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Article Open Access

Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma

  • Authors:
    • Ying Zhang
    • Hu Wang
    • Kezhou Wu
    • Zhaoyong Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shantou University Medical College, Shantou, Guangdong 515041, P.R. China, Department of Orthopaedic Oncology, First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 35-40
    |
    Published online on: May 5, 2017
       https://doi.org/10.3892/ol.2017.6127
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Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer in Asia, particular in China. However, the pathogenesis of ESCC has not previously been well demonstrated. A major product of lipid peroxidation, 4‑hydroxynonenal (4‑HNE), is considered to be an oxidative stress inducer, as it is involved in the pathogenesis of a number of degenerative diseases, including Alzheimer's disease, atherosclerosis, cataracts and cancer. In order to investigate the association between oxidative stress and the pathogenic process of ESCC, the present study determined the expression levels of 4‑HNE in 23 non‑malignant esophageal epithelial tissues, 11 esophageal carcinoma in situ tissues and 57 ESCC tissues from patients in the Chaoshan area, a high‑risk region for esophageal cancer in China. A significantly higher expression level of 4‑HNE was identified in ESCC tissues compared with that in non‑malignant esophageal epithelial tissues (P<0.05). Furthermore, immunohistochemical analysis demonstrated that expression levels of 4‑HNE were significantly associated with the clinical stage. The patients with positive staining of 4‑HNE revealed a poorer clinical outcome compared with that of patients with negative staining. 4‑HNE was significantly associated with the severity of inflammation and increased with the progression of precancerous lesions (P<0.05). These results provide pathological evidence that oxidative stress is a driving force of ESCC carcinogenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Wang H, Wu K and Liu Z: Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma. Oncol Lett 14: 35-40, 2017.
APA
Zhang, Y., Wang, H., Wu, K., & Liu, Z. (2017). Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma. Oncology Letters, 14, 35-40. https://doi.org/10.3892/ol.2017.6127
MLA
Zhang, Y., Wang, H., Wu, K., Liu, Z."Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma". Oncology Letters 14.1 (2017): 35-40.
Chicago
Zhang, Y., Wang, H., Wu, K., Liu, Z."Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma". Oncology Letters 14, no. 1 (2017): 35-40. https://doi.org/10.3892/ol.2017.6127
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Wang H, Wu K and Liu Z: Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma. Oncol Lett 14: 35-40, 2017.
APA
Zhang, Y., Wang, H., Wu, K., & Liu, Z. (2017). Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma. Oncology Letters, 14, 35-40. https://doi.org/10.3892/ol.2017.6127
MLA
Zhang, Y., Wang, H., Wu, K., Liu, Z."Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma". Oncology Letters 14.1 (2017): 35-40.
Chicago
Zhang, Y., Wang, H., Wu, K., Liu, Z."Expression of 4-hydroxynonenal in esophageal squamous cell carcinoma". Oncology Letters 14, no. 1 (2017): 35-40. https://doi.org/10.3892/ol.2017.6127
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