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Case Report Open Access

Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review

  • Authors:
    • Hitoshi Yoshimura
    • Seigo Ohba
    • Hisato Yoshida
    • Kyoko Saito
    • Kazuyoshi Inui
    • Rie Yasui
    • Dai Ichikawa
    • Minako Aiki
    • Junichi Kobayashi
    • Shinpei Matsuda
    • Yoshiaki Imamura
    • Kazuo Sano
  • View Affiliations / Copyright

    Affiliations: Department of Dentistry and Oral Surgery, Unit of Sensory and Locomotor Medicine, Division of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui 910‑1193, Japan, Department of Regenerative Oral Surgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852‑8588, Japan, Division of Surgical Pathology, University of Fukui Hospital, Fukui 910‑1193, Japan
    Copyright: © Yoshimura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 127-136
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    Published online on: May 4, 2017
       https://doi.org/10.3892/ol.2017.6121
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Abstract

Denosumab, a human monoclonal antibody directed against the receptor activator of nuclear factor-κβ ligand (RANKL), is used for the treatment of patients with metastatic cancer of the bone or osteoporosis. Recent reports have demonstrated that denosumab can induce osteonecrosis of the jaw (ONJ), but reported cases of this are uncommon. The present study reports the case of an 86‑year‑old male with prostate cancer patient exhibiting bone metastases who developed ONJ whilst receiving denosumab. To elucidate the influence of denosumab on the development of ONJ, the present study also reviewed the literature, including clinical trials and case reports. In the clinical trials, the prevalence of denosumab‑related ONJ was higher in patients with cancer compared with those with osteoporosis. The high risk of ONJ in patients with cancer was thought to be associated with the differing dose and frequency of denosumab administration. The prevalence of ONJ was not significantly different between patients receiving denosumab and bisphoshonate (BP). In the reported cases, denosumab‑related ONJ had a similar clinical presentation to BP‑related ONJ. There was also a tendency for denosumab‑related ONJ to develop in the mandible of elderly patients. Previous invasive dental treatment was a commonly shared characteristic of patients with denosumab‑related ONJ. A complex medical history was also suspected to affect the prevalence. No clear association between the dose or duration of denosumab treatment and the development of ONJ was observed. Although conservative treatments are given for denosumab‑related ONJ, non‑improving cases were managed surgically with primarily positive results. Because denosumab may offer superior results compared with BP for the treatment of metastatic cancer of the bone or osteoporosis, the use of denosumab is expected to increase in the near future. Clinicians should also be aware of the risk factors for denosumab‑related ONJ, in order to aid in its diagnosis. In addition, patients treated with denosumab should receive prophylactic treatment to maintain their oral health prior to, during and after denosumab treatment.
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1 

Yamashita J and McCauley LK: Antiresorptives and osteonecrosis of the jaw. J Evid Based Dent Pract. 12 3 Suppl:S233–S247. 2012. View Article : Google Scholar

2 

Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B and O'Ryan F: American Association of Oral and Maxillofacial Surgeons: American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw-2014 update. J Oral Maxillofac Surg. 72:1938–1956. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Lipton A, Steger GG, Figueroa J, Alvarado C, Solal-Celigny P, Body JJ, de Boer R, Berardi R, Gascon P, Tonkin KS, et al: Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases. J Clin Oncol. 25:4431–4437. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Fizazi K, Lipton A, Mariette X, Body JJ, Rahim Y, Gralow JR, Gao G, Wu L, Sohn W and Jun S: Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates. J Clin Oncol. 27:1564–1571. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Smith MR, Egerdie B, Hernández Toriz N, Feldman R, Tammela TL, Saad F, Heracek J, Szwedowski M, Ke C, Kupic A, et al: Denosumab in men receiving androgen-deprivation therapy for prostate cancer. N Engl J Med. 361:745–755. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, Lichinitser M, Fujiwara Y, Yardley DA, Viniegra M, et al: Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: A randomized, double-blind study. J Clin Oncol. 28:5132–5139. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Henry DH, Costa L, Goldwasser F, Hirsh V, Hungria V, Prausova J, Scagliotti GV, Sleeboom H, Spencer A, Vadhan-Raj S, et al: Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. J Clin Oncol. 29:1125–1132. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Fizazi K, Carducci M, Smith M, Damião R, Brown J, Karsh L, Milecki P, Shore N, Rader M, Wang H, et al: Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study. Lancet. 377:813–822. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Smith MR, Saad F, Coleman R, Shore N, Fizazi K, Tombal B, Miller K, Sieber P, Karsh L, Damião R, et al: Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: Results of a phase 3, randomised, placebo-controlled trial. Lancet. 379:39–46. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Scagliotti GV, Hirsh V, Siena S, Henry DH, Woll PJ, Manegold C, Solal-Celigny P, Rodriguez G, Krzakowski M, Mehta ND, et al: Overall survival improvement in patients with lung cancer and bone metastases treated with denosumab versus zoledronic acid: Subgroup analysis from a randomized phase 3 study. J Thorac Oncol. 7:1823–1829. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Taylor KH, Middlefell LS and Mizen KD: Osteonecrosis of the jaws induced by anti-RANK ligand therapy. Br J Oral Maxillofac Surg. 48:221–223. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Diz P, López-Cedrún JL, Arenaz J and Scully C: Denosumab-related osteonecrosis of the jaw. J Am Dent Assoc. 143:981–984. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Malan J, Ettinger K, Naumann E and Beirne OR: The relationship of denosumab pharmacology and osteonecrosis of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol. 114:671–676. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Pichardo SE, Kuypers SC and van Merkesteyn JP: Denosumab osteonecrosis of the mandible: A new entity? A case report. J Craniomaxillofac Surg. 41:e65–e69. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Olate S, Uribe F, Martinez F, Almeida A and Unibazo A: Osteonecrosis of the jaw in patient with denosumab therapy. Int J Clin Exp Med. 7:3707–3709. 2014.PubMed/NCBI

16 

O'Halloran M, Boyd NM and Smith A: Denosumab and osteonecrosis of the jaws-the pharmacology, pathogenesis and a report of two cases. Aust Dent J. 59:516–519. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Ohga N, Yamazaki Y, Tsuboi K and Kitagawa Y: Healing of osteonecrosis of the jaw (ONJ) after discontinuation of denosumab in a patient with bone metastases of colorectal cancer: A case report and hypothesis. Quintessence Int. 46:621–626. 2015.PubMed/NCBI

18 

You Tm, Lee KH, Lee SH and Park W: Denosumab-related osteonecrosis of the jaw: A case report and management based on pharmacokinetics. Oral Surg Oral Med Oral Pathol Oral Radiol. 120:548–553. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Matsushita Y, Hayashida S, Morishita K, Sakamoto H, Naruse T, Sakamoto Y, Yamada SI, Yanamoto S, Fujita S, Ikeda T and Umeda M: Denosumab-associated osteonecrosis of the jaw affects osteoclast formation and differentiation: Pathological features of two cases. Mol Clin Oncol. 4:191–194. 2016.PubMed/NCBI

20 

Yamagata K, Nagai H, Baba O, Uchida F, Kanno N, Hasegawa S, Yanagawa T and Bukawa H: A case of brain abscess caused by medication-related osteonecrosis of the jaw. Case Rep Dent. 2016:70386182016.PubMed/NCBI

21 

Owosho AA, Blanchard A, Levi L, Kadempour A, Rosenberg H, Yom SK, Farooki A, Fornier M, Huryn JM and Estilo CL: Osteonecrosis of the jaw in patients treated with denosumab for metastatic tumors to the bone: A series of thirteen patients. J Craniomaxillofac Surg. 44:265–270. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons: American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 65:369–376. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE and Mehrotra B: American Association of Oral and Maxillofacial Surgeons: American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws-2009 update. J Oral Maxillofac Surg. 67 5 Suppl:S2–S12. 2009. View Article : Google Scholar

24 

Marx RE: Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic. J Oral Maxillofac Surg. 61:1115–1117. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, et al: Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 361:756–765. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Roux C, Hofbauer LC, Ho PR, Wark JD, Zillikens MC, Fahrleitner-Pammer A, Hawkins F, Micaelo M, Minisola S, Papaioannou N, et al: Denosumab compared with risedronate in postmenopausal women suboptimally adherent to alendronate therapy: Efficacy and safety results from a randomized open-label study. Bone. 58:48–54. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Nakamura T, Matsumoto T, Sugimoto T, Hosoi T, Miki T, Gorai I, Yoshikawa H, Tanaka Y, Tanaka S, Sone T, et al: Clinical trials express: Fracture risk reduction with denosumab in Japanese postmenopausal women and men with osteoporosis: Denosumab fracture intervention randomized placebo controlled trial (DIRECT). J Clin Endocrinol Metab. 99:2599–2607. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Dinca O, Bucur MB, Bodnar D, Vladan C and Bucur A: Extensive osteonecrosis of the mandible after therapy with denosumab following bisphosphoantes therapy. Acta Endo. 10:457–462. 2014. View Article : Google Scholar

29 

Capozzi A, Lello S and Pontecorvi A: The inhibition of RANK-ligand in the management of postmenopausal osteoporosis and related fractures: The role of denosumab. Gynecol Endocrinol. 30:403–408. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Baron R, Ferrari S and Russell RG: Denosumab and bisphosphonates: Different mechanisms of action and effects. Bone. 48:677–692. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Qi WX, Tang LN, He AN, Yao Y and Shen Z: Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: A meta-analysis of seven randomized controlled trials. Int J Clin Oncol. 19:403–410. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Fedele S, Porter SR, D'Aiuto F, Aljohani S, Vescovi P, Manfredi M, Arduino PG, Broccoletti R, Musciotto A, Di Fede O, et al: Nonexposed variant of bisphosphonate-associated osteonecrosis of the jaw: A case series. Am J Med. 123:1060–1064. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Campisi G, Fedele S, Fusco V, Pizzo G, Di Fede O and Bedogni A: Epidemiology, clinical manifestations, risk reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agents. Future Oncol. 10:257–275. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Patel V, McLeod NM, Rogers SN and Brennan PA: Bisphosphonate osteonecrosis of the jaw-a literature review of UK policies versus international policies on bisphosphonates, risk factors and prevention. Br J Oral Maxillofac Surg. 49:251–257. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Coleman RE: Metastatic bone disease: Clinical features, pathophysiology and treatment strategies. Cancer Treat Rev. 27:165–176. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Body JJ, Lipton A, Gralow J, Steger GG, Gao G, Yeh H and Fizazi K: Effects of denosumab in patients with bone metastases with and without previous bisphosphonate exposure. J Bone Miner Res. 25:440–446. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Otto S, Baumann S, Ehrenfeld M and Pautke C: Successful surgical management of osteonecrosis of the jaw due to RANK-ligand inhibitor treatment using fluorescence guided bone resection. J Craniomaxillofac Surg. 41:694–698. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Vyas S, Hameed S and Murugaraj V: Denosumab-associated osteonecrosis of the jaw-a case report. Dent Update. 41:449–450. 2014.PubMed/NCBI

39 

Uyanne J, Calhoun CC and Le AD: Antiresorptive drug-related osteonecrosis of the jaw. Dent Clin North Am. 58:369–384. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Scott LJ and Muir VJ: Denosumab: In the prevention of skeletal-related events in patients with bone metastases from solid tumours. Drugs. 71:1059–1069. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Epstein MS, Ephros HD and Epstein JB: Review of current literature and implications of RANKL inhibitors for oral health care providers. Oral Surg Oral Med Oral Pathol Oral Radiol. 116:e437–e442. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Saad F, Brown JE, van Poznak C, Ibrahim T, Stemmer SM, Stopeck AT, Diel IJ, Takahashi S, Shore N, Henry DH, et al: Incidence, risk factors, and outcomes of osteonecrosis of the jaw: Integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases. Ann Oncol. 23:1341–1347. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O'Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, et al: Diagnosis and management of osteonecrosis of the jaw: A systematic review and international consensus. J Bone Miner Res. 30:3–23. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Ristow O, Otto S, Troeltzsch M, Hohlweg-Majert B and Pautke C: Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ). J Craniomaxillofac Surg. 43:290–293. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Schipmann S, Metzler P, Rössle M, Zemann W, von Jackowski J, Obwegeser JA, Grätz KW and Jacobsen C: Osteopathology associated with bone resorption inhibitors-which role does Actinomyces play? A presentation of 51 cases with systematic review of the literature. J Oral Pathol Med. 42:587–593. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Katsarelis H, Shah NP, Dhariwal DK and Pazianas M: Infection and medication-related osteonecrosis of the jaw. J Dent Res. 94:534–539. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Miller M and Haddad AJ: Cervicofacial actinomycosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 85:496–508. 1998. View Article : Google Scholar : PubMed/NCBI

48 

Hansen T, Kunkel M, Kirkpatrick CJ and Weber A: Actinomyces in infected osteoradionecrosis-underestimated? Hum Pathol. 37:61–67. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Bartkowski SB, Zapala J, Heczko P and Szuta M: Actinomycotic osteomyelitis of the mandible: Review of 15 cases. J Craniomaxillofac Surg. 26:63–67. 1998. View Article : Google Scholar : PubMed/NCBI

50 

Goldberg MH: Diagnosis and treatment of cervicofacial actinomycosis. Oral Maxillofac Surg Clin North Am. 15:51–58. 2003. View Article : Google Scholar : PubMed/NCBI

51 

Kuyama K, Sun Y, Fukui K, Maruyama S, Ochiai E, Fukumoto M, Ikeda N, Kondoh T, Iwadate K, Takagi R, et al: Tumor mimicking actinomycosis of the upper lip: Report of two cases. Oral Med Pathol. 15:95–99. 2011. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yoshimura H, Ohba S, Yoshida H, Saito K, Inui K, Yasui R, Ichikawa D, Aiki M, Kobayashi J, Matsuda S, Matsuda S, et al: Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review. Oncol Lett 14: 127-136, 2017.
APA
Yoshimura, H., Ohba, S., Yoshida, H., Saito, K., Inui, K., Yasui, R. ... Sano, K. (2017). Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review. Oncology Letters, 14, 127-136. https://doi.org/10.3892/ol.2017.6121
MLA
Yoshimura, H., Ohba, S., Yoshida, H., Saito, K., Inui, K., Yasui, R., Ichikawa, D., Aiki, M., Kobayashi, J., Matsuda, S., Imamura, Y., Sano, K."Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review". Oncology Letters 14.1 (2017): 127-136.
Chicago
Yoshimura, H., Ohba, S., Yoshida, H., Saito, K., Inui, K., Yasui, R., Ichikawa, D., Aiki, M., Kobayashi, J., Matsuda, S., Imamura, Y., Sano, K."Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review". Oncology Letters 14, no. 1 (2017): 127-136. https://doi.org/10.3892/ol.2017.6121
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x
Spandidos Publications style
Yoshimura H, Ohba S, Yoshida H, Saito K, Inui K, Yasui R, Ichikawa D, Aiki M, Kobayashi J, Matsuda S, Matsuda S, et al: Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review. Oncol Lett 14: 127-136, 2017.
APA
Yoshimura, H., Ohba, S., Yoshida, H., Saito, K., Inui, K., Yasui, R. ... Sano, K. (2017). Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review. Oncology Letters, 14, 127-136. https://doi.org/10.3892/ol.2017.6121
MLA
Yoshimura, H., Ohba, S., Yoshida, H., Saito, K., Inui, K., Yasui, R., Ichikawa, D., Aiki, M., Kobayashi, J., Matsuda, S., Imamura, Y., Sano, K."Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review". Oncology Letters 14.1 (2017): 127-136.
Chicago
Yoshimura, H., Ohba, S., Yoshida, H., Saito, K., Inui, K., Yasui, R., Ichikawa, D., Aiki, M., Kobayashi, J., Matsuda, S., Imamura, Y., Sano, K."Denosumab-related osteonecrosis of the jaw in a patient with bone metastases of prostate cancer: A case report and literature review". Oncology Letters 14, no. 1 (2017): 127-136. https://doi.org/10.3892/ol.2017.6121
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