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Article

Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight

  • Authors:
    • Sandra Pierredon
    • Pascale Ribaux
    • Jean‑Christophe Tille
    • Patrick Petignat
    • Marie Cohen
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Faculty of Medicine, Geneva University Hospital, 1211 Geneva 14, Switzerland, Department of Pathology, Geneva University Hospital, 1211 Geneva 14, Switzerland
  • Pages: 4965-4973
    |
    Published online on: April 25, 2017
       https://doi.org/10.3892/ol.2017.6096
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Abstract

Ovarian cancer is one of the most common types of reproductive cancer, and has the highest mortality rate amongst gynecological cancer subtypes. The majority of ovarian cancers are diagnosed at an advanced stage, resulting in a five‑year survival rate of ~30%. Early diagnosis of ovarian cancer has improved the five‑year survival rate to ≥90%, thus the current imperative requirement is to identify biomarkers that would allow the early detection, diagnosis and monitoring of the progression of the disease, or of novel targets for therapy. In the present study, secreted proteins from purified ovarian control, benign and cancer cells were investigated by mass spectrometry, in order to identify novel specific markers that are easy to quantify in patients sera. A total of nine proteins revealed significant differential secretion from control and benign cells, in comparison with ovarian cancer cells. The mRNA expression levels of three of these proteins (Dickkopf protein 3, heat shock protein 10 kDa and gelsolin) were subsequently evaluated by reverse transcription‑quantitative polymerase chain reaction. Combined with the protein level in serum, the present study identified that gelsolin may be a useful marker of ovarian cancer.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-tieulent J and Jemal A: Global Cancer statistics, 2012. Ca Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Latifi A, Luwor RB, Bilandzic M, Nazaretian S, Stenvers K, Pyman J, Zhu H, Thompson EW, Quinn MA, Findlay JK and Ahmed N: Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: Molecular phenotype of chemoresistant ovarian tumors. PLoS One. 7:e468582012. View Article : Google Scholar : PubMed/NCBI

3 

Su Z, Graybill WS and Zhu Y: Detection and monitoring of ovarian cancer. Clin Chim Acta. 415:341–345. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Têtu B, Popa I, Bairati I, L'Esperance S, Bachvarova M, Plante M, Harel F and Bachvarov D: Immunohistochemical analysis of possible chemoresistance markers identified by micro-arrays on serous ovarian carcinomas. Mod Pathol. 21:1002–1010. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Li J, Dowdy S, Tipton T, Podratz K, Lu WG, Xie X and Jiang SW: HE4 as a biomarker for ovarian and endometrial cancer management. Expert Rev Mol Diagn. 9:555–566. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Rein BJ, Gupta S, Dada R, Safi J, Michener C and Agarwal A: Potential markers for detection and monitoring of ovarian cancer. J Oncol. 2011:4759832011. View Article : Google Scholar : PubMed/NCBI

7 

Nguyen L, Cardenas-Goicoechea SJ, Gordon P, Curtin C, Momeni M, Chuang L and Fishman D: Biomarkers for early detection of ovarian cancer. Womens Health (Lond). 9:171–187. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Toss A, de Matteis E, Rossi E, Casa LD, Iannone A, Federico M and Cortesi L: Ovarian cancer: Can proteomics give new insights for therapy and diagnosis? Int J Mol Sci. 14:8271–8290. 2013. View Article : Google Scholar : PubMed/NCBI

9 

An HJ, Kim DS, Park YK, Kim SK, Choi YP, Kang S, Ding B and Cho NH: Comparative proteomics of ovarian epithelial tumors. J Proteome Res. 5:1082–1090. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Cortesi L, Rossi E, Casa L Della, Barchetti A, Nicoli A, Piana S, Abrate M, La Sala GB, Federico M and Iannone A: Protein expression patterns associated with advanced stage ovarian cancer. Electrophoresis. 32:1992–2003. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Faça VM, Ventura AP, Fitzgibbon MP, Pereira-Faça SR, Pitteri SJ, Green AE, Ireton RC, Zhang Q, Wang H, O'Briant KC, et al: Proteomic analysis of ovarian cancer cells reveals dynamic processes of protein secretion and shedding of extra-cellular domains. PLoS One. 3:e24252008. View Article : Google Scholar : PubMed/NCBI

12 

Jackson D, Craven RA, Hutson RC, Graze I, Lueth P, Tonge RP, Hartley JL, Nickson JA, Rayner SJ, Johnston C, et al: Proteomic profiling identifies afamin as a potential biomarker for ovarian cancer. Clin Cancer Res. 13:7370–7379. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Li XQ, Zhang SL, Cai Z, Zhou Y, Ye TM and Chiu JF: Proteomic identification of tumor-associated protein in ovarian serous cystadenocarinoma. Cancer Lett. 275:109–116. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Petri AL, Simonsen AH, Yip TT, Hogdall E, Fung ET, Lundvall L and Hogdall C: Three new potential ovarian cancer biomarkers detected in human urine with equalizer bead technology. Acta Obstet Gynecol Scand. 88:18–26. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Gunawardana CG, Kuk C, Smith CR, Batruch I, Soosaipillai A and Diamandis EP: Comprehensive analysis of conditioned media from ovarian cancer cell lines identifies novel candidate markers of epithelial ovarian cancer. J Proteome Res. 8:4705–4713. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Zhang Y, Xu B, Liu Y, Yao H, Lu N, Li B, Gao J, Guo S, Han N, Qi J, et al: The ovarian cancer-derived secretory/releasing proteome: A repertoire of tumor markers. Proteomics. 12:1883–1891. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Gluck F, Hoogland C, Antinori P, Robin X, Nikitin F, Zufferey A, Pasquarello C, Fétaud V, Dayon L, Muller M, et al: EasyProt-an easy-to-use graphical platform for proteomics data analysis. J Proteomics. 79:146–160. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Epiney M, Ribaux P, Arboit P, Irion O and Cohen M: Comparative analysis of secreted proteins from normal and preeclamptic trophoblastic cells using proteomic approaches. J Proteomics. 75:1771–1777. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Akyol S, Gercel-Taylor C, Reynolds LC and Taylor DD: HSP-10 in ovarian cancer: Expression and suppression of T-cell signaling. Gynecol Oncol. 101:481–486. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Chambers SK: Role of CSF-1 in progression of epithelial ovarian cancer. Future Oncol. 5:1429–1440. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Chambers SK, Kacinski BM, Ivins CM and Carcangiu ML: Overexpression of epithelial macrophage colony-stimulating factor (CSF-1) and CSF-1 receptor: A poor prognostic factor in epithelial ovarian cancer, contrasted with a protective effect of stromal CSF-1. Clin Cancer Res. 3:999–1007. 1997.PubMed/NCBI

22 

Lim HY, Ho QS, Low J, Choolani M and Wong KP: Respiratory competent mitochondria in human ovarian and peritoneal cancer. Mitochondrion. 11:437–443. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Wang H, Rosen DG, Wang H, Fuller GN, Zhang W and Liu J: Insulin-like growth factor-binding protein 2 and 5 are differentially regulated in ovarian cancer of different histologic types. Mod Pathol. 19:1149–1156. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Chambers SK, Wang Y, Gertz RE and Kacinski BM: Macrophage colony-stimulating factor mediates invasion of ovarian cancer cells through urokinase. Cancer Res. 55:1578–1585. 1995.PubMed/NCBI

25 

Toy EP, Azodi M, Folk NL, Zito CM, Zeiss CJ and Chambers SK: Enhanced ovarian cancer tumorigenesis and metastasis by the macrophage colony-stimulating factor. Neoplasia. 11:136–144. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Lancaster JM, Sayer RA, Blanchette C, Calingaert B, Konidari I, Gray J, Schildkraut J, Schomberg DW, Marks JR and Berchuck A: High expression of insulin-like growth factor binding protein-2 messenger RNA in epithelial ovarian cancers produces elevated preoperative serum levels. Int J Gynecol Cancer. 16:1529–1535. 2006. View Article : Google Scholar : PubMed/NCBI

27 

David S, Bucchieri F, Corrao S, Czarnecka AM, Campanella C, Farina F, Peri G, Tomasello G, Sciumè C, Modica G, et al: Hsp10: Anatomic distribution, functions, and involvement in human disease. Front Biosci. 5:768–778. 2013. View Article : Google Scholar

28 

Niehrs C: Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene. 25:7469–7481. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Veeck J and Dahl E: Targeting the Wnt pathway in cancer: The emerging role of Dickkopf-3. Biochim Biophys Acta. 1825:18–28. 2012.PubMed/NCBI

30 

Jiang T, Huang L, Wang S and Zhang S: Clinical significance of serum Dkk-3 in patients with gynecological cancer. J Obstet Gynaecol Res. 36:769–773. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Silacci P, Mazzolai L, Gauci C, Stergiopulos N, Yin HL and Hayoz D: Gelsolin superfamily proteins: Key regulators of cellular functions. Cell Mol Life Sci. 61:2614–2623. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Spinardi L and Witke W: Gelsolin and diseases. Subcell Biochem. 45:55–69. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Noske A, Denkert C, Schober H, Sers C, Zhumabayeva B, Weichert W, Dietel M and Wiechen K: Loss of Gelsolin expression in human ovarian carcinomas. Eur J Cancer. 41:461–469. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Pierredon S, Ribaux P, Tille JC, Petignat P and Cohen M: Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight. Oncol Lett 13: 4965-4973, 2017.
APA
Pierredon, S., Ribaux, P., Tille, J., Petignat, P., & Cohen, M. (2017). Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight. Oncology Letters, 13, 4965-4973. https://doi.org/10.3892/ol.2017.6096
MLA
Pierredon, S., Ribaux, P., Tille, J., Petignat, P., Cohen, M."Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight". Oncology Letters 13.6 (2017): 4965-4973.
Chicago
Pierredon, S., Ribaux, P., Tille, J., Petignat, P., Cohen, M."Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight". Oncology Letters 13, no. 6 (2017): 4965-4973. https://doi.org/10.3892/ol.2017.6096
Copy and paste a formatted citation
x
Spandidos Publications style
Pierredon S, Ribaux P, Tille JC, Petignat P and Cohen M: Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight. Oncol Lett 13: 4965-4973, 2017.
APA
Pierredon, S., Ribaux, P., Tille, J., Petignat, P., & Cohen, M. (2017). Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight. Oncology Letters, 13, 4965-4973. https://doi.org/10.3892/ol.2017.6096
MLA
Pierredon, S., Ribaux, P., Tille, J., Petignat, P., Cohen, M."Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight". Oncology Letters 13.6 (2017): 4965-4973.
Chicago
Pierredon, S., Ribaux, P., Tille, J., Petignat, P., Cohen, M."Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight". Oncology Letters 13, no. 6 (2017): 4965-4973. https://doi.org/10.3892/ol.2017.6096
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