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Review

Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review)

  • Authors:
    • Wanyeon Kim
    • Jihoon Kang
    • Sungmin Lee
    • Buhyun Youn
  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, Pusan National University, Busan 46241, Republic of Korea, Department of Integrated Biological Science, Pusan National University, Busan 46241, Republic of Korea
  • Pages: 4593-4601
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    Published online on: April 18, 2017
       https://doi.org/10.3892/ol.2017.6042
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Abstract

The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation‑induced damage. The potential for antioxidants to decrease normal tissue damage induced by radiation has been investigated in animal models for a number of decades. In attempts for radioprotection, certain synthetic chemicals are suggested as antioxidants and normal tissue protectors against radiation‑induced damage, but they have exhibited limitations in pharmacological application due to undesirable effects and high toxicities at clinical doses. The present review focuses on the radioprotective efficacy of traditional oriental medicines with the advantage of low toxicity at pharmacological doses and how such treatments may influence various harmful effects induced by radiation in vitro and in vivo. In addition, medicinal plants and their active constituents with biological activities that may be associated with alleviation of radiation‑induced damage through antioxidant, anti-inflammatory, wound healing and immunostimulatory properties are discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Kim W, Kang J, Lee S and Youn B: Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review). Oncol Lett 13: 4593-4601, 2017.
APA
Kim, W., Kang, J., Lee, S., & Youn, B. (2017). Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review). Oncology Letters, 13, 4593-4601. https://doi.org/10.3892/ol.2017.6042
MLA
Kim, W., Kang, J., Lee, S., Youn, B."Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review)". Oncology Letters 13.6 (2017): 4593-4601.
Chicago
Kim, W., Kang, J., Lee, S., Youn, B."Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review)". Oncology Letters 13, no. 6 (2017): 4593-4601. https://doi.org/10.3892/ol.2017.6042
Copy and paste a formatted citation
x
Spandidos Publications style
Kim W, Kang J, Lee S and Youn B: Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review). Oncol Lett 13: 4593-4601, 2017.
APA
Kim, W., Kang, J., Lee, S., & Youn, B. (2017). Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review). Oncology Letters, 13, 4593-4601. https://doi.org/10.3892/ol.2017.6042
MLA
Kim, W., Kang, J., Lee, S., Youn, B."Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review)". Oncology Letters 13.6 (2017): 4593-4601.
Chicago
Kim, W., Kang, J., Lee, S., Youn, B."Effects of traditional oriental medicines as anti-cytotoxic agents in radiotherapy (Review)". Oncology Letters 13, no. 6 (2017): 4593-4601. https://doi.org/10.3892/ol.2017.6042
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