A comparison of clinicopathological features and prognosis in prostate cancer between atomic bomb survivors and control patients

Shoji,Koichi; Teishima,Jun; Hayashi,Tetsutaro; Shinmei,Shunsuke; Akita,Tomoyuki; Sentani,Kazuhiro; Takeshima,Yukio; Arihiro,Koji; Tanaka,Junko; Yasui,Wataru; Matsubara,Akio

doi:10.3892/ol.2017.6119

July-2017 Volume 14 Issue 1

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July-2017 Volume 14 Issue 1

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Article

A comparison of clinicopathological features and prognosis in prostate cancer between atomic bomb survivors and control patients

Authors:
- Koichi Shoji
- Jun Teishima
- Tetsutaro Hayashi
- Shunsuke Shinmei
- Tomoyuki Akita
- Kazuhiro Sentani
- Yukio Takeshima
- Koji Arihiro
- Junko Tanaka
- Wataru Yasui
- Akio Matsubara
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Affiliations: Department of Urology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734‑8551, Japan, Department of Epidemiology, Infectious Disease Control and Prevention, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734‑8551, Japan, Department of Molecular Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734-8551, Japan, Department of Pathology, Hiroshima University Institute of Biomedical and Health Sciences, Hiroshima 734-8551, Japan, Department of Anatomical Pathology, Hiroshima University Hospital, Hiroshima 734‑8551, Japan
Pages: 299-305
|
Published online on: May 4, 2017

https://doi.org/10.3892/ol.2017.6119
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Abstract

An atomic bomb (A-bomb) was dropped on Hiroshima on 6th August 1945. Although numerous studies have investigated cancer incidence and mortality among A-bomb survivors, only a small number have addressed urological cancer in these survivors. The aim of the present study was to investigate the clinicopathological features of prostate cancer (PCa) in A‑bomb survivors. The clinicopathological features and prognosis of PCa were retrospectively reviewed in 212 survivors and 595 control patients between November 1996 and December 2010. The histopathological and clinical outcomes of surgical treatment of PCa were also evaluated in 69 survivors and 162 control patients. Despite the higher age at diagnosis compared with the control group (P=0.0031), survivors were more likely to have been diagnosed with PCa from a health check compared with the control group (P<0.0001). As a consequence, the survivors were found to exhibit metastasis significantly less frequently (199/212, 93.9%) compared with the control patients (521/595, 87.6%; P=0.0076). Prognosis in the two groups was examined, subsequent to a mean length of follow‑up of 44 months. Overall survival (OS) and PCa‑specific survival (CS) were similar between the two groups (OS, P=0.2196; CS, P=0.1017). A‑bomb exposure was not found to be an independent predictor for prognosis by multivariate analysis (OS, P=0.7800; CS, P=0.8688). The clinicopathological features of patients who underwent a prostatectomy were similar except for the diagnosis opportunity between the two groups. Progression‑free survival rates were similar between the two groups (P=0.5630). A‑bomb exposure was not a significant and independent predictor for worsening of progression‑free prognosis by multivariate analysis (P=0.3763). A‑bomb exposure does not appear to exert deleterious effects on the biological aggressiveness of PCa and the prognosis of patients with PCa.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A comparison of clinicopathological features and prognosis in prostate cancer between atomic bomb survivors and control patients

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