Y., Fujiu, K., Kanno, R., Ohishi, A., Suzuki, H., Gotoh, M."Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons". Oncology Letters 13.6 (2017): 4315-4321.
Chicago
Higuchi, M., Takagi, H., Owada, Y., Inoue, T., Watanabe, Y., Yamaura, T., Fukuhara, M., Muto, S., Okabe, N., Matsumura, Y., Hasegawa, T., Yonechi, A., Osugi, J., Hoshino, M., Shio, Y., Fujiu, K., Kanno, R., Ohishi, A., Suzuki, H., Gotoh, M."Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons". Oncology Letters 13, no. 6 (2017): 4315-4321. https://doi.org/10.3892/ol.2017.5998
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