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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Article

Antitumor effects of curcumin in human bladder cancer in vitro

  • Authors:
    • Jing Shi
    • Xu Zhang
    • Taoping Shi
    • Hongzhao Li
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China
  • Pages: 1157-1161
    |
    Published online on: May 18, 2017
       https://doi.org/10.3892/ol.2017.6205
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Abstract

Bladder cancer is one of the major causes of cancer‑associated mortality, with a high incidence. Curcumin, a polyphenol compound extracted from turmeric, has been identified to regulate tumor progression. However, the therapeutic effect of curcumin in human bladder cancer has not yet been determined. In the present study, the effects of curcumin on cell growth, apoptosis and migration of bladder cancer cell lines were evaluated using an MTT assay, a Transwell assay and flow cytometry, and the associated mechanisms were investigated using western blot analysis. Curcumin was identified to decrease the growth of T24 and 5637 cells in a dose‑ and time‑dependent manner. The present study confirmed that curcumin is able to inhibit cell migration and promote apoptosis of bladder cancer through suppression of matrix metalloproteinase signaling pathways in vitro. The anticancer effects of curcumin on bladder cancer cells may benefit clinical practice in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Shi J, Zhang X, Shi T and Li H: Antitumor effects of curcumin in human bladder cancer in vitro. Oncol Lett 14: 1157-1161, 2017.
APA
Shi, J., Zhang, X., Shi, T., & Li, H. (2017). Antitumor effects of curcumin in human bladder cancer in vitro. Oncology Letters, 14, 1157-1161. https://doi.org/10.3892/ol.2017.6205
MLA
Shi, J., Zhang, X., Shi, T., Li, H."Antitumor effects of curcumin in human bladder cancer in vitro". Oncology Letters 14.1 (2017): 1157-1161.
Chicago
Shi, J., Zhang, X., Shi, T., Li, H."Antitumor effects of curcumin in human bladder cancer in vitro". Oncology Letters 14, no. 1 (2017): 1157-1161. https://doi.org/10.3892/ol.2017.6205
Copy and paste a formatted citation
x
Spandidos Publications style
Shi J, Zhang X, Shi T and Li H: Antitumor effects of curcumin in human bladder cancer in vitro. Oncol Lett 14: 1157-1161, 2017.
APA
Shi, J., Zhang, X., Shi, T., & Li, H. (2017). Antitumor effects of curcumin in human bladder cancer in vitro. Oncology Letters, 14, 1157-1161. https://doi.org/10.3892/ol.2017.6205
MLA
Shi, J., Zhang, X., Shi, T., Li, H."Antitumor effects of curcumin in human bladder cancer in vitro". Oncology Letters 14.1 (2017): 1157-1161.
Chicago
Shi, J., Zhang, X., Shi, T., Li, H."Antitumor effects of curcumin in human bladder cancer in vitro". Oncology Letters 14, no. 1 (2017): 1157-1161. https://doi.org/10.3892/ol.2017.6205
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