Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2017 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Dermatofibrosarcoma protuberans of the breast: A case report

  • Authors:
    • Kamil Pohlodek
    • Iveta Mečiarová
    • Petr Grossmann
    • Zdeněk Kinkor
  • View Affiliations / Copyright

    Affiliations: The Second Department of Gynecology and Obstetrics, Faculty of Medicine, Comenius University of Bratislava, 82606 Bratislava, Slovakia, Alpha Medical Pathology, Ltd., 84101 Bratislava, Slovakia, Department of Pathology, Faculty of Medicine in Plzeň, Charles University in Prague, 32300 Plzeň, Czech Republic
    Copyright: © Pohlodek et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 993-998
    |
    Published online on: May 19, 2017
       https://doi.org/10.3892/ol.2017.6206
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumor of subcutaneous tissue characterized by slow infiltrative growth. The tumor occurs in patients of all ages, with the highest frequency occurring between the second and the fifth decades of age. Genetically, DFSP is characterized by a reciprocal translocation t(17;22)(q22;q13), or more often, as a supernumerary ring chromosome involving chromosomes 17 and 22. Standard treatment of a localized tumor is surgical excision with wide margins. In the present study, a case report of a 43‑year‑old woman with a growing tumor in the left breast is discussed. The patient underwent breast‑conserving surgery. Histological and cytogenetic examinations of the tumor resulted in a diagnosis of DFSP. The clinical and morphological characteristics of the tumor, in addition to the treatment options, were also evaluated.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Lemm D, Mügge LO, Mentzel T and Höffken K: Current treatment options in dermatofibrosarcoma protuberans. J Cancer Res Clin Oncol. 135:653–665. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Jiang J, Huang Z, Wang LH, Shen SD and Lu H: Dermatofibrosarcoma protuberans of the breast: A case report. Oncol Lett. 8:1202–1204. 2014.PubMed/NCBI

3 

Sin FN and Wong KW: Dermatofibrosarcoma protuberans of the breast: A case report. Clin Imaging. 35:398–400. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Criscione VD and Weinstock MA: Descriptive epidemiology of dermatofibrosarcoma protuberans in the United States, 1973 to 2002. J Am Acad Dermatol. 56:968–973. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Llombart B, Serra-Guillén C, Monteagudo C, López Guerrero JA and Sanmartín O: Dermatofibrosarcoma protuberans: A comprehensive review and update on diagnosis and management. Semin Diagn Pathol. 30:13–28. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Knutsvik G, Stefansson IM, Azis S, Arnes J, Eide J, Collett K and Akslen L: Evaluation of Ki67 expression across distinct categories of breast cancer specimens: A population-based study of matched surgical specimens, core needle biopsies and tissue microarrays. PLoS One. 9:e1121212014. View Article : Google Scholar : PubMed/NCBI

7 

Darier S and Ferrand M: Recurrent or progressive dermatofibromas and fibrosarcoma of the skin. Ann Dermatol Venerol. 5:545–562. 1924.(In French).

8 

Hoffman E: Ueber das knollentribende Fibrosarkom der Haut (dermatofibrosarcoma protuberans). Dermatol Z. 43:1–286. 1925.(In German). View Article : Google Scholar

9 

Taylor HB and Helwig EB: Dermatofibrosarcoma protuberans. A study of 115 cases. Cancer. 15:717–725. 1962. View Article : Google Scholar : PubMed/NCBI

10 

Chen X, Chen YH, Zhang YL, Guo YM, Bai ZL and Zhao X: Magnetic resonance imaging and mammographic appearance of dermatofibrosarcoma protuberans in a male breast: A case report and literature review. J Med Case Rep. 3:82462009. View Article : Google Scholar : PubMed/NCBI

11 

Serra-Guillén C, Sanmartín O, Llombart B, Nagore E, Deltoro C, Martín I, Borella-Estrada R, Requena C, Martorell-Calatayud A, Cervera J and Guillén C: Correlation between preoperative magnetic resonance imaging and surgical margins with modified Mohs for dermatofibrosarcoma protuberans. Dermatol Surg. 37:1638–1645. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Millare GG, Guha-Thakurta N, Sturgis EM, El-Naggar AK and Debnam JM: Imaging findings of head and neck dermatofibrosarcoma protuberans. AJNR Am J Neuroradiol. 35:373–378. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Zhang L, Liu QY, Cao Y, Zhong JS and Zhang WD: Dermatofibrosarcoma protuberans: Computed tomography and magnetic resonance imaging findings. Medicine (Baltimore). 94:e10012015. View Article : Google Scholar : PubMed/NCBI

14 

Chang GK, Jacobs IA and Salti GI: Outcomes of surgery for dermatofibrosarcoma protuberans. Eur J Surg Oncol. 30:341–345. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Li N, McNiff J, Hui P, Manfioletti G and Tallini G: Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: Potential diagnostic applications and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity. Am J Dermatopathol. 26:267–272. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Thway K, Ng W, Noujaim J, Jones RL and Fisher C: The current status of solitary fibrous tumor: Diagnostic features, variants and genetics. Int J Surg Pathol. 24:281–292. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Stacchiotti S, Pedeutour F, Negri T, Conca E, Marrari A, Palassini E, Collini P, Keslair F, Morosi C, Gronchi A, et al: Dermatofibrosarcoma protuberans-derived fibrosarcoma: Clinical history, biological profile and sensitivity to imatinib. Int J Cancer. 129:1761–1772. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Kuzel P, Mahmood MN, Metelitsa AI and Salopek TG: A clinicopathologic review of a case series of dermatofibrosarcoma protuberans with fibrosarcomatous differentiation. J Cutan Med Surg. 19:28–34. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Lim SZ, Ong KW, Tee Tan BK, Selvarajan S and Tan P Hoon: Sarcoma of the breast: An update on a rare entity. J Clin Pathol. 69:373–381. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Al Barwani AS, Taif S, Al Mazrouai RA, Al Muzahmi KS and Alrawi A: Dermatofibrosarcoma protuberans: Insights into a rare soft tissue tumor. J Clin Imaging Sci. 6:162016. View Article : Google Scholar : PubMed/NCBI

21 

Llombart B, Monteagudo C, Sanmartín O, López-Guerrero JA, Serra-Guillén C, Poveda A, Jorda E, Fernandez-Serra A, Pellín A, Guillén C and Llombart-Bosch A: Dermatofibrosarcoma protuberans: A clinicopathological, immunohistochemical, genetic (COL1A1-PDGFB), and therapeutic study of low-grade versus high-grade (fibrosarcomatous) tumors. J Am Acad Dermatol. 65:564–575. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Simon MP, Navarro M, Roux D and Pouysségur J: Structural and functional analysis of a chimeric protein COL1A1-PDGFB generated by the translocation t(17; 22)(q22;q13.1) in dematofibrosarcoma protubrans (DP). Oncogene. 20:2965–2975. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Giacchero D, Maire G, Nuin PA, Berthier F, Ebran N, Carlotti A, Celerier P, Coindre JM, Esteve E, Fraitag S, et al: No correlation between the molecular subtype of COL1A1-PDGFB fusion gene and the clinicohistopathological features of dermatofibrosarcoma protuberans. J Invest Dermatol. 130:904–907. 2010. View Article : Google Scholar : PubMed/NCBI

24 

McArthur GA, Demetri GD, van Oosterom A, Heinrich MC, Debiec-Rychter M, Corless CL, Nikolova Z, Dimitrijevic S and Fletcher JA: Molecular and clinical analysis of locally advanced dermatofibrosarcoma protuberans treated with imatinib: Imatinib target exploration consortium study B2225. J Clin Oncol. 23:866–873. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Snow SN, Gordon EM, Larson PO, Bagheri MM, Bentz ML and Sable DB: Dermatofibrosarcoma protuberans: A report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature. Cancer. 101:28–38. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Farma JM, Ammori JB, Zager JS, Marzban SS, Bui MM, Bichakjian CK, Johnson TM, Lowe L, Sabel MS, Wong SL, et al: Dermatofibrosarcoma protuberans: How wide should we resect? Ann Surg Oncol. 17:2112–2118. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Fields RC, Hameed M, Qin LX, Moraco N, Jia X, Maki RG, Singer S and Brennan MF: Dermatofibrosarcoma protuberans (DFSP): Predictors of recurrence and the use of systemic therapy. Ann Surg Oncol. 18:328–336. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Williams N, Morris CG, Kirwan JM, Dagan R and Mendenhall WM: Radiotherapy for dermatofibrosarcoma protuberans. Am J Clin Oncol. 37:430–432. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Eilers G, Czaplinski JT, Mayeda M, Bahri N, Tao D, Zhu M, Hornick JL, Lindeman NI, Sicinska E, Wagner AJ, et al: CDKN2A/p16 Loss implicates CDK4 as a therapeutic target in imatinib-resistant dermatofibrosarcoma protuberans. Mol Cancer Ther. 14:1346–1353. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Pohlodek K, Mečiarová I, Grossmann P and Kinkor Z: Dermatofibrosarcoma protuberans of the breast: A case report . Oncol Lett 14: 993-998, 2017.
APA
Pohlodek, K., Mečiarová, I., Grossmann, P., & Kinkor, Z. (2017). Dermatofibrosarcoma protuberans of the breast: A case report . Oncology Letters, 14, 993-998. https://doi.org/10.3892/ol.2017.6206
MLA
Pohlodek, K., Mečiarová, I., Grossmann, P., Kinkor, Z."Dermatofibrosarcoma protuberans of the breast: A case report ". Oncology Letters 14.1 (2017): 993-998.
Chicago
Pohlodek, K., Mečiarová, I., Grossmann, P., Kinkor, Z."Dermatofibrosarcoma protuberans of the breast: A case report ". Oncology Letters 14, no. 1 (2017): 993-998. https://doi.org/10.3892/ol.2017.6206
Copy and paste a formatted citation
x
Spandidos Publications style
Pohlodek K, Mečiarová I, Grossmann P and Kinkor Z: Dermatofibrosarcoma protuberans of the breast: A case report . Oncol Lett 14: 993-998, 2017.
APA
Pohlodek, K., Mečiarová, I., Grossmann, P., & Kinkor, Z. (2017). Dermatofibrosarcoma protuberans of the breast: A case report . Oncology Letters, 14, 993-998. https://doi.org/10.3892/ol.2017.6206
MLA
Pohlodek, K., Mečiarová, I., Grossmann, P., Kinkor, Z."Dermatofibrosarcoma protuberans of the breast: A case report ". Oncology Letters 14.1 (2017): 993-998.
Chicago
Pohlodek, K., Mečiarová, I., Grossmann, P., Kinkor, Z."Dermatofibrosarcoma protuberans of the breast: A case report ". Oncology Letters 14, no. 1 (2017): 993-998. https://doi.org/10.3892/ol.2017.6206
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team