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Article Open Access

Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation

  • Authors:
    • Sun Young Lee
    • Na Ri Lee
    • Dong‑Hyu Cho
    • Jung Soo Kim
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeollabukdo 561‑712, Republic of Korea, Institute of Clinical Medicine, Chonbuk National University‑Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Jeollabukdo 561‑712, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 73-78
    |
    Published online on: May 4, 2017
       https://doi.org/10.3892/ol.2017.6117
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Abstract

The survival of patients with recurrent cervical cancer following irradiation remains poor. Chemotherapy combined with hyperthermia has been demonstrated to improve the response rate. The present study was performed to evaluate the effect of modulated electro‑hyperthermia combined with conventional chemotherapy compared with chemotherapy alone on recurrent cervical cancer previously treated with irradiation. A total of 20 patients were treated with chemotherapy alone, and 18 were treated with chemotherapy combined with modulated electro‑hyperthermia. A single patient was treated with chemo‑radiotherapy as primary treatment and then relapsed; the tumor was inoperable and radio‑refractory upon recurrence. Local metastases, including metastasis of the para‑aortic lymph nodes and adjacent pelvic lymph nodes were included, but distant metastases were excluded. Modulated electro‑hyperthermia was performed three times per week beginning at chemotherapy initiation, and patients underwent a total of 36 sessions. The overall response (complete remission + partial remission + stable disease/progressive disease) to treatment was significantly greater in the group of patients who underwent chemotherapy combined with modulated electro‑hyperthermia (P=0.0461), and at the evaluation conducted at the last follow‑up visit, the response rate was significantly higher (P=0.0218). Additionally, severe complications were not reported. In the present study, of patients with recurrent cervical cancer previously treated with irradiation, the overall response rate for patients treated with chemotherapy combined with modulated electro-hyperthermia was significantly greater than that for those treated with chemotherapy alone.
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Copy and paste a formatted citation
Spandidos Publications style
Lee SY, Lee NR, Cho DH and Kim JS: Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation. Oncol Lett 14: 73-78, 2017.
APA
Lee, S.Y., Lee, N.R., Cho, D., & Kim, J.S. (2017). Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation. Oncology Letters, 14, 73-78. https://doi.org/10.3892/ol.2017.6117
MLA
Lee, S. Y., Lee, N. R., Cho, D., Kim, J. S."Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation". Oncology Letters 14.1 (2017): 73-78.
Chicago
Lee, S. Y., Lee, N. R., Cho, D., Kim, J. S."Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation". Oncology Letters 14, no. 1 (2017): 73-78. https://doi.org/10.3892/ol.2017.6117
Copy and paste a formatted citation
x
Spandidos Publications style
Lee SY, Lee NR, Cho DH and Kim JS: Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation. Oncol Lett 14: 73-78, 2017.
APA
Lee, S.Y., Lee, N.R., Cho, D., & Kim, J.S. (2017). Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation. Oncology Letters, 14, 73-78. https://doi.org/10.3892/ol.2017.6117
MLA
Lee, S. Y., Lee, N. R., Cho, D., Kim, J. S."Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation". Oncology Letters 14.1 (2017): 73-78.
Chicago
Lee, S. Y., Lee, N. R., Cho, D., Kim, J. S."Treatment outcome analysis of chemotherapy combined with modulated electro-hyperthermia compared with chemotherapy alone for recurrent cervical cancer, following irradiation". Oncology Letters 14, no. 1 (2017): 73-78. https://doi.org/10.3892/ol.2017.6117
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