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Case Report

Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report

  • Authors:
    • Maria Celeste Palmarocchi
    • Ruben Carlo Balzarotti Canger
    • Piercarlo Saletti
  • View Affiliations / Copyright

    Affiliations: Medical Oncology, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland, Department of Surgery, Lugano Regional Hospital, 6900 Lugano, Switzerland
  • Pages: 4445-4452
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    Published online on: April 11, 2017
       https://doi.org/10.3892/ol.2017.6026
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Abstract

Pancreatic cancer is the fourth leading cause of cancer mortality and is associated with a poor overall survival even when diagnosed early and considered resectable. Complete surgical removal with negative histological margins is an independent predictor of survival and remains the only potential curative treatment. In borderline resectable pancreatic adenocarcinoma (BRPAC), preoperative systemic therapy may increase resectability and margin‑negative resection rate. There is no current consensus on the optimal chemotherapy regimen for BRPAC. The present case describes a patient with BRPAC who achieved a pathological complete response to neoadjuvant FOLFIRINOX (folinic acid, fluorouracil, irinotecan and oxaliplatin), but early relapse following a pancreaticoduodenectomy without vascular resection, with an uneventful postoperative course, except for a pulmonary embolism.
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Copy and paste a formatted citation
Spandidos Publications style
Palmarocchi MC, Balzarotti Canger RC and Saletti P: Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report. Oncol Lett 13: 4445-4452, 2017.
APA
Palmarocchi, M.C., Balzarotti Canger, R.C., & Saletti, P. (2017). Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report. Oncology Letters, 13, 4445-4452. https://doi.org/10.3892/ol.2017.6026
MLA
Palmarocchi, M. C., Balzarotti Canger, R. C., Saletti, P."Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report". Oncology Letters 13.6 (2017): 4445-4452.
Chicago
Palmarocchi, M. C., Balzarotti Canger, R. C., Saletti, P."Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report". Oncology Letters 13, no. 6 (2017): 4445-4452. https://doi.org/10.3892/ol.2017.6026
Copy and paste a formatted citation
x
Spandidos Publications style
Palmarocchi MC, Balzarotti Canger RC and Saletti P: Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report. Oncol Lett 13: 4445-4452, 2017.
APA
Palmarocchi, M.C., Balzarotti Canger, R.C., & Saletti, P. (2017). Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report. Oncology Letters, 13, 4445-4452. https://doi.org/10.3892/ol.2017.6026
MLA
Palmarocchi, M. C., Balzarotti Canger, R. C., Saletti, P."Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report". Oncology Letters 13.6 (2017): 4445-4452.
Chicago
Palmarocchi, M. C., Balzarotti Canger, R. C., Saletti, P."Neoadjuvant chemotherapy in borderline resectable pancreatic cancer: A case report". Oncology Letters 13, no. 6 (2017): 4445-4452. https://doi.org/10.3892/ol.2017.6026
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