β-human chorionic gonadotropin-secreting intracranial germ-cell tumor associated with high testosterone in an adult man: 
A case report

Yang,Wen‑Ping; Chien,Hung‑Yu; Lin,Yi‑Chun

doi:10.3892/ol.2017.6213

July-2017 Volume 14 Issue 1

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July-2017 Volume 14 Issue 1

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Case Report

β-human chorionic gonadotropin-secreting intracranial germ-cell tumor associated with high testosterone in an adult man: A case report

Authors:
- Wen‑Ping Yang
- Hung‑Yu Chien
- Yi‑Chun Lin
View Affiliations / Copyright

Affiliations: Section of Endocrinology and Metabolism, Department of Medicine, Taipei City Hospital Ren‑Ai Branch, Taipei 106, Taiwan, R.O.C., Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei 112, Taiwan, R.O.C.
Pages: 1129-1132
|
Published online on: May 19, 2017

https://doi.org/10.3892/ol.2017.6213
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Abstract

A 38-year-old male patient presented with general weakness, polydipsia and a body weight loss of 10 kg in two years. Hypopituitarism with central hypothyroidism and central adrenal insufficiency were noted at Taipei City Hospital (Taipei, Taiwan). However, hypogonadotropic hypergonadism was also observed. The patient was diagnosed with an intracranial β‑human chorionic gonadotropin (β‑hCG) secreting germ‑cell tumor, and brain magnetic resonance imaging revealed that the tumor involved the pineal gland, stalk, posterior pituitary gland, right basal ganglion, hypothalamus, corpus callosum and posterior hippocampus. The cerebrospinal fluid (CSF) β‑hCG level was 1936 IU/l, while the α-fetoprotein (AFP) level was <0.24 ng/ml. The serum AFP level of the patient was 3.28 ng/ml, and the β‑hCG level was 178 IU/l with a CSF:serum β‑hCG ratio >2:1. The patient was successfully treated with chemotherapy and radiotherapy, as demonstrated by a marked decrease in size of the tumor and in the serum β‑hCG levels. Intracranial β‑hCG secreting germ‑cell tumors are rare in adults and manifest differently compared with patients of early pubertal age. In contrast with the precocious puberty frequently observed in young patients, the diagnosis of adult patients is often delayed and the symptoms are associated with tumor size and location. The present case report described an adult male with an intracranial β‑hCG secreting GCT, demonstrating hypopituitarism and asymptomatic hyperandrogenemia, and reviews and discusses the literature relevant to the case.

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