Open Access

Clinical analysis of bevacizumab targeting therapy in treating early colorectal carcinoma after operation

  • Authors:
    • Tie-Ling Li
    • Zhi-Guo Sun
    • Xiaoming Jiang
    • Hai-Feng Guo
  • View Affiliations

  • Published online on: April 24, 2017     https://doi.org/10.3892/ol.2017.6087
  • Pages: 4675-4678
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Clinical effects of bevacizumab target therapy in treating early colorectal carcinoma (CRC) after resection were analyzed. Ninety-two patients diagnosed with early CRC and treated with endoscopic mucosal resection for the first time were selected for the study. They were randomly divided into the control group and the observation group with 46 cases in each group. Control group was administered the chemotherapy regimen with oxaliplatin, calcium folinate and 5-fluorouracil, while bevacizumab targeting therapy was given to the observation group. The follow-up median time in these two groups was 30 months. In the observation group, objective response rate and disease control rate were higher than those in the control group, the adverse reaction rate was lower, and the differences were statistically significant (p<0.05). In the observation group, disease-free survival was prolonged (38.6 vs. 30.5 months, p<0.05); the recurrence rate was lower (13.0 vs. 30.4%, p<0.05); the survival rate was improved (91.3 vs. 76.1%, p<0.05). Vascular endothelial growth factor (VEGF) expressions of follow-up serum in these two groups were lower; VEGF expression in the observation group was lower than that in the control group, and the differences had statistical significance (p<0.05). There was no statistical significance in comparison of positive expression in tissue VEGF (p>0.05). In conclusion, after bevacizumab targeting therapy in treating early CRC, VEGF expression of serum was significantly lower; treatment effects improved; adverse drug reaction was reduced; survival time was prolonged; the recurrence rate was reduced; the survival rate improved. It has good application values.
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June-2017
Volume 13 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li T, Sun Z, Jiang X and Guo H: Clinical analysis of bevacizumab targeting therapy in treating early colorectal carcinoma after operation. Oncol Lett 13: 4675-4678, 2017
APA
Li, T., Sun, Z., Jiang, X., & Guo, H. (2017). Clinical analysis of bevacizumab targeting therapy in treating early colorectal carcinoma after operation. Oncology Letters, 13, 4675-4678. https://doi.org/10.3892/ol.2017.6087
MLA
Li, T., Sun, Z., Jiang, X., Guo, H."Clinical analysis of bevacizumab targeting therapy in treating early colorectal carcinoma after operation". Oncology Letters 13.6 (2017): 4675-4678.
Chicago
Li, T., Sun, Z., Jiang, X., Guo, H."Clinical analysis of bevacizumab targeting therapy in treating early colorectal carcinoma after operation". Oncology Letters 13, no. 6 (2017): 4675-4678. https://doi.org/10.3892/ol.2017.6087