Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2017 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2017 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences

  • Authors:
    • Yoshihito Yokoyama
    • Tatsuhiko Shigeto
    • Rie Miura
    • Asami Kobayashi
    • Makito Mizunuma
    • Aisa Yamauchi
    • Masayuki Futagami
    • Hideki Mizunuma
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan
  • Pages: 4933-4938
    |
    Published online on: April 25, 2017
       https://doi.org/10.3892/ol.2017.6095
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Protoporphyrin IX (PpIX) levels are crucial to the antitumor action of photodynamic therapy (PDT). In the present study, the underling molecular mechanisms for the variation in PpIX levels in ovarian cancer cells were investigated. Five ovarian cancer cell lines were subcutaneously grafted onto the backs of nude mice. Once tumors had developed, 5‑aminolevulinic acid methyl ester hydrochloride (methyl‑ALA) was administered intraperitoneally and the tumor was irradiated twice/week. PpIX levels in the tumor were assayed using high‑performance liquid chromatography. Enzymes involved in heme synthesis and degradation were screened using a microarray technique. Expression of the glutathione transferase Omega‑1 (GSTO1) gene involved in the conversion of PpIX into heme in cells was quantified using the reverse transcription‑quantitative polymerase chain reaction. In HTOA, HRA and DISS cells, PDT resulted in significant tumor shrinkage in comparison with the controls. In MCAS and TOV21G cells, no significant alterations in tumor growth were identified compared with the untreated cells. PpIX levels increased significantly in HTOA, DISS and HRA cells compared with in MCAS and TOV21G cells. A comparison of genetic profiles using PDT‑sensitive DISS cells and PDT‑resistant MCAS cells indicated that MCAS cells exhibited significantly increased levels of δ‑aminolevulinate synthase (a rate‑limiting enzyme in heme synthesis), heme oxygenase 2 (an enzyme that degrades heme into biliverdin), and biliverdin reductase B (an enzyme that reduces biliverdin into bilirubin) in comparison with DISS cells. The level of GSTO1 expression in HTOA, HRA and DISS cells was ~2.5‑fold that in MCAS and TOV21G cells. Sensitivity to PDT is related to PpIX levels in cells. The results of the present study suggested that PpIX tends not to accumulate in PDT‑resistant cells despite active heme synthesis and degradation, and that high levels of GSTO1 expression are associated with increased sensitivity to PDT.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Hofstetter G, Concin N, Braicu I, Chekerov R, Sehouli J, Cadron I, van Gorp T, Trillsch F, Mahner S, Ulmer H, et al: The time interval from surgery to start of chemotherapy significantly impacts prognosis in patients with advanced serous ovarian carcinoma-analysis of patient data in the prospective OVCAD study. Gynecol Oncol. 131:15–20. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Akeson M, Zetterqvist BM, Dahllöf K, Brännström M and Horvath G: Effect of adjuvant paclitaxel and carboplatin for advanced stage epithelial ovarian cancer: A population-based cohort study of all patients in western Sweden with long-term follow-up. Acta Obstet Gynecol Scand. 87:1343–1352. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Casson AG: Photofrin PDT for early stage esophageal cancer: A new standard of care? Photodiagnosis Photodyn Ther. 6:155–156. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Ikeda N, Usuda J, Kato H, Ishizumi T, Ichinose S, Otani K, Honda H, Furukawa K, Okunaka T and Tsutsui H: New aspects of photodynamic therapy for central type early stage lung cancer. Lasers Surg Med. 43:749–754. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Spinelli P, Dal Fante M and Mancini A: Current role of laser and photodynamic therapy in gastrointestinal tumors and analysis of a 10-year experience. Semin Surg Oncol. 8:204–213. 1992. View Article : Google Scholar : PubMed/NCBI

7 

Choi MC, Lee C and Kim SJ: Efficacy and safety of photodynamic therapy for cervical intraepithelial neoplasia: A systemic review. Photodiagnosis Photodyn Ther. 11:479–480. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Dougherty TJ, Lawrence G, Kaufman JH, Boyle D, Weishaupt KR and Goldfarb A: Photoradiation in the treatment of recurrent breast carcinoma. J Natl Cancer Inst. 62:231–237. 1979.PubMed/NCBI

9 

Wakui M, Yokoyama Y, Wang H, Shigeto T, Futagami M and Mizunuma H: Efficacy of a methyl ester of 5-aminolevulinic acid in photodynamic therapy for ovarian cancers. J Cancer Res Clin Oncol. 136:1143–1150. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Furuyama K, Harigae H, Kinoshita C, Shimada T, Miyaoka K, Kanda C, Maruyama Y, Shibahara S and Sassa S: Late-onset X-linked sideroblastic anemia following hemodialysis. Blood. 101:4623–4624. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Kikuchi Y, Kizawa I, Oomori K, Miyauchi M, Kita T, Sugita M, Tenjin Y and Kato K: Establishment of a human ovarian cancer cell line capable of forming ascites in nude mice and effects of tranexamic acid on cell proliferation and ascites formation. Cancer Res. 47:592–596. 1987.PubMed/NCBI

12 

Wetterberg L: Acute porphyria and lead poisoning. Lancet. 1:4981966. View Article : Google Scholar : PubMed/NCBI

13 

Ho PS, Hoffman BM, Kang CH and Margoliash E: Control of the transfer of oxidizing equivalents between heme iron and free radical site in yeast cytochrome c peroxidase. J Biol Chem. 1258:4356–4363. 1983.

14 

Kodym R, Calkins PR and Story MD: Anthracycline-induced erythroid differentiation of K562 cells is inhibited by p28, a novel mammalian glutathione-binding stress protein. Leuk Res. 25:151–156. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Paiva L, Hernández A, Martínez V, Creus A, Quinteros D and Marcos R: Association between GSTO2 polymorphism and the urinary arsenic profile in copper industry workers. Environ Res. 110:463–468. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Hofer T, Wenger RH, Kramer MF, Ferreira GC and Gassmann M: Hypoxic up-regulation of erythroid 5-aminolevulinate synthase. Blood. 101:348–350. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Solár P, Koval J, Mikes J, Kleban J, Solárová Z, Lazúr J, Hodorová I, Fedorocko P and Sytkowski AJ: Erythropoietin inhibits apoptosis induced by photodynamic therapy in ovarian cancer cells. Mol Cancer Ther. 7:2263–2271. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Jung KA, Choi BH and Kwak MK: The c-MET/PI3K signaling is associated with cancer resistance to doxorubicin and photodynamic therapy by elevating BCRP/ABCG2 expression. Mol Pharmacol. 87:465–476. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Luna MC, Wong S and Gomer CJ: Photodynamic therapy mediated induction of early response genes. Cancer Res. 54:1374–1380. 1994.PubMed/NCBI

20 

Meng F, Zhang Y, Liu F, Guo X and Xu B: Characterization and mutational analysis of omega-class GST (GSTO1) from Apis cerana cerana, a gene involved in response to oxidative stress. PLoS One. 9:e931002014. View Article : Google Scholar : PubMed/NCBI

21 

Li Z, Sun L, Lu Z, Su X, Yang Q, Qu X, Li L, Song K and Kong B: Enhanced effect of photodynamic therapy in ovarian cancer using a nanoparticle drug delivery system. Int J Oncol. 47:1070–1076. 2015.PubMed/NCBI

22 

Koide Y, Urano Y, Yatsushige A, Hanaoka K, Terai T and Nagano T: Design and development of enzymatically activatable photosensitizer based on unique characteristics of thiazole orange. J Am Chem Soc. 131:6058–6059. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yokoyama Y, Shigeto T, Miura R, Kobayashi A, Mizunuma M, Yamauchi A, Futagami M and Mizunuma H: Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences. Oncol Lett 13: 4933-4938, 2017.
APA
Yokoyama, Y., Shigeto, T., Miura, R., Kobayashi, A., Mizunuma, M., Yamauchi, A. ... Mizunuma, H. (2017). Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences. Oncology Letters, 13, 4933-4938. https://doi.org/10.3892/ol.2017.6095
MLA
Yokoyama, Y., Shigeto, T., Miura, R., Kobayashi, A., Mizunuma, M., Yamauchi, A., Futagami, M., Mizunuma, H."Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences". Oncology Letters 13.6 (2017): 4933-4938.
Chicago
Yokoyama, Y., Shigeto, T., Miura, R., Kobayashi, A., Mizunuma, M., Yamauchi, A., Futagami, M., Mizunuma, H."Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences". Oncology Letters 13, no. 6 (2017): 4933-4938. https://doi.org/10.3892/ol.2017.6095
Copy and paste a formatted citation
x
Spandidos Publications style
Yokoyama Y, Shigeto T, Miura R, Kobayashi A, Mizunuma M, Yamauchi A, Futagami M and Mizunuma H: Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences. Oncol Lett 13: 4933-4938, 2017.
APA
Yokoyama, Y., Shigeto, T., Miura, R., Kobayashi, A., Mizunuma, M., Yamauchi, A. ... Mizunuma, H. (2017). Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences. Oncology Letters, 13, 4933-4938. https://doi.org/10.3892/ol.2017.6095
MLA
Yokoyama, Y., Shigeto, T., Miura, R., Kobayashi, A., Mizunuma, M., Yamauchi, A., Futagami, M., Mizunuma, H."Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences". Oncology Letters 13.6 (2017): 4933-4938.
Chicago
Yokoyama, Y., Shigeto, T., Miura, R., Kobayashi, A., Mizunuma, M., Yamauchi, A., Futagami, M., Mizunuma, H."Differences in the sensitivity of ovarian cancer to photodynamic therapy and the mechanisms for those differences". Oncology Letters 13, no. 6 (2017): 4933-4938. https://doi.org/10.3892/ol.2017.6095
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team