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Article

Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway

  • Authors:
    • On‑Yu Hong
    • Eun‑Mi Noh
    • Hye‑Yeon Jang
    • Young‑Rae Lee
    • Byoung Kil Lee
    • Sung Hoo Jung
    • Jong‑Suk Kim
    • Hyun Jo Youn
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Chonbuk 54907, Republic of Korea, Department of Oral Biochemistry and Institute of Biomaterials Implant, School of Dentistry, Wonkwang University, Iksan, Chonbuk 54538, Republic of Korea, Department of Surgery, Research Institute of Clinical Medicine of Chonbuk National University, Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Chonbuk 54907, Republic of Korea
  • Pages: 441-446
    |
    Published online on: May 2, 2017
       https://doi.org/10.3892/ol.2017.6108
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Abstract

Epigallocatechin gallate (EGCG), a major constituent of green tea, has potential as a treatment for a variety of diseases, including cancer. EGCG induces apoptosis and inhibits tumorigenesis through multiple signaling pathways in breast cancer cells. β‑catenin signaling modulators could be useful in the prevention and therapy of breast cancer. However, the precise anticancer effect of EGCG through the β‑catenin signaling pathway in breast cancer is unclear. The present study investigated the association between β‑catenin expression and clinicopathological factors of breast cancer patients, and the effect of EGCG on β‑catenin expression in breast cancer cells. β‑catenin expression was analyzed according to the clinicopathological factors of 74 patients with breast cancer. All patients were females diagnosed with invasive ductal carcinoma. Western blot analysis revealed that β‑catenin was expressed at higher levels in breast cancer tissue than in normal tissue. β‑catenin expression was associated with lymph node metastasis (P=0.04), tumor‑node‑metastasis stage (P=0.03) and estrogen receptor status (P<0.01). EGCG decreased MDA‑MB‑231 cell viability and significantly downregulated the expression of β‑catenin, phosphorylated Akt and cyclin D1. Remarkably, additive effects of LY294002 and wortmannin, two phosphatidylinositol‑3 kinase inhibitors, were observed. The present results suggest that EGCG inhibits the growth of MDA‑MB‑231 cells through the inactivation of the β‑catenin signaling pathway. Based on these promising results, EGCG may be a potential treatment for triple negative breast cancer patients.
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Copy and paste a formatted citation
Spandidos Publications style
Hong OY, Noh EM, Jang HY, Lee YR, Lee B, Jung S, Kim JS and Youn H: Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway. Oncol Lett 14: 441-446, 2017.
APA
Hong, O., Noh, E., Jang, H., Lee, Y., Lee, B., Jung, S. ... Youn, H. (2017). Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway. Oncology Letters, 14, 441-446. https://doi.org/10.3892/ol.2017.6108
MLA
Hong, O., Noh, E., Jang, H., Lee, Y., Lee, B., Jung, S., Kim, J., Youn, H."Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway". Oncology Letters 14.1 (2017): 441-446.
Chicago
Hong, O., Noh, E., Jang, H., Lee, Y., Lee, B., Jung, S., Kim, J., Youn, H."Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway". Oncology Letters 14, no. 1 (2017): 441-446. https://doi.org/10.3892/ol.2017.6108
Copy and paste a formatted citation
x
Spandidos Publications style
Hong OY, Noh EM, Jang HY, Lee YR, Lee B, Jung S, Kim JS and Youn H: Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway. Oncol Lett 14: 441-446, 2017.
APA
Hong, O., Noh, E., Jang, H., Lee, Y., Lee, B., Jung, S. ... Youn, H. (2017). Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway. Oncology Letters, 14, 441-446. https://doi.org/10.3892/ol.2017.6108
MLA
Hong, O., Noh, E., Jang, H., Lee, Y., Lee, B., Jung, S., Kim, J., Youn, H."Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway". Oncology Letters 14.1 (2017): 441-446.
Chicago
Hong, O., Noh, E., Jang, H., Lee, Y., Lee, B., Jung, S., Kim, J., Youn, H."Epigallocatechin gallate inhibits the growth of MDA‑MB‑231 breast cancer cells via inactivation of the β‑catenin signaling pathway". Oncology Letters 14, no. 1 (2017): 441-446. https://doi.org/10.3892/ol.2017.6108
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