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Article Open Access

Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells

  • Authors:
    • Jehn‑Hwa Kuo
    • An‑Cheng Huang
    • Jen‑Jyh Lin
    • Kuang‑Chi Lai
    • Rick Sai‑Chuen Wu
    • Jiun‑Long Yang
    • Bin‑Chuan Ji
    • Mei‑Due Yang
    • Yung‑Lin Chu
    • Jing‑Gung Chung
  • View Affiliations / Copyright

    Affiliations: Special Class of Healthcare, Industry Management, Central Taiwan University of Science and Technology, Taichung 40601, Taiwan, R.O.C., Department of Nursing, St. Mary's Junior College of Medicine, Nursing and Management, Yilan 26644, Taiwan, R.O.C., Division of Cardiology, China Medical University Hospital, Taichung 404, Taiwan, R.O.C., School of Medicine, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan, R.O.C., Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan, R.O.C., Department of Surgery, China Medical University Hospital, Taichung 404, Taiwan, R.O.C., International Master's Degree Program in Food Science, Department of Food Science, International College, National Pingtung University of Science and Technology, Pingtung 91201, Taiwan, R.O.C., Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan, R.O.C.
    Copyright: © Kuo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 234-240
    |
    Published online on: May 12, 2017
       https://doi.org/10.3892/ol.2017.6168
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Abstract

Cantharidin (CTD) is a natural toxin in beetles of the Mylabris genus (blister beetle), which has been revealed to induce cell death in various types of human cancer cells. However, to the best of our knowledge, no previous studies have investigated the effect of CTD on the expression of genes and their associated signaling pathways in human bladder carcinoma cells. In the present study, CTD‑induced cell morphological changes and apoptosis were observed using phase‑contrast microscopy and the terminal deoxynucleotidyl transferase dUTP nick end labeling assay, respectively, in TSGH‑8301 human bladder carcinoma cells. In addition, a complementary DNA microarray analysis demonstrated that CTD treatment led to a >2‑fold upregulation of 269 genes. For example, the DNA damage‑associated gene DNA‑damage‑inducible transcript 3 had a 4.75‑fold upregulation. Furthermore, another 286 genes were >2‑fold downregulated in response to CTD treatment. Matrix-remodeling associated 5, which is associated with cell migration and invasion, was downregulated 7.98-fold.
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1 

Knowles MA: The genetics of transitional cell carcinoma: Progress and potential clinical application. BJU Int. 84:412–427. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Pudasaini S, Subedi N, Prasad KB, Rauniyar SK, Joshi BR and Bhomi KK: Cystoscopic bladder biopsies: A histopathological study. Nepal Med Coll J. 16:9–12. 2014.PubMed/NCBI

3 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Parkin DM: The global burden of urinary bladder cancer. Scand J Urol Nephrol Suppl. 12–20. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Boffetta P: Tobacco smoking and risk of bladder cancer. Scand J Urol Nephrol Suppl. 45–54. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Prasad SM, Decastro GJ and Steinberg GD: Medscape: Urothelial carcinoma of the bladder: Definition, treatment and future efforts. Nat Rev Urol. 8:631–642. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Ministry of Health and Welfare (Taiwan), . Taiwan Statistics of causes of death 2006. Ministry of Health and Welfare (Taiwan); Taipei City: 2006

9 

Moed L, Shwayder TA and Chang MW: Cantharidin revisited: A blistering defense of an ancient medicine. Arch Dermatol. 137:1357–1360. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Wang GS: Medical uses of mylabris in ancient China and recent studies. J Ethnopharmacol. 26:147–162. 1989. View Article : Google Scholar : PubMed/NCBI

11 

Karras DJ, Farrell SE, Harrigan RA, Henretig FM and Gealt L: Poisoning from ‘Spanish fly’ (cantharidin). Am J Emerg Med. 14:478–483. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Swingle M, Ni L and Honkanen RE: Small-molecule inhibitors of ser/thr protein phosphatases: Specificity, use and common forms of abuse. Methods Mol Biol. 365:23–38. 2007.PubMed/NCBI

13 

Li W, Xie L, Chen Z, Zhu Y, Sun Y, Miao Y, Xu Z and Han X: Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis. Cancer Sci. 101:1226–1233. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Li W, Chen Z, Gong FR, Zong Y, Chen K, Li DM, Yin H, Duan WM, Miao Y, Tao M, et al: Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway. Eur J Cancer. 47:2654–2664. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Li W, Chen Z, Zong Y, Gong F, Zhu Y, Zhu Y, Lv J, Zhang J, Xie L, Sun Y, et al: PP2A inhibitors induce apoptosis in pancreatic cancer cell line PANC-1 through persistent phosphorylation of IKKα and sustained activation of the NF-κB pathway. Cancer Lett. 304:117–127. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Huh JE, Kang KS, Chae C, Kim HM, Ahn KS and Kim SH: Roles of p38 and JNK mitogen-activated protein kinase pathways during cantharidin-induced apoptosis in U937 cells. Biochem Pharmacol. 67:1811–1818. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Chang C, Zhu YQ, Mei JJ, Liu SQ and Luo J: Involvement of mitochondrial pathway in NCTD-induced cytotoxicity in human hepG2 cells. J Exp Clin Cancer Res. 29:1452010. View Article : Google Scholar : PubMed/NCBI

18 

Huang WW, Ko SW, Tsai HY, Chung JG, Chiang JH, Chen KT, Chen YC, Chen HY, Chen YF and Yang JS: Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways. Int J Oncol. 38:1067–1073. 2011.PubMed/NCBI

19 

Zhang WD, Zhao HR, Yan Y, Wang XH, Zong ZH and Liu Y: Apoptosis induced by cantharidin in human pulmonary carcinoma cells A549 and its molecular mechanisms. Zhonghua Zhong Liu Za Zhi. 27:330–334. 2005.(In Chinese). PubMed/NCBI

20 

Huan SK, Lee HH, Liu DZ, Wu CC and Wang CC: Cantharidin-induced cytotoxicity and cyclooxygenase 2 expression in human bladder carcinoma cell line. Toxicology. 223:136–143. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Li W, Li DM, Chen K, Chen Z, Zong Y, Yin H, Xu ZK, Zhu Y, Gong FR and Tao M: Development of a gene therapy strategy to target hepatocellular carcinoma based inhibition of protein phosphatase 2A using the α-fetoprotein promoter enhancer and pgk promoter: An in vitro and in vivo study. BMC Cancer. 12:5472012. View Article : Google Scholar : PubMed/NCBI

22 

Xie X, Wu MY, Shou LM, Chen LP, Gong FR, Chen K, Li DM, Duan WM, Xie YF, Mao YX, et al: Tamoxifen enhances the anticancer effect of cantharidin and norcantharidin in pancreatic cancer cell lines through inhibition of the protein kinase C signaling pathway. Oncol Lett. 9:837–844. 2015.PubMed/NCBI

23 

Hsiao YP, Tsai CH, Wu PP, Hsu SC, Liu HC, Huang YP, Yang JH and Chung JG: Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin A and triggers apoptosis through reactive oxygen species and the mitochondriadependent pathways of A375.S2 human melanoma cells. Int J Oncol. 45:2393–2402. 2014.PubMed/NCBI

24 

Hsia TC, Yu CC, Hsu SC, Tang NY, Lu HF, Huang YP, Wu SH, Lin JG and Chung JG: Cantharidin induces apoptosis of H460 human lung cancer cells through mitochondria-dependent pathways. Int J Oncol. 45:245–254. 2014.PubMed/NCBI

25 

Kuo JH, Chu YL, Yang JS, Lin JP, Lai KC, Kuo HM, Hsia TC and Chung JG: Cantharidin induces apoptosis in human bladder cancer TSGH 8301 cells through mitochondria-dependent signal pathways. Int J Oncol. 37:1243–1250. 2010.PubMed/NCBI

26 

Evans HJ and Prosser J: Tumor-suppressor genes: Cardinal factors in inherited predisposition to human cancers. Environ Health Perspect. 98:25–37. 1992. View Article : Google Scholar : PubMed/NCBI

27 

Tang C, Guo J, Chen H, Yao CJ, Zhuang DX, Wang Y, Tang WJ, Ren G, Yao Y, Wu JS, et al: Gene mutation profiling of primary glioblastoma through multiple tumor biopsy guided by 1H-magnetic resonance spectroscopy. Int J Clin Exp Pathol. 8:5327–5335. 2015.PubMed/NCBI

28 

Heneghan HM, Miller N and Kerin MJ: MiRNAs as biomarkers and therapeutic targets in cancer. Curr Opin Pharmacol. 10:543–550. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Osborne C, Wilson P and Tripathy D: Oncogenes and tumor suppressor genes in breast cancer: Potential diagnostic and therapeutic applications. Oncologist. 9:361–377. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Ai X, Jia ZM, Wang J, Di GP, Zhang XU, Sun F, Zang T and Liao X: Bioinformatics analysis of the target gene of fibroblast growth factor receptor 3 in bladder cancer and associated molecular mechanisms. Oncol Lett. 10:543–549. 2015.PubMed/NCBI

31 

Spiegelberg C, Giedl J, Gaisa NT, Rogler A, Riener MO, Filbeck T, Burger M, Ruemmele P, Hartmann A and Stoehr R: Frequency of activating mutations in FGFR2 exon 7 in bladder tumors from patients with early-onset and regular-onset disease. Int J Clin Exp Pathol. 7:1708–1713. 2014.PubMed/NCBI

32 

Hsia TC, Yu CC, Hsu SC, Tang NY, Lu HF, Yu CS, Wu SH, Lin JG and Chung JG: cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro. Mol Med Rep. 12:1030–1042. 2015.PubMed/NCBI

33 

Lu CC, Yang JS, Chiang JH, Hour MJ, Lin KL, Lee TH and Chung JG: Cell death caused by quinazolinone HMJ-38 challenge in oral carcinoma CAL 27 cells: Dissections of endoplasmic reticulum stress, mitochondrial dysfunction and tumor xenografts. Biochim Biophys Acta. 1840:2310–2320. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Chou YC, Chang MY, Wang MJ, Liu HC, Chang SJ, Harnod T, Hung CH, Lee HT, Shen CC and Chung JG: Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ Toxicol. 32:176–187. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, et al: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 483:603–607. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Yeh MY, Yu DS, Chen SC, Lin MS, Chang SY, Ma CP and Han SH: Establishment and characterization of a human urinary bladder carcinoma cell line (TSGH-8301). J Surg Oncol. 37:177–184. 1988. View Article : Google Scholar : PubMed/NCBI

37 

Huang YP, Ni CH, Lu CC, Chiang JH, Yang JS, Ko YC, Lin JP, Kuo JH, Chang SJ and Chung JG: Suppressions of Migration and Invasion by Cantharidin in TSGH-8301 human bladder carcinoma cells through the inhibitions of matrix metalloproteinase-2/−9 signaling. Evid Based Complement Alternat Med. 2013:1902812013.PubMed/NCBI

38 

Su CC, Liu SH, Lee KI, Huang KT, Lu TH, Fang KM, Wu CC, Yen CC, Lai CH, Su YC and Huang CF: Cantharidin induces apoptosis through the calcium/PKC-regulated endoplasmic reticulum stress pathway in human bladder cancer cells. Am J Chin Med. 43:581–600. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Hensel J, Duex JE, Owens C, Dancik GM, Edwards MG, Frierson HF and Theodorescu D: Patient mutation directed shRNA screen uncovers novel bladder tumor growth suppressors. Mol Cancer Res. 13:1306–1315. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Ayala F, Dewar R, Kieran M and Kalluri R: Contribution of bone microenvironment to leukemogenesis and leukemia progression. Leukemia. 23:2233–2241. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J, Davis A, Mongare MM, Gould J, Frederick DT, et al: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature. 487:500–504. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, et al: Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature. 487:505–509. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kuo JH, Huang AC, Lin JJ, Lai KC, Wu RS, Yang JL, Ji BC, Yang MD, Chu YL, Chung JG, Chung JG, et al: Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells. Oncol Lett 14: 234-240, 2017.
APA
Kuo, J., Huang, A., Lin, J., Lai, K., Wu, R.S., Yang, J. ... Chung, J. (2017). Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells. Oncology Letters, 14, 234-240. https://doi.org/10.3892/ol.2017.6168
MLA
Kuo, J., Huang, A., Lin, J., Lai, K., Wu, R. S., Yang, J., Ji, B., Yang, M., Chu, Y., Chung, J."Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells". Oncology Letters 14.1 (2017): 234-240.
Chicago
Kuo, J., Huang, A., Lin, J., Lai, K., Wu, R. S., Yang, J., Ji, B., Yang, M., Chu, Y., Chung, J."Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells". Oncology Letters 14, no. 1 (2017): 234-240. https://doi.org/10.3892/ol.2017.6168
Copy and paste a formatted citation
x
Spandidos Publications style
Kuo JH, Huang AC, Lin JJ, Lai KC, Wu RS, Yang JL, Ji BC, Yang MD, Chu YL, Chung JG, Chung JG, et al: Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells. Oncol Lett 14: 234-240, 2017.
APA
Kuo, J., Huang, A., Lin, J., Lai, K., Wu, R.S., Yang, J. ... Chung, J. (2017). Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells. Oncology Letters, 14, 234-240. https://doi.org/10.3892/ol.2017.6168
MLA
Kuo, J., Huang, A., Lin, J., Lai, K., Wu, R. S., Yang, J., Ji, B., Yang, M., Chu, Y., Chung, J."Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells". Oncology Letters 14.1 (2017): 234-240.
Chicago
Kuo, J., Huang, A., Lin, J., Lai, K., Wu, R. S., Yang, J., Ji, B., Yang, M., Chu, Y., Chung, J."Cantharidin alters the expression of genes associated with the NKG2D-associated immune response in TSGH-8301 human bladder carcinoma cells". Oncology Letters 14, no. 1 (2017): 234-240. https://doi.org/10.3892/ol.2017.6168
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