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Article

UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer

  • Authors:
    • Kenji Imai
    • Takeshi Fukuda
    • Takuma Wada
    • Masaru Kawanishi
    • Reiko Tasaka
    • Tomoyo Yasui
    • Toshiyuki Sumi
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan
  • Pages: 951-957
    |
    Published online on: May 19, 2017
       https://doi.org/10.3892/ol.2017.6212
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Abstract

Concurrent chemoradiotherapy is the standard treatment for locally advanced uterine cervical cancer. However, effective neoadjuvant chemotherapy (NAC) can reduce tumor size and facilitate hysterectomy for locally advanced uterine cervical cancer. NAC treatment could improve the prognosis of patients with locally advanced cervical cancer. However, if NAC is ineffective, radiotherapy must be pursued. This causes a delay in initiating the core treatment and results in a worse prognosis. Therefore, the identification of predictive markers of whether NAC is likely to be effective for the treatment of locally advanced uterine cervical cancer could improve patient prognosis. Uncoupling protein 2 (UCP2) is broadly expressed in cancer cells, and suppresses mitochondrial reactive oxygen species (ROS) production. UCP2 contributes to both carcinogenesis and chemoresistance by reducing ROS. Downregulation of UCP2 results in significantly increased cell death following chemotherapy. The present study investigated the association between UCP2 expression and NAC effectiveness. A total of 58 patients with locally advanced uterine cervical cancer (stage IIIA or IIIB) treated at Osaka City University Hospital between April 1995 and March 2010 were examined. Tumor tissue samples were obtained by punch biopsy prior to NAC. UCP2 expression was examined immunohistochemically and scored using a weighted scoring system. Patients were divided into NAC effective (n=34) and ineffective (n=24) groups. Furthermore, UCP2 expression in human uterine cervical cancer cells was inhibited by genipin, and changes in cisplatin sensitivity were examined. UCP2 weighted score was higher in the NAC ineffective group than in the NAC effective group (P=0.038). Additionally, the low UCP2 expression group was more sensitive to NAC than the high UCP2 expression group (P=0.041). Sensitivity to cisplatin was significantly increased when UCP2 was inhibited in human uterine cervical cancer cells in vitro. UCP2 expression may become a predictive marker of whether NAC is effective for patients with locally advanced uterine cervical cancer, which could improve patient prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Imai K, Fukuda T, Wada T, Kawanishi M, Tasaka R, Yasui T and Sumi T: UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer. Oncol Lett 14: 951-957, 2017.
APA
Imai, K., Fukuda, T., Wada, T., Kawanishi, M., Tasaka, R., Yasui, T., & Sumi, T. (2017). UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer. Oncology Letters, 14, 951-957. https://doi.org/10.3892/ol.2017.6212
MLA
Imai, K., Fukuda, T., Wada, T., Kawanishi, M., Tasaka, R., Yasui, T., Sumi, T."UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer". Oncology Letters 14.1 (2017): 951-957.
Chicago
Imai, K., Fukuda, T., Wada, T., Kawanishi, M., Tasaka, R., Yasui, T., Sumi, T."UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer". Oncology Letters 14, no. 1 (2017): 951-957. https://doi.org/10.3892/ol.2017.6212
Copy and paste a formatted citation
x
Spandidos Publications style
Imai K, Fukuda T, Wada T, Kawanishi M, Tasaka R, Yasui T and Sumi T: UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer. Oncol Lett 14: 951-957, 2017.
APA
Imai, K., Fukuda, T., Wada, T., Kawanishi, M., Tasaka, R., Yasui, T., & Sumi, T. (2017). UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer. Oncology Letters, 14, 951-957. https://doi.org/10.3892/ol.2017.6212
MLA
Imai, K., Fukuda, T., Wada, T., Kawanishi, M., Tasaka, R., Yasui, T., Sumi, T."UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer". Oncology Letters 14.1 (2017): 951-957.
Chicago
Imai, K., Fukuda, T., Wada, T., Kawanishi, M., Tasaka, R., Yasui, T., Sumi, T."UCP2 expression may represent a predictive marker of neoadjuvant chemotherapy effectiveness for locally advanced uterine cervical cancer". Oncology Letters 14, no. 1 (2017): 951-957. https://doi.org/10.3892/ol.2017.6212
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