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Article Open Access

DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma

  • Authors:
    • Yi Cao
    • Ruisheng Ke
    • Shaohu Wang
    • Xu Zhu
    • Jianwei Chen
    • Chao Huang
    • Yi Jiang
    • Lizhi Lv
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Fuzhou General Hospital, Fuzhou, Fujian 350025, P.R. China
    Copyright: © Cao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4109-4116
    |
    Published online on: April 6, 2017
       https://doi.org/10.3892/ol.2017.5999
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Abstract

The present study was designed to determine the significance of DNA topoisomerase IIa (TopoIIα) and Ki67 in hepatocellular carcinoma cells (HCCs). The present study included 353 patients with HCC. The association of clinicopathological data with the expression of TopoIIα and Ki67 by immunohistochemistry was analyzed by χ2 test. Cox multivariate proportional hazards regression analysis and Kaplan‑Meier analysis were performed with all the variables to derive risk estimates associated with overall survival (OS)/recurrence‑free survival (RFS) and to control for confounders. TopoIIα and Ki67 were detected in the nuclei of the tumor cells. With TopoIIα, 35.7% of cells exhibited high expression, which was associated with tumor‑node‑metastasis stage, tumor size and α‑fetoprotein level. With Ki67, 37.1% of cells exhibited high expression, which was associated with tumor‑node‑metastasis stage, tumor size and α-fetoprotein level. Correlation was identified between the expression level of TopoIIα and Ki67 in HCCs (r=0.444). Multivariate analysis revealed that high TopoIIα expression is a prognostic indicator for RFS [hazard ratio (HR), 2.002; 95% confidence interval (CI), 1.429‑2.806] and OS (HR, 2.749; 95% CI, 1.919‑3.939), and high Ki67 expression is a prognostic indicator for OS (HR, 1.816; 95% CI, 1.273‑2.589). The TopoIIα‑low group had a significantly increased RFS rate (55.6 vs. 31.7%) and OS rate (66.5 vs. 23.8%) compared with the TopoIIα‑high group. The OS rate was increased in the Ki67‑low group compared with the Ki67‑high group (67.0 vs. 26.5%). Expression of TopoIIα and Ki67 are independent prognostic factors for survival in HCCs. TopoIIα was positively associated with Ki67 expression.
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1 

Kew MC: Hepatocellular carcinoma: Epidemiology and risk factors. J Hepatocell Carcinoma. 1:115–125. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Tanaka S and Arii S: Molecular targeted therapies in hepatocellular carcinoma. Semin Oncol. 39:486–492. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Olsen SK, Brown RS and Siegel AB: Hepatocellular carcinoma: Review of current treatment with a focus on targeted molecular therapies. Therap Adv Gastroenterol. 3:55–66. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Furihata T, Sawada T, Kita J, Iso Y, Kato M, Rokkaku K, Shimoda M and Kubota K: Serum alpha-fetoprotein level per tumor volume reflects prognosis in patients with hepatocellular carcinoma after curative hepatectomy. Hepatogastroenterology. 55:1705–1709. 2008.PubMed/NCBI

6 

Bhattacharya S, Steele R, Shrivastava S, Chakraborty S, Di Bisceglie AM and Ray RB: Serum miR-30e and miR-223 as novel noninvasive biomarkers for hepatocellular carcinoma. Am J Pathol. 186:242–247. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Cubeddu A, Astara G, Madeddu C, Ruggiero V, Cabula C, Serra G, Ganga R, Faloppi L, Cascinu S and Scartozzi M: L47Osteopontin (OPN) and interleukin-6 (IL-6) as predictive biomarkers in HCC receiving loco-regional treatment: Preliminary results. Ann Oncol. 26:(Suppl 6). vi.124–vi. 2015. View Article : Google Scholar

8 

Xu B, Cai Z, Zeng Y, Chen L, Du X, Huang A, Liu X and Liu J: α-Methylacyl-CoA racemase (AMACR) serves as a prognostic biomarker for the early recurrence/metastasis of HCC. J Clin Pathol. 67:974–979. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Watt PM and Hickson ID: Structure and function of type II DNA topoisomerases. Biochem J. 303:681–695. 1994. View Article : Google Scholar : PubMed/NCBI

10 

Forterre P, Gribaldo S, Gadelle D and Serre MC: Origin and evolution of DNA topoisomerases. Biochimie. 89:427–446. 2007. View Article : Google Scholar : PubMed/NCBI

11 

McClendon AK and Osheroff N: DNA topoisomerase II, genotoxicity, and cancer. Mutat Res. 623:83–97. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Xu XL, Zheng WH, Fu ZX, Li ZP, Xie HX, Li XX, Jiang LH, Wang Y, Zhu SM and Mao WM: Topo2A as a prognostic biomarker for patients with resectable esophageal squamous cell carcinomas. Med Oncol. 32:3962015. View Article : Google Scholar : PubMed/NCBI

13 

Parker AS, Eckel-Passow JE, Serie D, Hilton T, Parasramka M, Joseph RW, Wu KJ, Cheville JC and Leibovich BC: Increased expression of topoisomerase II alpha is an independent marker of increased risk of cancer-specific death in patients with clear cell renal cell carcinoma. Eur Urol. 66:929–935. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Mrklić I, Pogorelić Z, Ćapkun V and Tomić S: Expression of topoisomerase II-α in triple negative breast cancer. Appl Immunohistochem Mol Morphol. 22:182–187. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Lan J, Huang HY, Lee SW, Chen TJ, Tai HC, Hsu HP, Chang KY and Li CF: TOP2A overexpression as a poor prognostic factor in patients with nasopharyngeal carcinoma. Tumour Biol. 35:179–187. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Scholzen T and Gerdes J: The Ki-67 protein: From the known and the unknown. J Cell Physiol. 182:311–322. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Mahmoud AM, Macias V, Al-alem U, Kresovich JK, Khramtsova G, Kajdacsy-Balla A, Wiley EL and Rauscher GH: Ki67 is an independent prognostic marker in breast cancer even after accounting for molecular subtype. Cancer Res. 74:55692014. View Article : Google Scholar

18 

Kee KM, Wang JH, Lee CM, Chen CL, Changchien CS, Hu TH, Cheng YF, Hsu HC, Wang CC, Chen TY, et al: Validation of clinical AJCC/UICC TNM staging system for hepatocellular carcinoma: Analysis of 5,613 cases from a medical center in southern Taiwan. Int J Cancer. 120:2650–2655. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Schmilovitz-Weiss H, Tobar A, Halpern M, Levy I, Shabtai E and Ben-Ari Z: Tissue expression of squamous cellular carcinoma antigen and Ki67 in hepatocellular carcinoma-correlation with prognosis: A historical prospective study. Diagn Pathol. 6:1212011. View Article : Google Scholar : PubMed/NCBI

20 

Li WQ, Park Y, McGlynn KA, Hollenbeck AR, Taylor PR, Goldstein AM and Freedman ND: Index-based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study. Hepatology. 60:588–597. 2014. View Article : Google Scholar : PubMed/NCBI

21 

El-Serag HB: Hepatocellular carcinoma. N Engl J Med. 365:1118–1127. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Qin LX and Tang ZY: Recent progress in predictive biomarkers for metastatic recurrence of human hepatocellular carcinoma: A review of the literature. J Cancer Res Clin Oncol. 130:497–513. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Chiloiro S, Bianchi A, Doglietto F, de Waure C, Giampietro A, Fusco A, Iacovazzo D, Tartaglione L, Di Nardo F, Signorelli F, et al: Radically resected pituitary adenomas: Prognostic role of Ki 67 labeling index in a monocentric retrospective series and literature review. Pituitary. 17:267–276. 2014.PubMed/NCBI

24 

Rademakers SE, Hoogsteen IJ, Rijken PF, Terhaard CH, Doornaert PA, Langendijk JA, van den Ende P, van der Kogel AJ, Bussink J and Kaanders JH: Prognostic value of the proliferation marker Ki-67 in laryngeal carcinoma: Results of the accelerated radiotherapy with carbogen breathing and nicotinamide phase III randomized trial. Head Neck. 37:171–176. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Beuschlein F, Weigel J, Saeger W, Kroiss M, Wild V, Daffara F, Libé R, Ardito A, Al Ghuzlan A, Quinkler M, et al: Major prognostic role of Ki67 in localized adrenocortical carcinoma after complete resection. J Clin Endocrinol Metab. 100:841–849. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Battista MJ, Mantai N, Sicking I, Cotarelo C, Weyer V, Lebrecht A, Solbach C and Schmidt M: Ki-67 as an independent prognostic factor in an unselected cohort of patients with ovarian cancer: Results of an explorative, retrospective study. Oncol Rep. 31:2213–2219. 2014.PubMed/NCBI

27 

He X, Chen Z, Fu T, Jin X, Yu T, Liang Y, Zhao X and Huang L: Ki-67 is a valuable prognostic predictor of lymphoma but its utility varies in lymphoma subtypes: Evidence from a systematic meta-analysis. BMC Cancer. 14:1532014. View Article : Google Scholar : PubMed/NCBI

28 

Luo Y, Ren F, Liu Y, Shi Z, Tan Z, Xiong H, Dang Y and Chen G: Clinicopathological and prognostic significance of high Ki-67 labeling index in hepatocellular carcinoma patients: A meta-analysis. Int J Clin Exp Med. 8:10235–10247. 2015.PubMed/NCBI

29 

Coss A, Tosetto M, Fox EJ, Sapetto-Rebow B, Gorman S, Kennedy BN, Lloyd AT, Hyland JM, O'Donoghue DP, Sheahan K, et al: Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis. Cancer Lett. 276:228–238. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Bidgoli SA, Azizi E and Zavarhei MD: Association between p53 expression and Bcl-2, P-glycoprotein, topoisomerase II alpha, thymidylate synthase and thymidine phosphorylase as potential therapeutic targets in colorectal cancer patients. Pak J Biol Sci. 10:3350–3355. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Shvero J, Koren R, Shvili I, Yaniv E, Sadov R and Hadar T: Expression of human DNA topoisomerase II-alpha in squamous cell carcinoma of the larynx and its correlation with clinicopathologic variables. Am J Clin Pathol. 130:934–849. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Kim EJ, Lee YS, Kim YJ, Kim MJ, Ha YS, Jeong P, Lee OJ and Kim WJ: Clinical implications and prognostic values of topoisomerase-II alpha expression in primary non-muscle-invasive bladder cancer. Urology. 75:1516.e9–e13. 2010. View Article : Google Scholar

33 

Ali Y and Hamid Abd S: Human topoisomerase II alpha as a prognostic biomarker in cancer chemotherapy. Tumour Biol. 37:47–55. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Wong N, Yeo W, Wong WL, Wong NL, Chan KY, Mo FK, Koh J, Chan SL, Chan AT, Lai PB, et al: TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance. Int J Cancer. 124:644–652. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Watanuki A, Ohwada S, Fukusato T, Makita F, Yamada T, Kikuchi A and Morishita Y: Prognostic significance of DNA topoisomerase IIalpha expression in human hepatocellular carcinoma. Anticancer Res. 22:1113–1119. 2002.PubMed/NCBI

36 

Panvichian R, Tantiwetrueangdet A, Angkathunyakul N and Leelaudomlipi S: TOP2A amplification and overexpression in hepatocellular carcinoma tissues. Biomed Res Int. 2015:3816022015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cao Y, Ke R, Wang S, Zhu X, Chen J, Huang C, Jiang Y and Lv L: DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma. Oncol Lett 13: 4109-4116, 2017.
APA
Cao, Y., Ke, R., Wang, S., Zhu, X., Chen, J., Huang, C. ... Lv, L. (2017). DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma. Oncology Letters, 13, 4109-4116. https://doi.org/10.3892/ol.2017.5999
MLA
Cao, Y., Ke, R., Wang, S., Zhu, X., Chen, J., Huang, C., Jiang, Y., Lv, L."DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma". Oncology Letters 13.6 (2017): 4109-4116.
Chicago
Cao, Y., Ke, R., Wang, S., Zhu, X., Chen, J., Huang, C., Jiang, Y., Lv, L."DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma". Oncology Letters 13, no. 6 (2017): 4109-4116. https://doi.org/10.3892/ol.2017.5999
Copy and paste a formatted citation
x
Spandidos Publications style
Cao Y, Ke R, Wang S, Zhu X, Chen J, Huang C, Jiang Y and Lv L: DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma. Oncol Lett 13: 4109-4116, 2017.
APA
Cao, Y., Ke, R., Wang, S., Zhu, X., Chen, J., Huang, C. ... Lv, L. (2017). DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma. Oncology Letters, 13, 4109-4116. https://doi.org/10.3892/ol.2017.5999
MLA
Cao, Y., Ke, R., Wang, S., Zhu, X., Chen, J., Huang, C., Jiang, Y., Lv, L."DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma". Oncology Letters 13.6 (2017): 4109-4116.
Chicago
Cao, Y., Ke, R., Wang, S., Zhu, X., Chen, J., Huang, C., Jiang, Y., Lv, L."DNA topoisomerase IIα and Ki67 are prognostic factors in patients with hepatocellular carcinoma". Oncology Letters 13, no. 6 (2017): 4109-4116. https://doi.org/10.3892/ol.2017.5999
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