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Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis

  • Authors:
    • Chanitra Thuwajit
    • Peti Thuwajit
    • Pranisa Jamjantra
    • Chawalit Pairojkul
    • Sopit Wongkham
    • Vajarabhongsa Bhudhisawasdi
    • Junya Ono
    • Shoichiro Ohta
    • Kiminori Fujimoto
    • Kenji Izuhara
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok‑Noi, Bangkok 10700, Thailand, Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Khon Kaen 40002, Thailand, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Khon Kaen 40002, Thailand, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Khon Kaen 40002, Thailand, Research and Development Unit, Shino‑Test Corporation, Minami‑Ku, Sagamihara, Kanagawa 252‑0331, Japan, Department of Biomolecular Sciences, Saga Medical School, Saga 849‑8501, Japan, Department of Radiology, Kurume University School of Medicine and Center for Diagnostic Imaging, Kurume University Hospital, Kurume, Fukuoka 830‑0011, Japan
    Copyright: © Thuwajit et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 623-634
    |
    Published online on: May 25, 2017
       https://doi.org/10.3892/ol.2017.6250
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Abstract

An effective serum biomarker may improve cholangiocarcinoma (CCA) management. Periostin (PN) has been demonstrated to be associated with aggressive CCA. The current study evaluated PN in blood serum for its diagnostic and prognostic potential in patients with CCA. Sera of 68 patients with CCA were collected prior to treatment, and PN levels were measured using an ELISA. Sera from 50 normal controls, 6 patients with benign liver diseases, 2 with hepatocellular carcinoma and 21 with breast cancer were analyzed. Immunohistochemistry of PN in CCA tissues was also investigated. The data were analyzed using the Mann‑Whitney U test, Kaplan‑Meier log rank tests, Cox proportional hazard regression models and Fisher's exact tests. The median serum PN level in patients with CCA was significantly increased compared with that in healthy controls, patients with benign liver diseases and patients with breast cancer (all P<0.05). Using an optimal threshold value of 94 ng/ml PN, the diagnostic values for CCA compared with other conditions demonstrated a sensitivity level of 0.38 [95% confidence interval (CI), 0.27‑0.51], specificity of 0.90 (95% CI, 0.81‑0.96), accuracy of 0.66 (95% CI, 0.58‑0.74), positive predictive value of 0.76 (95% CI, 0.59‑0.89) and negative predictive value of 0.63 (95% CI, 0.53‑0.72) (P<0.001). Furthermore, PN stain in stromal fibroblasts in CCA tissues was associated with serum PN levels (P=0.001), and patients with CCA were classified as low (≤94 ng/ml) or high PN (>94 ng/ml) accordingly. High serum and tissue PN levels were significantly associated with reduced survival rate (P<0.001 and P=0.033, respectively). Serum PN was an independent prognostic factor with a hazard ratio of 3.197 (P=0.001). In conclusion, serum PN may be used to divide patients with intrahepatic CCA into high and low PN groups. Elevated serum PN may be utilized as a marker of poor prognosis in patients with CCA.
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Copy and paste a formatted citation
Spandidos Publications style
Thuwajit C, Thuwajit P, Jamjantra P, Pairojkul C, Wongkham S, Bhudhisawasdi V, Ono J, Ohta S, Fujimoto K, Izuhara K, Izuhara K, et al: Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis. Oncol Lett 14: 623-634, 2017.
APA
Thuwajit, C., Thuwajit, P., Jamjantra, P., Pairojkul, C., Wongkham, S., Bhudhisawasdi, V. ... Izuhara, K. (2017). Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis. Oncology Letters, 14, 623-634. https://doi.org/10.3892/ol.2017.6250
MLA
Thuwajit, C., Thuwajit, P., Jamjantra, P., Pairojkul, C., Wongkham, S., Bhudhisawasdi, V., Ono, J., Ohta, S., Fujimoto, K., Izuhara, K."Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis". Oncology Letters 14.1 (2017): 623-634.
Chicago
Thuwajit, C., Thuwajit, P., Jamjantra, P., Pairojkul, C., Wongkham, S., Bhudhisawasdi, V., Ono, J., Ohta, S., Fujimoto, K., Izuhara, K."Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis". Oncology Letters 14, no. 1 (2017): 623-634. https://doi.org/10.3892/ol.2017.6250
Copy and paste a formatted citation
x
Spandidos Publications style
Thuwajit C, Thuwajit P, Jamjantra P, Pairojkul C, Wongkham S, Bhudhisawasdi V, Ono J, Ohta S, Fujimoto K, Izuhara K, Izuhara K, et al: Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis. Oncol Lett 14: 623-634, 2017.
APA
Thuwajit, C., Thuwajit, P., Jamjantra, P., Pairojkul, C., Wongkham, S., Bhudhisawasdi, V. ... Izuhara, K. (2017). Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis. Oncology Letters, 14, 623-634. https://doi.org/10.3892/ol.2017.6250
MLA
Thuwajit, C., Thuwajit, P., Jamjantra, P., Pairojkul, C., Wongkham, S., Bhudhisawasdi, V., Ono, J., Ohta, S., Fujimoto, K., Izuhara, K."Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis". Oncology Letters 14.1 (2017): 623-634.
Chicago
Thuwajit, C., Thuwajit, P., Jamjantra, P., Pairojkul, C., Wongkham, S., Bhudhisawasdi, V., Ono, J., Ohta, S., Fujimoto, K., Izuhara, K."Clustering of patients with intrahepatic cholangiocarcinoma based on serum periostin may be predictive of prognosis". Oncology Letters 14, no. 1 (2017): 623-634. https://doi.org/10.3892/ol.2017.6250
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