Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer

  • Authors:
    • Soo‑Jung Jung
    • Ji‑Hyoung Cho
    • Won‑Jin Park
    • Yu‑Ran Heo
    • Jae‑Ho Lee
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, School of Medicine, Keimyung University, Daegu, Republic of Korea, Department of General Surgery, School of Medicine, Keimyung University, Daegu, Republic of Korea
  • Pages: 925-929
    |
    Published online on: May 17, 2017
       https://doi.org/10.3892/ol.2017.6197
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

A positive correlation between telomere length and mitochondrial DNA (mtDNA) copy number has previously been observed in healthy individuals, and in patients with psychiatric disorders. In the present study, telomere length and mtDNA copy number were evaluated in gastric cancer (GC) tissue samples. DNA was extracted from 109 GC samples (including 82 intestinal, and 27 diffuse cases), and the telomere length and mtDNA copy number were analyzed using a quantitative‑polymerase chain reaction assay. The relative telomere length and mtDNA copy number in tumor tissue, as compared with in normal tissue, (mean ± standard deviation) in all GC samples were 11.48±1.14 and 14.86±1.35, respectively. Telomere length and mtDNA copy number were not identified as exhibiting clinical or prognostic value for GC. However, positive correlations between telomere length and mitochondrial DNA copy number were identified in GC (r=0.408, P<0.001) and in the adjacent normal mucosa (r=0.363; P<0.001). When stratified by Lauren classification, the correlation was identified in intestinal type GC samples (r=0.461; P<0.001), but not in diffuse type GC samples (r=0.225; P=0.260). This result indicated that loss of the correlation of telomeres and mitochondrial function may induce the initiation or progression of GC pathogenesis.
View Figures

Figure 1

Figure 2

View References

1 

Jung KW, Won YJ, Oh CM, Kong HJ, Cho H, Lee JK, Lee DH and Lee KH: Prediction of cancer incidence and mortality in Korea, 2016. Cancer Res Treat. 48:451–457. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Correa P and Shiao YH: Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res. 54 7 Suppl:1941s–1943s. 1994.PubMed/NCBI

3 

Grabsch HI and Tan P: Gastric cancer pathology and underlying molecular mechanisms. Dig Surg. 30:150–158. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Yakirevich E and Resnick MB: Pathology of gastric cancer and its precursor lesions. Gastroenterol Clin North Am. 42:261–284. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Akhavan-Niaki H and Samadani AA: Molecular insight in gastric cancer induction: An overview of cancer stemness genes. Cell Biochem Biophy. 68:463–473. 2014. View Article : Google Scholar

6 

Carcas LP: Gastric cancer review. J Carcinog. 13:142014. View Article : Google Scholar : PubMed/NCBI

7 

Harley CB, Futcher AB and Greider CW: Telomeres shorten during ageing of human fibroblasts. Nature. 345:458–460. 1990. View Article : Google Scholar : PubMed/NCBI

8 

Anderson S, Bankier AT, Barrell BG, De Bruijn MH, Coulson AR, Drouin J, Eperon IC, Nierlich DP, Roe BA, Sanger F, et al: Sequence and organization of the human mitochondrial genome. Nature. 290:457–465. 1981. View Article : Google Scholar : PubMed/NCBI

9 

Blackburn EH, Greider CW and Szostak JW: Telomeres and telomerase: The path from maize, Tetrahymena and yeast to human cancer and aging. Nat Med. 12:1133–1138. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Blasco MA: Telomeres and human disease: Ageing, cancer and beyond. Nat Rev Genet. 6:611–622. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Cui H, Huang P, Wang Z, Zhang Y, Zhang Z, Xu W, Wang X, Han Y and Guo X: Association of decreased mitochondrial DNA content with the progression of colorectal cancer. BMC Cancer. 13:1102013. View Article : Google Scholar : PubMed/NCBI

12 

Lee HC, Li SH, Lin JC, Wu CC, Yeh DC and Wei YH: Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. Mut Res. 547:71–78. 2004. View Article : Google Scholar

13 

Liao LM, Baccarelli A, Shu XO, Gao YT, Ji BT, Yang G, Li HL, Hoxha M, Dioni L, Rothman N, et al: Mitochondrial DNA copy number and risk of gastric cancer: A report from the Shanghai Women's Health Study. Cancer Epidemiol Biomarkers Prev. 20:1944–1949. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK and Spitz MR: Telomere dysfunction: A potential cancer predisposition factor. J Natl Cancer Inst. 95:1211–1218. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Kim JH, Kim HK, Ko JH, Bang H and Lee DC: The relationship between leukocyte mitochondrial DNA copy number and telomere length in community-dwelling elderly women. PloS one. 8:e672272013. View Article : Google Scholar : PubMed/NCBI

16 

Qiu C, Enquobahrie DA, Gelaye B, Hevner K and Williams MA: The association between leukocyte telomere length and mitochondrial DNA copy number in pregnant women: A pilot study. Clin Lab. 61:363–369. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Tyrka AR, Carpenter LL, Kao HT, Porton B, Philip NS, Ridout SJ, Ridout KK and Price LH: Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults. Exp Gerontol. 66:17–20. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Passos JF, Saretzki G and von Zglinicki T: DNA damage in telomeres and mitochondria during cellular senescence: Is there a connection? Nucleic Acids Res. 35:7505–7513. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, et al: Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 148:651–663. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, et al: Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 470:359–365. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Lee H, Lee JH, Kim DC, Hwang I, Kang YN, Gwon GJ, Choi IJ and Kim S: Is mitochondrial DNA copy number associated with clinical characteristics and prognosis in gastric cancer? Asian Pac J Cancer Prev. 16:87–90. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Lee H, Jin JD, La BM, Park WJ, Choi IJ and Lee JH: TERT promoter mutation, telomere length and TERT expression in gastric cancer. Int J Clin Exp Pathol. 9:1758–1763. 2016.

23 

Gil ME and Coetzer TL: Real-time quantitative PCR of telomere length. Mol Biotechnol. 27:169–172. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Lee JH, Hwang I, Kang YN, Choi IJ and Kim DK: Genetic characteristics of mitochondrial DNA was associated with colorectal carcinogenesis and its prognosis. PloS One. 10:e01186122015. View Article : Google Scholar : PubMed/NCBI

25 

Tyrka AR, Parade SH, Price LH, Kao HT, Porton B, Philip NS, Welch ES and Carpenter LL: Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology. Biol Psychiatry. 79:78–86. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Aslan R, Bektas A, Bedir A, Alacam H, Aslan MS, Nar R, Yildirim B, Goren I, Ecemis O, Ustaoglu M, et al: Helicobacter pylori eradication increases telomere length in gastric mucosa. Hepatogastroenterology. 60:601–604. 2013.PubMed/NCBI

27 

Pascua I, Fernández-Marcelo T, Sánchez-Pernaute A, De Juan C, Head J, Torres-García AJ and Iniesta P: Prognostic value of telomere function in gastric cancers with and without microsatellite instability. Eur J Gastroenterol Hepatol. 27:162–169. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Tahara T, Shibata T, Kawamura T, Ishizuka T, Okubo M, Nagasaka M, Nakagawa Y, Arisawa T, Ohmiya N and Hirata I: Telomere length in non-neoplastic gastric mucosa and its relationship to H. pylori infection, degree of gastritis and NSAID use. Clin Exp Med. 16:65–71. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Tahara T, Shibata T, Okubo M, Kawamura T, Horiguchi N, Ishizuka T, Nakani N, Nagasaka M, Nakagawa Y and Ohmiya N: Demonstration of potential link between helicobacter pylori related promoter CpG island methylation and telomere shortening in human gastric mucosa. Oncotarget. 7:43989–43996. 2016.PubMed/NCBI

30 

Jeong CW, Lee JH, Sohn SS, Ryu SW and Kim DK: Mitochondrial microsatellite instability in gastric cancer and gastric epithelial dysplasia as a precancerous lesion. Cancer Epidemiol. 34:323–327. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jung SJ, Cho JH, Park WJ, Heo YR and Lee JH: Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer. Oncol Lett 14: 925-929, 2017.
APA
Jung, S., Cho, J., Park, W., Heo, Y., & Lee, J. (2017). Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer. Oncology Letters, 14, 925-929. https://doi.org/10.3892/ol.2017.6197
MLA
Jung, S., Cho, J., Park, W., Heo, Y., Lee, J."Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer". Oncology Letters 14.1 (2017): 925-929.
Chicago
Jung, S., Cho, J., Park, W., Heo, Y., Lee, J."Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer". Oncology Letters 14, no. 1 (2017): 925-929. https://doi.org/10.3892/ol.2017.6197
Copy and paste a formatted citation
x
Spandidos Publications style
Jung SJ, Cho JH, Park WJ, Heo YR and Lee JH: Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer. Oncol Lett 14: 925-929, 2017.
APA
Jung, S., Cho, J., Park, W., Heo, Y., & Lee, J. (2017). Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer. Oncology Letters, 14, 925-929. https://doi.org/10.3892/ol.2017.6197
MLA
Jung, S., Cho, J., Park, W., Heo, Y., Lee, J."Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer". Oncology Letters 14.1 (2017): 925-929.
Chicago
Jung, S., Cho, J., Park, W., Heo, Y., Lee, J."Telomere length is correlated with mitochondrial DNA copy number in intestinal, but not diffuse, gastric cancer". Oncology Letters 14, no. 1 (2017): 925-929. https://doi.org/10.3892/ol.2017.6197
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team