Flexible magnifying endoscopy with narrow band imaging for the diagnosis of uterine cervical tumors: A cooperative study among gastrointestinal endoscopists and gynecologists to explore a novel microvascular classification system

Nishiyama,Noriko; Kanenishi,Kenji; Mori,Hirohito; Kobara,Hideki; Fujihara,Shintaro; Chiyo,Taiga; Kobayashi,Nobuya; Matsunaga,Tae; Ayaki,Maki; Yachida,Tatsuo; Fujimori,Ayako; Oryu,Makoto; Tenkumo,Chiaki; Ishibashi,Megumi; Hanaoka,Uiko; Hata,Toshiyuki; Miyai,Yumi; Kadota,Kyuichi; Haba,Reiji; Masaki,Tsutomu

doi:10.3892/ol.2017.6157

July-2017 Volume 14 Issue 1

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July-2017 Volume 14 Issue 1

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Article

Flexible magnifying endoscopy with narrow band imaging for the diagnosis of uterine cervical tumors: A cooperative study among gastrointestinal endoscopists and gynecologists to explore a novel microvascular classification system

Authors:
- Noriko Nishiyama
- Kenji Kanenishi
- Hirohito Mori
- Hideki Kobara
- Shintaro Fujihara
- Taiga Chiyo
- Nobuya Kobayashi
- Tae Matsunaga
- Maki Ayaki
- Tatsuo Yachida
- Ayako Fujimori
- Makoto Oryu
- Chiaki Tenkumo
- Megumi Ishibashi
- Uiko Hanaoka
- Toshiyuki Hata
- Yumi Miyai
- Kyuichi Kadota
- Reiji Haba
- Tsutomu Masaki
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa 761‑0793, Japan, Department of Gynecology, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa 761‑0793, Japan, Department of Diagnostic Pathology, Faculty of Medicine, Kagawa University, Miki, Kita, Kagawa 761‑0793, Japan
Pages: 355-362
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Published online on: May 11, 2017

https://doi.org/10.3892/ol.2017.6157
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Abstract

Narrow band imaging with magnifying endoscopy (NBI-ME), which is useful for the assessment of micro‑vessels, has excellent diagnostic potential for early gastrointestinal epithelial neoplasia. Conventional diagnostic tools for uterine cervical epithelial tumors are still unsatisfactory. An accurate diagnostic tool for uterine cervical epithelial tumors is required to preserve the reproductive ability of young women with uterine cervical tumors. Flexible NBI‑ME was performed in patients with cervical squamous cell lesions that required further examinations based on their Pap smear results (cytology ≥ low‑grade squamous intraepithelial lesion) at Kagawa University Hospital between April 2014 and April 2015. NBI‑ME results concordant with the punch biopsy sites were compared with the histological results. A retrospective review of the NBI‑ME images identified abnormal NBI‑ME results regarding micro‑vascular patterns. All images were categorized as having abnormal features. NBI‑ME revealed the following vascular pattern differences of different stage tumors: Dot‑like vessels without irregular arrangements and high density in cervical intraepithelial neoplasia (CIN) CIN1‑CIN2; dot‑like vessels with irregular arrangements and high density in CIN3‑carcinoma in situ; crawling vessels in minimum invasive cancer; and willow branch vessels and new tumor vessels in invasive cancer. NBI‑ME may be an effective diagnostic tool for uterine cervical epithelial tumors, which may lead to the establishment of a novel classification system.

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1	Arbyn M, Autier P and Ferlay J: Burden of cervical cancer in the 27 member states of the European Union: Estimates for 2004. Ann Oncol. 18:1423–1425. 2007. View Article : Google Scholar : PubMed/NCBI
2	Boutas I, Sofoudis C, Kalampokas E, Anastasopoulos C, Kalampokas T and Salakos N: Fertility preservation in women with early stage cervical cancer. Review of the literature. Eur J Gyneacol Oncol. 35:373–377. 2014.
3	Coronado PJ and Fasero M: Correlating the accuracy of colposcopy with practitioner experience when diagnosing cervical pathology using the dynamic spectral imaging system. Gynecol Obstet Invest. 78:224–229. 2014. View Article : Google Scholar : PubMed/NCBI
4	Wentzensen N, Walker JL, Gold MA, Smith KM, Zuna RE, Mathews C, Dunn ST, Zhang R, Moxley K, Bishop E, et al: Multiple biopsies and detection of cervical cancer precursors as colposcopy. J Clin Oncol. 33:83–89. 2015. View Article : Google Scholar : PubMed/NCBI
5	Duggan MA and Nation J: An audit of the cervical cancer screening histories of 246 women with carcinoma. J Low Genit Tract Dis. 16:263–270. 2012. View Article : Google Scholar : PubMed/NCBI
6	Inoue H, Kaga M, Ikeda H, Sato C, Sato H, Minami H, Santi EG, Hayee B and Eleftheriadis N: Magnification endoscopy in esophageal squamous cell carcinoma: A review of the intrapapillary capillary loop classification. Ann Gastroenterol. 28:41–48. 2015.PubMed/NCBI
7	Yao K: How is the VS (vessel plus surface) classification system applicable to magnifying narrow-band imaging examinations of gastric neoplasias initially diagnosed as low-grade adenomas? Gastric Cancer. 15:118–120. 2012. View Article : Google Scholar : PubMed/NCBI
8	Yao K, Oishi T, Matsui T, Yao T and Iwashita A: Novel magnified endoscopic findings of microvascular architecture in intramucosal gastric cancer. Gastrointest Endosc. 56:279–284. 2002. View Article : Google Scholar : PubMed/NCBI
9	Goda K, Dobashi A and Tajiri H: Perspectives on narrow-band imaging endoscopy for superficial squamous neoplasms of the orohypopharynx and esophagus. Dig Endosc. 26 Suppl 1:1–11. 2014. View Article : Google Scholar : PubMed/NCBI
10	Yamada S, Doyama H, Yao K, Uedo N, Ezoe Y, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, et al: An efficient diagnostic strategy for small, depressed early gastric cancer with magnifying narrow-band imaging: A post-hoc analysis of a prospective randomized controlled trial. Gastrointest Endosc. 79:55–63. 2014. View Article : Google Scholar : PubMed/NCBI
11	Ezoe Y, Muto M, Uedo N, Doyama H, Yao K, Oda I, Kaneko K, Kawahara Y, Yokoi C, Sugiura Y, et al: Magnifying narrowband imaging is more accurate than conventional white-light imaging in diagnosis of gastric mucosal cancer. Gastoroentelrology. 141:2017–2025.e3. 2011. View Article : Google Scholar
12	Tanaka S and Sano Y: Aim to unify the narrow band imaging (NBI) magnifying classification for colorectal tumors: Current status in Japan from a summary of the consensus symposium in the 79th annual meeting of the Japan gastroenterological endoscopy society. Dig Endosc. 23 Suppl 1:131–139. 2011. View Article : Google Scholar : PubMed/NCBI
13	Gono K, Obi T, Yamaguchi M, Ohyama N, Machida H, Sano Y, Yoshida S, Hamamoto Y and Endo T: Appearance of enhanced tissue features in narrow-band endoscopic imaging. J Biomed Opt. 9:568–577. 2004. View Article : Google Scholar : PubMed/NCBI
14	Fujii T, Nakamura M, Kameyama K, Saito M, Nishio H, Ohno A, Hirao N, Iwata T, Tsukazaki K and Aoki D: Digital colposcopy for the diagnosis of cervical adenocarcinoma using a narrow band imaging system. Int J Gynecol Cancer. 20:605–610. 2010. View Article : Google Scholar : PubMed/NCBI
15	Kisu J, Banno K, Kobayashi Y, Ono A, Masuda K, Ueki A, Nomura H, Hirasawa A, Abe T, Kouyama K, et al: Flexible hysteroscopy with narrow band imaging (NBI) for endoscopic diagnosis of malignant endometrial lesions. Int J Oncol. 38:613–618. 2011.PubMed/NCBI
16	Kobara H, Mori H, Rafiq K, Fujihara S, Nishiyama N, Morishita A, Goda Y, Kanenishi K, Hata T and Masaki T: Application of endoscopic hemostatic forceps for uterine cervical bleeding. Gastrointest Endosc. 81:234–235. 2015. View Article : Google Scholar : PubMed/NCBI
17	Nakanishi H, Doyama H, Takemura K, Yoshida N, Tsuji K, Takeda Y, Asahina Y, Kito Y, Ito R, Hayashi T, et al: Detection of pharyngeal cancer in the overall population undergoing upper GI endoscopy by using narrow-band imaging: A single-center experience, 2009–2012. Gastrointest Endosc. 79:558–564. 2014. View Article : Google Scholar : PubMed/NCBI
18	Okada K, Tsuchida T, Ishiyama A, Taniguchi T, Suzuki S, Horiuchi Y, Matsuo Y, Yoshizawa N, Suganuma T, Omae M, et al: Endoscopic mucosal resection and endoscopic submucosal dissection for en bloc resection of superficial pharyngeal carcinomas. Endoscopy. 44:556–564. 2012. View Article : Google Scholar : PubMed/NCBI
19	Hiki N, Nunobe S, Matsuda T, Hirasawa T, Yamamoto Y and Yamaguchi T: Laparoscopic endoscopic cooperative surgery. Dig Endosc. 27:197–204. 2015. View Article : Google Scholar : PubMed/NCBI
20	Mori H, Kobara H, Fujihara S, Nishiyama N, Ayagi M, Matsunaga T, Yachida T and Masaki T: Establishment of the hybrid endoscopic full-thickness resection of gastric gastrointestinal stromal tumors. Mol Clin Oncol. 3:18–22. 2015.PubMed/NCBI
21	Federlein M, Borchert D, Müller V, Atas Y, Fritze F, Burghardt J, Elling D and Gellert K: Transvaginal video-assisted cholecystectomy in clinical practice. Surg Endosc. 24:2444–2452. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Flexible magnifying endoscopy with narrow band imaging for the diagnosis of uterine cervical tumors: A cooperative study among gastrointestinal endoscopists and gynecologists to explore a novel microvascular classification system

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