B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma

  • Authors:
    • Wei Wang
    • Huai‑Jun Ji
    • Ning‑Bo Sun
    • Xiao‑Tian Chang
    • Bing Xu
    • Yao Wang
    • Ming Cao
    • Qiang Zhu
    • Qi Zang
    • Zhong‑Min Jiang
  • View Affiliations

  • Published online on: April 6, 2017     https://doi.org/10.3892/ol.2017.6001
  • Pages: 4349-4356
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Abstract

High expression of B-cell specific Moloney leukemia virus insert site 1 (Bmi‑1) and peptidyl arginine deiminase IV (PADI4) is associated with esophageal carcinoma. However, few studies have investigated the association between the Bmi-1 and PADI4 genes. The aim of the present study was to evaluate the expression of Bmi‑1 and PADI4 and identify the association between the Bmi‑1 and PADI4 genes in esophageal squamous cell carcinoma (ESCC) tissues. Bmi‑1 and PADI4 gene expression levels were measured using immunohistochemistry, western blotting and reverse transcription‑quantitative polymerase chain reaction in ESCC tissues from 86 patients who had not received pre‑operative chemoradiation. The results revealed that the Bmi‑1 and PADI4 genes had increased expression in carcinoma tissues compared with pericarcinous tissue (P<0.05). Bmi‑1 gene expression was revealed to be associated with differentiation degree, clinical stage and lymph node metastasis (P<0.05), but had no association with gender, age or depth of invasion (P>0.05). The expression of PADI4 was associated with clinical stage, depth of invasion and lymph node metastasis (P<0.05), but was not associated with gender, age or differentiation degree (P>0.05). In addition, there was a positive association between Bmi‑1 and PADI4 gene expression in ESCC (P<0.05). These results indicated that Bmi‑1 and PADI4 positively regulate carcinogenesis and progression of ESCC.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang W, Ji HJ, Sun NB, Chang XT, Xu B, Wang Y, Cao M, Zhu Q, Zang Q, Jiang ZM, Jiang ZM, et al: B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma. Oncol Lett 13: 4349-4356, 2017
APA
Wang, W., Ji, H., Sun, N., Chang, X., Xu, B., Wang, Y. ... Jiang, Z. (2017). B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma. Oncology Letters, 13, 4349-4356. https://doi.org/10.3892/ol.2017.6001
MLA
Wang, W., Ji, H., Sun, N., Chang, X., Xu, B., Wang, Y., Cao, M., Zhu, Q., Zang, Q., Jiang, Z."B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma". Oncology Letters 13.6 (2017): 4349-4356.
Chicago
Wang, W., Ji, H., Sun, N., Chang, X., Xu, B., Wang, Y., Cao, M., Zhu, Q., Zang, Q., Jiang, Z."B-cell specific Moloney leukemia virus insert site 1 and peptidyl arginine deiminase IV positively regulate carcinogenesis and progression of esophageal squamous cell carcinoma". Oncology Letters 13, no. 6 (2017): 4349-4356. https://doi.org/10.3892/ol.2017.6001