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Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis

  • Authors:
    • Peng Chang
    • Xiangjun Wang
    • Ya Zhou
    • Yulong Hou
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic and Cardiac Surgery, Xuzhou Cancer Hospital, Xuzhou, Jiangsu 221005, P.R. China
    Copyright: © Chang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4691-4694
    |
    Published online on: April 19, 2017
       https://doi.org/10.3892/ol.2017.6047
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Abstract

The correlation between the expression level of microRNA (miR)-655 in esophageal cancer with proliferation, invasion and prognosis was investigated. Reverse transcription-quantitative polymerase chain reaction technique was used to detect the expression level of miR‑655 in esophageal cancer cell lines KYSE410 and EC9706, tumor tissues and normal cancer‑adjacent tissues of 63 cases of patients with esophageal squamous cell carcinoma (ESCC). The expression of miR‑655 was upregulated in ESCC cells through the transfection of miR‑655 mimics, and the influence of miR‑655 on proliferation and invasion ability of ESCC cells was observed. Combined with the clinical data, the correlation between the expression of miR‑655 and the prognosis of esophageal cancer was analyzed. The expression of miR‑655 was downregulated in 2 ESCC cell lines and 73.02% of ESCC tissues. The results showed that the increased expression of miR-655 via transfection of mimics inhibited the proliferation and invasion ability of ESCC cells. Combined with clinical data analysis, it was found that the low‑expression of miR‑655 was related to poorer progression‑free survival. In conclusion, the high‑expression of miR‑655 can inhibit the proliferation and invasion of ESCC, and plays a negative regulation role in the prognosis process of tumor patients. The targeted regulation of miR‑655 can be used as a new treatment method of ESCC.
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View References

1 

Mathé EA, Nguyen GH, Bowman ED, Zhao Y, Budhu A, Schetter AJ, Braun R, Reimers M, Kumamoto K, Hughes D, et al: MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: Associations with survival. Clin Cancer Res. 15:6192–6200. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Fareed KR, Kaye P, Soomro IN, Ilyas M, Martin S, Parsons SL and Madhusudan S: Biomarkers of response to therapy in oesophago-gastric cancer. Gut. 58:127–143. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Farazi TA, Spitzer JI, Morozov P and Tuschl T: miRNAs in human cancer. J Pathol. 223:102–115. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Rosenfeld N, Aharonov R, Meiri E, Rosenwald S, Spector Y, Zepeniuk M, Benjamin H, Shabes N, Tabak S, Levy A, et al: MicroRNAs accurately identify cancer tissue origin. Nat Biotechnol. 26:462–469. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Hobert O: Gene regulation by transcription factors and microRNAs. Science. 319:1785–1786. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Wang Y, Zang W, Du Y, Ma Y, Li M, Li P, Chen X, Wang T, Dong Z and Zhao G: Mir-655 up-regulation suppresses cell invasion by targeting pituitary tumor-transforming gene-1 in esophageal squamous cell carcinoma. J Transl Med. 11:3012013. View Article : Google Scholar : PubMed/NCBI

8 

Kitamura K, Seike M, Okano T, Matsuda K, Miyanaga A, Mizutani H, Noro R, Minegishi Y, Kubota K and Gemma A: MiR-134/487b/655 cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells. Mol Cancer Ther. 13:444–453. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Harazono Y, Muramatsu T, Endo H, Uzawa N, Kawano T, Harada K, Inazawa J and Kozaki K: miR-655 is an EMT-suppressive microRNA targeting ZEB1 and TGFBR2. PLoS One. 8:e627572013. View Article : Google Scholar : PubMed/NCBI

10 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Chen W, Zheng R, Zeng H, Zhang S and He J: Annual report on status of cancer in China, 2011. Chin J Cancer Res. 27:2–12. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, et al: Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA. 99:pp. 15524–15529. 2002; View Article : Google Scholar : PubMed/NCBI

13 

Pan X, Wang ZX and Wang R: MicroRNA-21: A novel therapeutic target in human cancer. Cancer Biol Ther. 10:1224–1232. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, Schwartz G, Wells W, Kauppinen S and Cole CN: Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer. Cancer Res. 67:11612–11620. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Medina PP, Nolde M and Slack FJ: OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature. 467:86–90. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Schaefer A, Jung M, Mollenkopf HJ, Wagner I, Stephan C, Jentzmik F, Miller K, Lein M, Kristiansen G and Jung K: Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma. Int J Cancer. 126:1166–1176. 2010.PubMed/NCBI

18 

Davis E, Caiment F, Tordoir X, Cavaillé J, Ferguson-Smith A, Cockett N, Georges M and Charlier C: RNAi-mediated allelic trans-interaction at the imprinted Rtl1/Peg11 locus. Curr Biol. 15:743–749. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Castilla MÁ, Moreno-Bueno G, Romero-Pérez L, Van De Vijver K, Biscuola M, López-García MÁ, Prat J, Matías-Guiu X, Cano A, Oliva E, et al: Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma. J Pathol. 223:72–80. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chang P, Wang X, Zhou Y and Hou Y: Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis. Oncol Lett 13: 4691-4694, 2017.
APA
Chang, P., Wang, X., Zhou, Y., & Hou, Y. (2017). Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis. Oncology Letters, 13, 4691-4694. https://doi.org/10.3892/ol.2017.6047
MLA
Chang, P., Wang, X., Zhou, Y., Hou, Y."Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis". Oncology Letters 13.6 (2017): 4691-4694.
Chicago
Chang, P., Wang, X., Zhou, Y., Hou, Y."Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis". Oncology Letters 13, no. 6 (2017): 4691-4694. https://doi.org/10.3892/ol.2017.6047
Copy and paste a formatted citation
x
Spandidos Publications style
Chang P, Wang X, Zhou Y and Hou Y: Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis. Oncol Lett 13: 4691-4694, 2017.
APA
Chang, P., Wang, X., Zhou, Y., & Hou, Y. (2017). Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis. Oncology Letters, 13, 4691-4694. https://doi.org/10.3892/ol.2017.6047
MLA
Chang, P., Wang, X., Zhou, Y., Hou, Y."Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis". Oncology Letters 13.6 (2017): 4691-4694.
Chicago
Chang, P., Wang, X., Zhou, Y., Hou, Y."Analysis of the correlation between the expression of miR-655 and esophageal cancer prognosis". Oncology Letters 13, no. 6 (2017): 4691-4694. https://doi.org/10.3892/ol.2017.6047
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