MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection

  • Authors:
    • Er‑Lei Zhang
    • Jin Gu
    • Zun‑Yi Zhang
    • Ke‑Shuai Dong
    • Bin‑Yong Liang
    • Zhi‑Yong Huang
  • View Affiliations

  • Published online on: May 16, 2017     https://doi.org/10.3892/ol.2017.6178
  • Pages: 971-976
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Abstract

Numerous studies have suggested that microRNAs (miRNAs) potently affect hepatocarcinogenesis. However, the miRNA expression profiling in patients with hepatocellular carcinoma (HCC) of familial aggregation and hepatitis B virus (HBV) infection has not been elucidated. In the present study, the plasma miRNA expression profiles of 3 patients with HCC with familial aggregation of HCC and HBV infection and 1 healthy volunteer were examined by microarray analysis, in order to identify relevant miRNAs involved in the pathogenesis of HCC with familial aggregation and HBV infection. The results indicated that 26 miRNAs exhibited a ≥20‑fold increase or decrease in the plasma of patients with HCC, compared with the healthy control (24 upregulated and 2 downregulated). Among these altered miRNAs, 15 of them have been reported in HCC. The other 11 miRNAs have never been reported in HCC. These differentially‑expressed miRNAs may be potential molecular markers for HCC pathogenesis and development.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang EL, Gu J, Zhang ZY, Dong KS, Liang BY and Huang ZY: MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection. Oncol Lett 14: 971-976, 2017
APA
Zhang, E., Gu, J., Zhang, Z., Dong, K., Liang, B., & Huang, Z. (2017). MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection. Oncology Letters, 14, 971-976. https://doi.org/10.3892/ol.2017.6178
MLA
Zhang, E., Gu, J., Zhang, Z., Dong, K., Liang, B., Huang, Z."MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection". Oncology Letters 14.1 (2017): 971-976.
Chicago
Zhang, E., Gu, J., Zhang, Z., Dong, K., Liang, B., Huang, Z."MicroRNA expression profiling in patients with hepatocellular carcinoma of familial aggregation and hepatitis B virus infection". Oncology Letters 14, no. 1 (2017): 971-976. https://doi.org/10.3892/ol.2017.6178