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Article

Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics

  • Authors:
    • Haipeng Wang
    • Shengjian Jin
    • Huiling Lu
    • Sisi Mi
    • Wenhua Shao
    • Xiaoxv Zuo
    • Huangyi Yin
    • Sien Zeng
    • Fumio Shimamoto
    • Guangying Qi
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Guilin Medical College, Guilin, Guangxi 541199, P.R. China, Department of Pathology and Physiopathology, Guilin Medical University, Guilin, Guangxi 541004, P.R. China, Department of Health Sciences, Prefectural University of Hiroshima, Hiroshima 734‑8558, Japan
  • Pages: 1011-1016
    |
    Published online on: May 19, 2017
       https://doi.org/10.3892/ol.2017.6218
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Abstract

Survivin is a bifunctional protein that suppresses apoptosis and regulates cell division, and is highly expressed in various cancer types. Mucins are high‑molecular‑weight, heavily glycosylated proteins. In the present study, the association between survivin, mucin 2 (MUC2) and MUC5 expression, and the clinicopathological features of colorectal cancer (CRC) were investigated. The immunohistochemistry and western blotting results demonstrated that survivin was highly expressed in CRC tissues and rarely expressed in normal colon tissues. Moreover, the overexpression of survivin and MUC5 was strongly associated with lymph node metastasis, poor cellular differentiation, advanced tumor stage and a poor prognosis in CRC. By contrast, low expression of MUC2 was significantly associated with lymph node metastasis, poor cellular differentiation and an advanced tumor stage in CRC. The results of the present study suggest that survivin, MUC2 and MUC5 levels may be associated with tumor progression and could be used to aid the early diagnosis and clinical characterization of CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Jin S, Lu H, Mi S, Shao W, Zuo X, Yin H, Zeng S, Shimamoto F, Qi G, Qi G, et al: Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics. Oncol Lett 14: 1011-1016, 2017.
APA
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X. ... Qi, G. (2017). Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics. Oncology Letters, 14, 1011-1016. https://doi.org/10.3892/ol.2017.6218
MLA
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X., Yin, H., Zeng, S., Shimamoto, F., Qi, G."Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics". Oncology Letters 14.1 (2017): 1011-1016.
Chicago
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X., Yin, H., Zeng, S., Shimamoto, F., Qi, G."Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics". Oncology Letters 14, no. 1 (2017): 1011-1016. https://doi.org/10.3892/ol.2017.6218
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Jin S, Lu H, Mi S, Shao W, Zuo X, Yin H, Zeng S, Shimamoto F, Qi G, Qi G, et al: Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics. Oncol Lett 14: 1011-1016, 2017.
APA
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X. ... Qi, G. (2017). Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics. Oncology Letters, 14, 1011-1016. https://doi.org/10.3892/ol.2017.6218
MLA
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X., Yin, H., Zeng, S., Shimamoto, F., Qi, G."Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics". Oncology Letters 14.1 (2017): 1011-1016.
Chicago
Wang, H., Jin, S., Lu, H., Mi, S., Shao, W., Zuo, X., Yin, H., Zeng, S., Shimamoto, F., Qi, G."Expression of survivin, MUC2 and MUC5 in colorectal cancer and their association with clinicopathological characteristics". Oncology Letters 14, no. 1 (2017): 1011-1016. https://doi.org/10.3892/ol.2017.6218
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