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A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma

  • Authors:
    • Sha‑Sha Fan
    • Chu‑Shu Liao
    • You‑De Cao
    • Pei‑Ling Xiao
    • Tan Deng
    • Rong‑Cheng Luo
    • Hua‑Xin Duan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, P.R. China, Blood Disease Laboratory, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, P.R. China, Medical Clinical Laboratory, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan 410005, P.R. China, Department of Oncology, Traditional Chinese Medicine‑Integrated Hospital, Southern Medical University, Guangzhou, Guangdong 510315, P.R. China
    Copyright: © Fan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4208-4214
    |
    Published online on: April 11, 2017
       https://doi.org/10.3892/ol.2017.6024
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Abstract

The present study aimed to evaluate the diagnostic and prognostic value of Tat‑interacting protein 30 (HTATIP2/TIP30) levels alone and in combination with α-fetoprotein (AFP) for the evaluation of hepatocellular carcinoma (HCC) patients. ELISA and immunohistochemical measurements on the serum and tissue of HTATIP2/TIP30 protein from HCC patients and normal controls were made. Receiver operating characteristic (ROC) curve analyses of AFP and HTATIP2/TIP30 were performed, as well as logistic regression analysis of APF combined with HTATIP2/TIP30. Log‑rank analysis was used to correlate the prognosis with various levels of HTATIP2/TIP30. HTATIP2/TIP30 levels were significantly lower in the HCC group compared with the control group (4.50±2.63 vs. 9.50±2.04 ng/ml, P<0.001). ROC analysis revealed an optimal cut‑off point at 7.27 ng/ml HTATIP2/TIP30 for separating the HCC from the control groups. The sensitivity and specificity were 84.6 and 93.7% (P<0.001), respectively. ROC areas of HTATIP2/TIP30 (0.928, P<0.001) were significantly higher than those for AFP (P<0.001). The area under the curve of the HTATIP2/TIP30 and AFP combination was 0.950 (P<0.001). Log‑rank tests revealed that the recurrence‑free survival time of the group with HTATIP2/TIP30>5.71 ng/ml was significantly higher than that of the control group (P<0.001). This is the first study to demonstrate that HTATIP2/TIP30 levels in serum may be an effective biomarker for the diagnosis and prognosis of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Fan SS, Liao CS, Cao YD, Xiao PL, Deng T, Luo RC and Duan HX: A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma. Oncol Lett 13: 4208-4214, 2017.
APA
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., & Duan, H. (2017). A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma. Oncology Letters, 13, 4208-4214. https://doi.org/10.3892/ol.2017.6024
MLA
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., Duan, H."A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma". Oncology Letters 13.6 (2017): 4208-4214.
Chicago
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., Duan, H."A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma". Oncology Letters 13, no. 6 (2017): 4208-4214. https://doi.org/10.3892/ol.2017.6024
Copy and paste a formatted citation
x
Spandidos Publications style
Fan SS, Liao CS, Cao YD, Xiao PL, Deng T, Luo RC and Duan HX: A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma. Oncol Lett 13: 4208-4214, 2017.
APA
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., & Duan, H. (2017). A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma. Oncology Letters, 13, 4208-4214. https://doi.org/10.3892/ol.2017.6024
MLA
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., Duan, H."A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma". Oncology Letters 13.6 (2017): 4208-4214.
Chicago
Fan, S., Liao, C., Cao, Y., Xiao, P., Deng, T., Luo, R., Duan, H."A low serum Tat-interacting protein 30 level is a diagnostic and prognostic biomarker for hepatocellular carcinoma". Oncology Letters 13, no. 6 (2017): 4208-4214. https://doi.org/10.3892/ol.2017.6024
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