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Age-associated prognostic and predictive biomarkers in patients with breast cancer

  • Authors:
    • Markéta Kolečková
    • Zdeněk Kolář
    • Jiří Ehrmann
    • Gabriela Kořínková
    • Radek Trojanec
  • View Affiliations / Copyright

    Affiliations: Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University, CZ‑775 15 Olomouc, Czech Republic, Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, CZ‑775 15 Olomouc, Czech Republic
    Copyright: © Kolečková et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4201-4207
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    Published online on: April 6, 2017
       https://doi.org/10.3892/ol.2017.6000
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Abstract

To date, no comprehensive prognostic or predictive marker profiling analysis has been performed in association with the age of patients with breast cancer. In the present study, 632 breast cancer tissue samples were analyzed for expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), B‑cell lymphoma (Bcl)-2 protein, HER2 gene amplification, proliferation [as evaluated by proliferating cell nuclear antigen (PCNA) and Ki‑67 index], tumor grade, histological type and molecular subtype. The data revealed correlations with the age of patients. A statistically significant positive correlation was identified between patient age and expression of ER (P<0.0001). There was no significant association between patient age and PR, HER2 protein expression, HER2 gene amplification or PCNA. A significant negative correlation between age and Ki‑67 expression (P<0.0001) as well as grade of tumor (P=0.007) was identified. The spectrum of molecular subtypes differed according to age (P=0.0003). The highest incidence of aggressive triple‑negative and HER2‑positive breast cancer was present in patients aged between 20 and 39 years. Luminal A subtype was the most frequent cancer subtype in patients from age 40 onwards, where proliferation activity declined with age and expression of hormone receptors increased along with Bcl‑2 expression. Aggressive forms of breast cancer were more common in younger patients. Prognostic and predictive markers have a complex age‑specific distribution. The findings of less aggressive luminal A and B subtypes in older patients, and the positive correlation with ER, PR and Bcl‑2 expression reveal the potential efficacy of Bcl‑2 as a marker of hormone responsiveness in these patients.
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Copy and paste a formatted citation
Spandidos Publications style
Kolečková M, Kolář Z, Ehrmann J, Kořínková G and Trojanec R: Age-associated prognostic and predictive biomarkers in patients with breast cancer. Oncol Lett 13: 4201-4207, 2017.
APA
Kolečková, M., Kolář, Z., Ehrmann, J., Kořínková, G., & Trojanec, R. (2017). Age-associated prognostic and predictive biomarkers in patients with breast cancer. Oncology Letters, 13, 4201-4207. https://doi.org/10.3892/ol.2017.6000
MLA
Kolečková, M., Kolář, Z., Ehrmann, J., Kořínková, G., Trojanec, R."Age-associated prognostic and predictive biomarkers in patients with breast cancer". Oncology Letters 13.6 (2017): 4201-4207.
Chicago
Kolečková, M., Kolář, Z., Ehrmann, J., Kořínková, G., Trojanec, R."Age-associated prognostic and predictive biomarkers in patients with breast cancer". Oncology Letters 13, no. 6 (2017): 4201-4207. https://doi.org/10.3892/ol.2017.6000
Copy and paste a formatted citation
x
Spandidos Publications style
Kolečková M, Kolář Z, Ehrmann J, Kořínková G and Trojanec R: Age-associated prognostic and predictive biomarkers in patients with breast cancer. Oncol Lett 13: 4201-4207, 2017.
APA
Kolečková, M., Kolář, Z., Ehrmann, J., Kořínková, G., & Trojanec, R. (2017). Age-associated prognostic and predictive biomarkers in patients with breast cancer. Oncology Letters, 13, 4201-4207. https://doi.org/10.3892/ol.2017.6000
MLA
Kolečková, M., Kolář, Z., Ehrmann, J., Kořínková, G., Trojanec, R."Age-associated prognostic and predictive biomarkers in patients with breast cancer". Oncology Letters 13.6 (2017): 4201-4207.
Chicago
Kolečková, M., Kolář, Z., Ehrmann, J., Kořínková, G., Trojanec, R."Age-associated prognostic and predictive biomarkers in patients with breast cancer". Oncology Letters 13, no. 6 (2017): 4201-4207. https://doi.org/10.3892/ol.2017.6000
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