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Article

Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance

  • Authors:
    • Ya‑Jing Lv
    • Wei Wang
    • Chu‑Shu Ji
    • Wei Jia
    • Ming‑Ran Xie
    • Bing Hu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui 230001, P.R. China, Department of Thoracic Surgery, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui 230001, P.R. China
  • Pages: 376-382
    |
    Published online on: May 5, 2017
       https://doi.org/10.3892/ol.2017.6124
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Abstract

The present study aimed to investigate the association between periostin (POSTN), epithelial cadherin (E‑cad) and vimentin (Vim) expression levels in esophageal squamous cell carcinoma (ESCC) tissues, and its clinicopathological significance. A total of 58 patients with esophageal cancer were enrolled. Immunohistochemistry was performed to quantify the expression levels of POSTN, E‑cad and Vim. E‑cad expression was reduced in ESCC tissue, which was associated with severe tumor node metastasis (TNM) stage (P<0.001), lymphatic metastasis (P<0.001) and vascular invasion (P=0.026). Conversely, Vim expression was found to be increased in ESCC tissues, and had associations with TNM stage (P=0.039) and lymphatic metastasis (P=0.039). POSTN overexpression observed in ESCC cells was associated with attenuation of E‑cad expression (P<0.001) and elevated expression levels of Vim (P<0.001). Additionally, significant correlations between the overexpression of POSTN in ESCC cells and clinicopathological variables including TNM staging (P=0.009), degree of differentiation (P<0.001), lymphatic metastasis (P=0.009) and vascular invasion (P=0.002) were verified. Multivariate analysis revealed that overexpression of POSTN in ESCC cancer cells is able to predict the poor prognosis of patients independently of overall survival (P=0.022) and disease free survival (P=0.019). The preliminary findings of the present study demonstrate that POSTN is involved in the epithelial‑mesenchymal transition of ESCC cells, and may therefore be a predictive factor for tumor invasion and metastasis, as well as an indicator of poor prognosis for patients with ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Lv YJ, Wang W, Ji CS, Jia W, Xie MR and Hu B: Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance. Oncol Lett 14: 376-382, 2017.
APA
Lv, Y., Wang, W., Ji, C., Jia, W., Xie, M., & Hu, B. (2017). Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance. Oncology Letters, 14, 376-382. https://doi.org/10.3892/ol.2017.6124
MLA
Lv, Y., Wang, W., Ji, C., Jia, W., Xie, M., Hu, B."Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance". Oncology Letters 14.1 (2017): 376-382.
Chicago
Lv, Y., Wang, W., Ji, C., Jia, W., Xie, M., Hu, B."Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance". Oncology Letters 14, no. 1 (2017): 376-382. https://doi.org/10.3892/ol.2017.6124
Copy and paste a formatted citation
x
Spandidos Publications style
Lv YJ, Wang W, Ji CS, Jia W, Xie MR and Hu B: Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance. Oncol Lett 14: 376-382, 2017.
APA
Lv, Y., Wang, W., Ji, C., Jia, W., Xie, M., & Hu, B. (2017). Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance. Oncology Letters, 14, 376-382. https://doi.org/10.3892/ol.2017.6124
MLA
Lv, Y., Wang, W., Ji, C., Jia, W., Xie, M., Hu, B."Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance". Oncology Letters 14.1 (2017): 376-382.
Chicago
Lv, Y., Wang, W., Ji, C., Jia, W., Xie, M., Hu, B."Association between periostin and epithelial-mesenchymal transition in esophageal squamous cell carcinoma and its clinical significance". Oncology Letters 14, no. 1 (2017): 376-382. https://doi.org/10.3892/ol.2017.6124
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