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Article Open Access

MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF

Retraction in: /10.3892/ol.2024.14597
  • Authors:
    • Rongrong Song
    • Lin Cong
    • Guantai Ni
    • Min Chen
    • Honmei Sun
    • Yunxia Sun
    • Meiling Chen
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China, Department of Obstetrics and Gynecology, The People's Hospital of Xuancheng, Xuancheng, Anhui 242000, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 767-775
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    Published online on: May 19, 2017
       https://doi.org/10.3892/ol.2017.6210
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Abstract

MicroRNAs (miRNAs/miRs) are a class of conserved non‑coding endogenous small regulatory RNAs that regulate target gene expression by binding to the 3'‑untranslated region of target mRNAs in a base‑pairing manner, resulting in repression of transcription or degradation of target mRNAs. It has been demonstrated previously that the abnormal expression of miRNAs is involved in the carcinogenesis and progression of cervical cancer. The aim of the present study was to investigate the expression, biological functions and underlying molecular mechanisms of miR‑195 in cervical cancer. The reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect the expression level of miR‑195 in cervical cancer tissues and cell lines. Following transfection, an MTT assay, cell migration and invasion assays, western blot analysis and a dual‑luciferase reporter assay were performed in human cervical cancer cells. In the present study, it was identified that miR‑195 was downregulated in cervical cancer tissues and cell lines. Additionally, upregulation of miR‑195 and knockdown of hepatoma‑derived growth factor (HDGF) inhibited proliferation, migration and invasion of cervical cancer cells. Furthermore, a dual‑luciferase reporter assay identified that HDGF was a direct target gene of miR‑195. RT‑qPCR and western blot analysis demonstrated that miR‑195 mimic inhibited HDGF expression at the mRNA and protein levels, whereas miR‑195 inhibitor enhanced HDGF expression at the mRNA and protein levels. These results indicated that miR‑195 targeted HDGF to inhibit the behavior of tumors in cervical cancer. These results also suggested that miR‑195 was a potential therapeutic biomarker of cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Song R, Cong L, Ni G, Chen M, Sun H, Sun Y and Chen M: MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF Retraction in /10.3892/ol.2024.14597. Oncol Lett 14: 767-775, 2017.
APA
Song, R., Cong, L., Ni, G., Chen, M., Sun, H., Sun, Y., & Chen, M. (2017). MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF Retraction in /10.3892/ol.2024.14597. Oncology Letters, 14, 767-775. https://doi.org/10.3892/ol.2017.6210
MLA
Song, R., Cong, L., Ni, G., Chen, M., Sun, H., Sun, Y., Chen, M."MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF Retraction in /10.3892/ol.2024.14597". Oncology Letters 14.1 (2017): 767-775.
Chicago
Song, R., Cong, L., Ni, G., Chen, M., Sun, H., Sun, Y., Chen, M."MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF Retraction in /10.3892/ol.2024.14597". Oncology Letters 14, no. 1 (2017): 767-775. https://doi.org/10.3892/ol.2017.6210
Copy and paste a formatted citation
x
Spandidos Publications style
Song R, Cong L, Ni G, Chen M, Sun H, Sun Y and Chen M: MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF Retraction in /10.3892/ol.2024.14597. Oncol Lett 14: 767-775, 2017.
APA
Song, R., Cong, L., Ni, G., Chen, M., Sun, H., Sun, Y., & Chen, M. (2017). MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF Retraction in /10.3892/ol.2024.14597. Oncology Letters, 14, 767-775. https://doi.org/10.3892/ol.2017.6210
MLA
Song, R., Cong, L., Ni, G., Chen, M., Sun, H., Sun, Y., Chen, M."MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF Retraction in /10.3892/ol.2024.14597". Oncology Letters 14.1 (2017): 767-775.
Chicago
Song, R., Cong, L., Ni, G., Chen, M., Sun, H., Sun, Y., Chen, M."MicroRNA-195 inhibits the behavior of cervical cancer tumors by directly targeting HDGF Retraction in /10.3892/ol.2024.14597". Oncology Letters 14, no. 1 (2017): 767-775. https://doi.org/10.3892/ol.2017.6210
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