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Article Open Access

Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines

  • Authors:
    • Eriko Tanabe
    • Misaho Kitayoshi
    • Kiyomu Fujii
    • Hitoshi Ohmori
    • Yi Luo
    • Yui Kadochi
    • Shiori Mori
    • Rina Fujiwara
    • Yukiko Nishiguchi
    • Takamitsu Sasaki
    • Hiroki Kuniyasu
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Pathology, Nara Medical University, Kashihara, Nara 634‑8521, Japan, Department of Gastroenterological Surgery, Fukuoka University School of Medicine, Fukuoka 814‑0133, Japan
    Copyright: © Tanabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 681-686
    |
    Published online on: May 17, 2017
       https://doi.org/10.3892/ol.2017.6190
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Abstract

The present study investigated the effects of two major dietary fatty acid components, linoleic acid (LA) and elaidic acid (EA), on the antitumor effects of 5-fluorouracil (5‑FU) in the LL2, CT26 and CMT93 mouse cancer cell lines. Concurrent treatment with LA and 5‑FU elicited a decreased cell viability compared with treatment with 5‑FU alone. In addition, increased inhibition of growth was observed following concurrent treatment with EA and 5‑FU. Sequential treatment of LA followed by 5‑FU abrogated the anticancer effects of 5‑FU, and treatment with EA followed by 5‑FU increased cancer cell growth in addition to abrogating the anticancer effects of 5‑FU. The expression of the stem cell markers CD133 and nucleostemin (NS) increased in all three cell lines treated concurrently with 5‑FU and either LA or EA when compared with cells treated with 5‑FU alone. Aldehyde dehydrogenase activity in the cancer stem cells (CSCs), in response to concurrent treatment with 5‑FU and either LA or EA, was increased compared with 5‑FU treatment alone. 5‑FU inhibited the growth of CT26 tumors, but co‑treatment with either LA or EA abrogated this effect. NS‑positive CSCs were more abundant in CT26 tumors treated with 5‑FU and either LA or EA compared with those treated with 5‑FU alone. The results of the present study suggested that, rather than altering the sensitivity of cancer cells to 5‑FU, LA and EA may promote the survival of CSCs. The results indicated that dietary composition during chemotherapy is an important issue.
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1 

Pietrzyk L, Torres A, Maciejewski R and Torres K: Obesity and obese-related chronic low-grade inflammation in promotion of colorectal cancer development. Asian Pac J Cancer Prev. 16:4161–4168. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Uzunlulu M, Caklili O Telci and Oguz A: Association between metabolic syndrome and cancer. Ann Nutr Metab. 68:173–179. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Cappellani A, Zanghi A, Di Vita M, Cavallaro A, Piccolo G, Veroux P, Lo Menzo E, Cavallaro V, De Paoli P, Veroux M and Berretta M: Strong correlation between diet and development of colorectal cancer. Front Biosci (Landmark Ed). 18:190–198. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Rose DP: Dietary fatty acids and cancer. Am J Clin Nutr. 66 4 Suppl:998S–1003S. 1997.PubMed/NCBI

5 

Zhang W, Thornton WH and MacDonald RS: Insulin-like growth factor-I and II receptor expression in rat colon mucosa are affected by dietary lipid intake. J Nutr. 128:158–165. 1998.PubMed/NCBI

6 

Singh J, Hamid R and Reddy BS: Dietary fish oil inhibits the expression of farnesyl protein transferase and colon tumor development in rodents. Carcinogenesis. 19:985–989. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Singh J, Hamid R and Reddy BS: Dietary fat and colon cancer: Modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. Cancer Res. 57:3465–3470. 1997.PubMed/NCBI

8 

Ohmori H, Luo Y, Fujii K, Sasahira T, Shimomoto T, Denda A and Kuniyasu H: Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. Pathobiology. 77:210–217. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Zhou S, Wang G, Chen B and Wang P: Effect of dietary fatty acids on tumorigenesis of colon cancer induced by methylnitrosourea in rats. J Environ Pathol Toxicol Oncol. 19:81–86. 2000.PubMed/NCBI

10 

Rao CV, Hirose Y, Indranie C and Reddy BS: Modulation of experimental colon tumorigenesis by types and amounts of dietary fatty acids. Cancer Res. 61:1927–1933. 2001.PubMed/NCBI

11 

Ohmori H, Sasahira T, Fujii K, Yi L, Shimomoto T and Kuniyasu H: Linoleic acid-induced growth suppression induces quiescent cancer cell nests in nude mice. Pathobiology. 75:226–232. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Luo Y, Chihara Y, Fujimoto K, Sasahira T, Kuwada M, Fujiwara R, Fujii K, Ohmori H and Kuniyasu H: High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy. Eur J Cancer. 49:741–751. 2013. View Article : Google Scholar : PubMed/NCBI

13 

King IB, Kristal AR, Schaffer S, Thornquist M and Goodman GE: Serum trans-fatty acids are associated with risk of prostate cancer in beta-Carotene and Retinol Efficacy Trial. Cancer Epidemiol Biomarkers Prev. 14:988–992. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Vinikoor LC, Schroeder JC, Millikan RC, Satia JA, Martin CF, Ibrahim J, Galanko JA and Sandler RS: Consumption of trans-fatty acid and its association with colorectal adenomas. Am J Epidemiol. 168:289–297. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Kuniyasu H, Ohmori H, Fujii K, et al: Significance of trans fatty acids in colorectal cancerCurrent Research in Cancer. 9. Sunitha M: Research Media; Kerala, India: pp. 21–29. 2015

16 

Ohmori H, Fujii K, Kadochi Y, Mori S, Nishiguchi Y, Fujiwara R, Kishi S, Sasaki T and Kuniyasu H: Elaidic acid, a trans fatty acid, enhances the metastasis of colorectal cancer cells. Pathobiology. 84:144–151. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Fujii K, Luo Y, Fujiwara-Tani R, Kishi S, He S, Yang S, Sasaki T, Ohmori H and Kuniyasu H: Pro-metastatic intracellular signaling of elaidic trans fatty acid. Int J Oncol. 50:85–92. 2017.PubMed/NCBI

18 

U.S. Food and Drug Administration, . Final Determination Regarding Partially Hydrogenated Oils. U.S. Food and Drug Administration; Silver Spring, MD: 2015

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Leirós GJ and Balañá ME: Metastatic cancer stem cells: New molecular targets for cancer therapy. Curr Pharm Biotechnol. 12:1909–1922. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Gaur P, Sceusi EL, Samuel S, Xia L, Fan F, Zhou Y, Lu J, Tozzi F, Lopez-Berestein G, Vivas-Mejia P, et al: Identification of cancer stem cells in human gastrointestinal carcinoid and neuroendocrine tumors. Gastroenterology. 141:1728–1737. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Bultman SJ: Interplay between diet, gut microbiota, epigenetic events and colorectal cancer. Mol Nutr Food Res. 61:2017. View Article : Google Scholar : PubMed/NCBI

23 

Rao CV and Reddy BS: Modulating effect of amount and types of dietary fat on ornithine decarboxylase, tyrosine protein kinase and prostaglandins production during colon carcinogenesis in male F344 rats. Carcinogenesis. 14:1327–1333. 1993. View Article : Google Scholar : PubMed/NCBI

24 

Slattery ML, Benson J, Ma KN, Schaffer D and Potter JD: Trans-fatty acids and colon cancer. Nutr Cancer. 39:170–175. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Gupta RA and Dubois RN: Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer. 1:11–21. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Moonen HJ, Dommels YE, van Zwam M, van Herwijnen MH, Kleinjans JC, Alink GM and de Kok TM: Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 40:180–188. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Rao YP, Kumar PP and Lokesh BR: Molecular mechanisms for the modulation of selected inflammatory markers by dietary rice bran oil in rats fed partially hydrogenated vegetable fat. Lipids. 51:451–467. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Dlouhý P, Kucera P, Kraml P, Pompachová A, Potocková J, Smejkalová V, Mokrejs P, Jacek M and Andel M: Short-term dietary intake of C18:1 trans fatty acids decreases the function of cellular immunity in healthy young men. Ann Nutr Metab. 53:129–136. 2008. View Article : Google Scholar : PubMed/NCBI

29 

McCubrey JA, Abrams SL, Fitzgerald TL, Cocco L, Martelli AM, Montalto G, Cervello M, Scalisi A, Candido S, Libra M and Steelman LS: Roles of signaling pathways in drug resistance, cancer initiating cells and cancer progression and metastasis. Adv Biol Regul. 57:75–101. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Meng E, Mitra A, Tripathi K, Finan MA, Scalici J, McClellan S, da Silva L Madeira, Reed E, Shevde LA, Palle K and Rocconi RP: ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling. PLoS One. 9:e1071422014. View Article : Google Scholar : PubMed/NCBI

31 

Ren F, Sheng WQ and Du X: CD133: A cancer stem cells marker, is used in colorectal cancers. World J Gastroenterol. 19:2603–2611. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Sun Y, Kong W, Falk A, Hu J, Zhou L, Pollard S and Smith A: CD133 (Prominin) negative human neural stem cells are clonogenic and tripotent. PLoS One. 4:e54982009. View Article : Google Scholar : PubMed/NCBI

33 

Liu SJ, Cai ZW, Liu YJ, Dong MY, Sun LQ, Hu GF, Wei YY and Lao WD: Role of nucleostemin in growth regulation of gastric cancer, liver cancer and other malignancies. World J Gastroenterol. 10:1246–1249. 2004.PubMed/NCBI

34 

Haraguchi N, Inoue H, Tanaka F, Mimori K, Utsunomiya T, Sasaki A and Mori M: Cancer stem cells in human gastrointestinal cancers. Hum Cell. 19:24–29. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Kadochi Y, Mori S, Fujiwara R, Nishiguchi Y, Sasaki T, Sasaki T, et al: Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines. Oncol Lett 14: 681-686, 2017.
APA
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y. ... Kuniyasu, H. (2017). Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines. Oncology Letters, 14, 681-686. https://doi.org/10.3892/ol.2017.6190
MLA
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y., Mori, S., Fujiwara, R., Nishiguchi, Y., Sasaki, T., Kuniyasu, H."Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines". Oncology Letters 14.1 (2017): 681-686.
Chicago
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y., Mori, S., Fujiwara, R., Nishiguchi, Y., Sasaki, T., Kuniyasu, H."Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines". Oncology Letters 14, no. 1 (2017): 681-686. https://doi.org/10.3892/ol.2017.6190
Copy and paste a formatted citation
x
Spandidos Publications style
Tanabe E, Kitayoshi M, Fujii K, Ohmori H, Luo Y, Kadochi Y, Mori S, Fujiwara R, Nishiguchi Y, Sasaki T, Sasaki T, et al: Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines. Oncol Lett 14: 681-686, 2017.
APA
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y. ... Kuniyasu, H. (2017). Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines. Oncology Letters, 14, 681-686. https://doi.org/10.3892/ol.2017.6190
MLA
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y., Mori, S., Fujiwara, R., Nishiguchi, Y., Sasaki, T., Kuniyasu, H."Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines". Oncology Letters 14.1 (2017): 681-686.
Chicago
Tanabe, E., Kitayoshi, M., Fujii, K., Ohmori, H., Luo, Y., Kadochi, Y., Mori, S., Fujiwara, R., Nishiguchi, Y., Sasaki, T., Kuniyasu, H."Fatty acids inhibit anticancer effects of 5-fluorouracil in mouse cancer cell lines". Oncology Letters 14, no. 1 (2017): 681-686. https://doi.org/10.3892/ol.2017.6190
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