Open Access

E‑cadherin: A potential biomarker of colorectal cancer prognosis (Review)

  • Authors:
    • Niki Christou
    • Aurélie Perraud
    • Sabrina Blondy
    • Marie‑Odile Jauberteau
    • Serge Battu
    • Muriel Mathonnet
  • View Affiliations

  • Published online on: April 20, 2017     https://doi.org/10.3892/ol.2017.6063
  • Pages: 4571-4576
  • Copyright: © Christou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Colorectal cancer (CRC) is a common and lethal disease. It is the third most common type of cancer in the world, behind lung and breast cancer, with almost 1.4 million new cases diagnosed in 2012. The risk of developing CRC is influenced by environmental and genetic factors. Adenocarcinomas comprise the vast majority (98%) of CRCs. A patient’s likelihood of survival is associated with the tumor stage at the time of diagnosis. With regular screening, CRC can be identified early, when treatment is the most effective. However, CRC is typically asymptomatic until the advanced stages. The combination of the absence of symptoms and current screening methodology results in a significant number of patients being diagnosed in advanced stages. The purpose of the present review is to discuss and summarize the biomarkers linked to CRC progression, particularly the controversial E‑cadherin, which is a calcium‑dependent cell‑cell adhesion molecule involved in the mesenchymal‑epithelial transition.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Christou N, Perraud A, Blondy S, Jauberteau MO, Battu S and Mathonnet M: E‑cadherin: A potential biomarker of colorectal cancer prognosis (Review). Oncol Lett 13: 4571-4576, 2017
APA
Christou, N., Perraud, A., Blondy, S., Jauberteau, M., Battu, S., & Mathonnet, M. (2017). E‑cadherin: A potential biomarker of colorectal cancer prognosis (Review). Oncology Letters, 13, 4571-4576. https://doi.org/10.3892/ol.2017.6063
MLA
Christou, N., Perraud, A., Blondy, S., Jauberteau, M., Battu, S., Mathonnet, M."E‑cadherin: A potential biomarker of colorectal cancer prognosis (Review)". Oncology Letters 13.6 (2017): 4571-4576.
Chicago
Christou, N., Perraud, A., Blondy, S., Jauberteau, M., Battu, S., Mathonnet, M."E‑cadherin: A potential biomarker of colorectal cancer prognosis (Review)". Oncology Letters 13, no. 6 (2017): 4571-4576. https://doi.org/10.3892/ol.2017.6063