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Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function

  • Authors:
    • Ayako Ichikawa
    • Hiroaki Miyoshi
    • Fumiko Arakawa
    • Junichi Kiyasu
    • Kensaku Sato
    • Daisuke Niino
    • Yoshizo Kimura
    • Maki Yoshida
    • Riko Kawano
    • Hiroko Muta
    • Yasuo Sugita
    • Koichi Ohshima
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan, Biostatistics Center, School of Medicine, Kurume University, Kurume, Fukuoka 830 0011, Japan
    Copyright: © Ichikawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4611-4618
    |
    Published online on: April 21, 2017
       https://doi.org/10.3892/ol.2017.6067
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Abstract

Human T-cell lymphotropic virus type (HTLV)-1 Tax is a viral protein that has been reported to be important in the proliferation of adult T‑cell leukemia/lymphoma (ATLL) cells and to be a target of HTLV‑1‑specific cytotoxic T lymphocytes (CTLs). However, it is not clear how Tax‑specific CTLs behave in lymph nodes of ATLL patients. The present study analyzed the immunostaining of Tax‑specific CTLs. Furthermore, ATLL tumor cells are known to be positive for forkhead box P3 (Foxp3)and to have a regulatory T (Treg)‑cell‑like function. The association between T‑reg function and number and activity of Tax‑specific CTLs was also investigated. A total of 15 ATLL lymphoma cases with human leukocyte antigen (HLA)‑A24, for which Tax has a high affinity, were selected from the files of the Department of Pathology, School of Medicine, Kurume University (Kurume, Japan) using a polymerase chain reaction (PCR) method. Immunostaining was performed for cluster of differentiation (CD) 20, CD3, CD4, CD8, T-cell intracellular antigen‑1 and Foxp3 in paraffin sections, and for Tax, interferon γ and HLA‑A24 in frozen sections. In addition, the staining of Tax-specific CTLs (HLA‑A24‑restricted) was analyzed by MHC Dextramer® assay in frozen sections. In addition, the messenger RNA expression of Tax and HTLV‑1 basic leucine zipper factor were also evaluated by reverse transcription-PCR. Immunohistochemical staining of Tax protein in lymphoma tissue revealed the presence of positive lymphoma cells ranging from 5 to 80%, and immunohistochemical staining of HLA‑A24 revealed the presence of positive lymphoma cells ranging from 1 to 95%. The expression of Tax and HLA‑A24 was downregulated by viral function. Foxp3, a marker for Treg cells, was expressed in 0‑90% of cells. Several cases exhibited Tax‑specific CTL (HLA-A24-restricted)-positive cells, and there was an inverse correlation between Tax‑specific CTLs and Foxp3. However, neither Tax nor HLA-A24 expression was associated with CTL or Foxp3. Our study indicated the possibility that ATLL cells, which expressed Tax, target of CTL, evade the CTL‑mediated immune control by expression of Foxp3 as a Treg function.
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1 

Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD and Gallo RC: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci USA. 77:pp. 7415–7419. 1980; View Article : Google Scholar : PubMed/NCBI

2 

Verdonck K, González E, van Dooren S, Vandamme AM, Vanham G and Gotuzzo E: Human T-lymphotropic virus 1: Recent knowledge about an ancient infection. Lancet Infect Dis. 7:266–281. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Gessain A: Epidemiology of HTLV-1 and associated diseaseHuman T-cell Lymphotropic Virus Type-1. Hollsberg P and Hafler DA: Wiley; Chichister: pp. 33–64. 1996

4 

Tobinai K: Current management of adult T-cell leukemia/lymphoma. Oncology (Williston Park). 23:1250–1256. 2009.PubMed/NCBI

5 

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J and Vardiman JW: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 2. 4th. IARC Press; Lyon, France: 2008

6 

Karube K, Aoki R, Sugita Y, Yoshida S, Nomura Y, Shimizu K, Kimura Y, Hashikawa K, Takeshita M, Suzumiya J, et al: The relationship of Foxp3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma. Mod Pathol. 21:617–625. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Yano H, Ishida T, Inagaki A, Ishii T, Kusumoto S, Komatsu H, Iida S, Utsunomiya A and Ueda R: Regulatory T-cell function of adult T-cell leukemia/lymphoma cells. Int J Cancer. 120:2052–2057. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Marsh BJ: Infectious complication of Human T cell leukemia/lymphoma virus type I infection. Clin Infect Dis. 23:138–145. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Montes M, Sanchez C, Verdonck K, Lake JE, Gonzalez E, Lopez G, Terashima A, Nolan T, Lewis DE, Gotuzzo E and White AC Jr: Regulatory T cell expansion in HTLV-1 and strongyloidiasis co-infection is associated with reduced IL-5 responses to strongyloides stercoralis antigen. PLoS Negl Trop Dis. 3:e4562009. View Article : Google Scholar : PubMed/NCBI

10 

Marcos LA, Terashima A, Dupont HL and Gotuzzo E: Strongyloides hyperinfection syndrome: An emerging global infectious disease. Trans R Soc Trop Med Hyg. 2:314–318. 2008. View Article : Google Scholar

11 

Sakaguchi S, Wing K, Onishi Y, Prieto-Martin P and Yamaguchi T: Regulatory T cells: How do they suppress immune responses? Int Immunol. 21:1105–1111. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Suzuki S, Masaki A, Ishida T, Ito A, Mori F, Sato F, Narita T, Ri M, Kusumoto S, Komatsu H, et al: Tax is a potential molecular target for immunotherapy of adult T-cell leukemia/lymphoma. Cancer Sci. 3:1764–1773. 2012. View Article : Google Scholar

13 

Seiki M, Hattori S, Hirayama Y and Yoshida M: Human adult T-cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci USA. 80:pp. 3618–3622. 1983; View Article : Google Scholar : PubMed/NCBI

14 

Franchini G: Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection. Blood. 86:3619–3639. 1995.PubMed/NCBI

15 

Jin DY, Spencer F and Jeang KT: Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Cell. 93:81–91. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ and Ratner L: Development of leukemia in mice transgenic for the Tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci USA. 92:pp. 1057–1061. 1995; View Article : Google Scholar : PubMed/NCBI

17 

Kannagi M: Immunologic control of human T-Cell leukemia virus type I and adult T-cell leukemia. Int J Hematol. 86:113–117. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Takeda S, Maeda M, Morikawa S, Taniguchi Y, Yasunaga J, Nosaka K, Tanaka Y and Matsuoka M: Genetic and epigenetic inactivation of Tax gene in adult T-cell leukemia cells. Int J Cancer. 109:559–567. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Seliger B, Cabrera T, Garrido F and Ferrone S: HLA class I antigen abnormalities and immune escape by malignant cells. Semin Cancer Biol. 12:3–13. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Shimauchi T, Kabashima K and Tokura Y: Adult T-cell leukemia/lymphoma cells from blood and skin tumors express cytotoxic T lymphocyte-associated antigen-4 and Foxp3 but lack suppressor activity toward autologous CD8+ T cells. Cancer Sci. 9:98–106. 2008.

21 

Toulza F, Nosaka K, Takiguchi M, Pagliuca T, Mitsuya H, Tanaka Y, Taylor GP and Bangham CR: Foxp3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia. Int J Cancer. 5:2375–2382. 2009. View Article : Google Scholar

22 

Little AM and Parham P: Polymorphism and evolution of HLA class I and II genes and molecules. Rev Immunogenet. 1:105–123. 1999.PubMed/NCBI

23 

Satou Y, Yasunaga J, Yoshida M and Matsuoka M: HTLV-1 basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci USA. 103:pp. 720–725. 2006; View Article : Google Scholar : PubMed/NCBI

24 

Andersen MH, Pedersen LO, Capeller B, Bröcker EB, Becker JC and Straten P thor: Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients. Cancer Res. 16:5964–5968. 2001.

25 

Schrama D, Pedersen LØ, Keikavoussi P, Andersen MH, Straten Pt, Bröcker EB, Kämpgen E and Becker JC: Aggregation of antigen-specific T cells at the inoculation site of mature dendritic cells. J Invest Dermatol. 9:1443–1448. 2002. View Article : Google Scholar

26 

Harashima N, Kurihara K, Utsunomiya A, Tanosaki R, Hanabuchi S, Masuda M, Ohashi T, Fukui F, Hasegawa A, Masuda T, et al: Graft-versus-Tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation. Cancer Res. 64:391–399. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Ohashi T, Hanabuchi S, Suzuki R, Kato H, Masuda T and Kannagi M: Correlation of major histocompatibility complex class I downregulation with resistance of human T-cell leukemia virus type 1-infected T cells to cytotoxic T-lymphocyte killing in a rat model. J Virol. 76:7010–7019. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, et al: Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. J Clin Oncol. 28:1591–1598. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Tobinai K, Takahashi T and Akinaga S: Targeting chemokine receptor CCR4 in adult T-cell leukemia/lymphoma and other T-cell lymphomas. Curr Hematol Malig Rep. 7:235–240. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Kono K: Current status of cancer immunotherapy. J Stem Cells Regen Med. 30:8–13. 2014.

31 

Tosti G, Cocorocchio E and Pennacchioli E: Anti-cytotoxic T lymphocyte antigen-4 antibodies in melanoma. Clin Cosmet Investig Dermatol. 6:245–256. 2013.PubMed/NCBI

32 

Chambers CA, Kuhns MS, Egen JG and Allison JP: CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol. 19:565–594. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Parekh VV, Lalani S, Kim S, Halder R, Azuma M, Yagita H, Kumar V, Wu L and Kaer LV: PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells. J Immunol. 182:2816–2826. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Andersen MH, Schrama D, Straten P Thor and Becker JC: Cytotoxic T cells. J Invest Dermatol. 126:32–41. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Seliger B, Ritz U and Ferrone S: Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation. Int J Cancer. 118:129–138. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Johnson JM, Nicot C, Fullen J, Ciminale V, Casareto L, Mulloy JC, Jacobson S and Franchini G: Free major histocompatibility complex class I heavy chain is preferentially targeted for degradation by human T-cell leukemia/lymphotropic virus type 1 p12I protein. J Virol. 75:6086–6094. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Francke U and Pellegrino MA: Assignment of the major histocompatibility complex to aregion of the short arm of human chromosome 6. Proc Natl Acad Sci USA. 74:pp. 1147–1151. 1977; View Article : Google Scholar : PubMed/NCBI

38 

Richardson JH, Edwards AJ, Cruickshank JK, Rudge P and Dalgleish AG: In vivo cellular tropism of human T-cell leukemia virus type 1. J Virol. 64:5682–5687. 1990.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ichikawa A, Miyoshi H, Arakawa F, Kiyasu J, Sato K, Niino D, Kimura Y, Yoshida M, Kawano R, Muta H, Muta H, et al: Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function. Oncol Lett 13: 4611-4618, 2017.
APA
Ichikawa, A., Miyoshi, H., Arakawa, F., Kiyasu, J., Sato, K., Niino, D. ... Ohshima, K. (2017). Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function. Oncology Letters, 13, 4611-4618. https://doi.org/10.3892/ol.2017.6067
MLA
Ichikawa, A., Miyoshi, H., Arakawa, F., Kiyasu, J., Sato, K., Niino, D., Kimura, Y., Yoshida, M., Kawano, R., Muta, H., Sugita, Y., Ohshima, K."Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function". Oncology Letters 13.6 (2017): 4611-4618.
Chicago
Ichikawa, A., Miyoshi, H., Arakawa, F., Kiyasu, J., Sato, K., Niino, D., Kimura, Y., Yoshida, M., Kawano, R., Muta, H., Sugita, Y., Ohshima, K."Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function". Oncology Letters 13, no. 6 (2017): 4611-4618. https://doi.org/10.3892/ol.2017.6067
Copy and paste a formatted citation
x
Spandidos Publications style
Ichikawa A, Miyoshi H, Arakawa F, Kiyasu J, Sato K, Niino D, Kimura Y, Yoshida M, Kawano R, Muta H, Muta H, et al: Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function. Oncol Lett 13: 4611-4618, 2017.
APA
Ichikawa, A., Miyoshi, H., Arakawa, F., Kiyasu, J., Sato, K., Niino, D. ... Ohshima, K. (2017). Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function. Oncology Letters, 13, 4611-4618. https://doi.org/10.3892/ol.2017.6067
MLA
Ichikawa, A., Miyoshi, H., Arakawa, F., Kiyasu, J., Sato, K., Niino, D., Kimura, Y., Yoshida, M., Kawano, R., Muta, H., Sugita, Y., Ohshima, K."Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function". Oncology Letters 13.6 (2017): 4611-4618.
Chicago
Ichikawa, A., Miyoshi, H., Arakawa, F., Kiyasu, J., Sato, K., Niino, D., Kimura, Y., Yoshida, M., Kawano, R., Muta, H., Sugita, Y., Ohshima, K."Detection of Tax-specific CTLs in lymph nodes of adult T-cell leukemia/lymphoma patients and its association with Foxp3 positivity of regulatory T-cell function". Oncology Letters 13, no. 6 (2017): 4611-4618. https://doi.org/10.3892/ol.2017.6067
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