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Article

lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma

  • Authors:
    • Guo‑Hui Nie
    • Zhao Li
    • Hong‑Fang Duan
    • Liang Luo
    • Hong‑Yi Hu
    • Wei‑Qiang Yang
    • Li‑Ping Nie
    • Ru‑Fei Zhu
    • Xiao‑Fan Chen
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China, Department of Otolaryngology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Department of Otolaryngology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R. China, Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Biomedical Research Institute, Shenzhen Peking University‑The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, P.R. China
  • Pages: 4487-4492
    |
    Published online on: April 11, 2017
       https://doi.org/10.3892/ol.2017.6021
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Abstract

The mechanism of nasopharyngeal carcinoma (NPC) remains unclear. The present study investigated the abnormal expression of long non-coding (lnc)RNAs in NPC tissues and one NPC cell line to identify the involvement of lncRNAs in the tumorigenesis of NPC. Using a quantitative reverse transcription polymerase chain reaction (RT‑qPCR), the expression of lncRNA C22orf32-1 in NPC tissues and an NPC cell line was verified. The effects of lncRNA C22orf32‑1 on NPC cells were investigated with a cell proliferation assay, cell scratch assay, Transwell assay and a cell apoptosis assay. The expression levels of lncRNA C22orf32‑1 in NPC tissues and an NPC cell line were upregulated. lncRNA C22orf32‑1 promoted the proliferation, migration and invasion of NPC cells, and reduced the apoptosis of NPC cells. The data demonstrated that lncRNA C22orf32‑1 may facilitate the tumorigenesis of NPC, and may be used for the early diagnosis and treatment of NPC.
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Copy and paste a formatted citation
Spandidos Publications style
Nie GH, Li Z, Duan HF, Luo L, Hu HY, Yang WQ, Nie LP, Zhu RF, Chen XF, Zhang W, Zhang W, et al: lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma. Oncol Lett 13: 4487-4492, 2017.
APA
Nie, G., Li, Z., Duan, H., Luo, L., Hu, H., Yang, W. ... Zhang, W. (2017). lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma. Oncology Letters, 13, 4487-4492. https://doi.org/10.3892/ol.2017.6021
MLA
Nie, G., Li, Z., Duan, H., Luo, L., Hu, H., Yang, W., Nie, L., Zhu, R., Chen, X., Zhang, W."lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma". Oncology Letters 13.6 (2017): 4487-4492.
Chicago
Nie, G., Li, Z., Duan, H., Luo, L., Hu, H., Yang, W., Nie, L., Zhu, R., Chen, X., Zhang, W."lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma". Oncology Letters 13, no. 6 (2017): 4487-4492. https://doi.org/10.3892/ol.2017.6021
Copy and paste a formatted citation
x
Spandidos Publications style
Nie GH, Li Z, Duan HF, Luo L, Hu HY, Yang WQ, Nie LP, Zhu RF, Chen XF, Zhang W, Zhang W, et al: lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma. Oncol Lett 13: 4487-4492, 2017.
APA
Nie, G., Li, Z., Duan, H., Luo, L., Hu, H., Yang, W. ... Zhang, W. (2017). lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma. Oncology Letters, 13, 4487-4492. https://doi.org/10.3892/ol.2017.6021
MLA
Nie, G., Li, Z., Duan, H., Luo, L., Hu, H., Yang, W., Nie, L., Zhu, R., Chen, X., Zhang, W."lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma". Oncology Letters 13.6 (2017): 4487-4492.
Chicago
Nie, G., Li, Z., Duan, H., Luo, L., Hu, H., Yang, W., Nie, L., Zhu, R., Chen, X., Zhang, W."lncRNA C22orf32-1 contributes to the tumorigenesis of nasopharyngeal carcinoma". Oncology Letters 13, no. 6 (2017): 4487-4492. https://doi.org/10.3892/ol.2017.6021
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