Bevacizumab as a last-line treatment for glioblastoma following failure of radiotherapy, temozolomide and lomustine

  • Authors:
    • Katharina J. Wenger
    • Marlies Wagner
    • Se‑Jong You
    • Kea Franz
    • Patrick N. Harter
    • Michael C. Burger
    • Martin Voss
    • Michael W. Ronellenfitsch
    • Emmanouil Fokas
    • Joachim P. Steinbach
    • Oliver Bähr
  • View Affiliations

  • Published online on: May 25, 2017     https://doi.org/10.3892/ol.2017.6251
  • Pages: 1141-1146
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Abstract

In previous trials, bevacizumab failed to prolong the overall survival time in newly diagnosed glioblastoma and at the first recurrence. Randomized clinical trials at the second or further recurrence following the failure of radiotherapy, temozolomide and lomustine, and retrospective analyses focusing on this specific cohort, are not yet available. A total of 62 patients with glioblastoma who received bevacizumab after the failure of standard care, including radiotherapy, temozolomide and lomustine, were retrospectively identified. Patient characteristics, previous treatment details, concomitant therapy, response based on the Response Assessment in Neuro‑Oncology criteria, and progression‑free survival (PFS) and overall survival (OS) times and rates were evaluated. Furthermore, the PFS and OS times and rates were analyzed for responders and non‑responders. Of the patients, 54.8% (n=34) responded to treatment [complete response (CR) 3.2%, n=2; partial response (PR) 51.6%, n=32]. The median PFS time was 3.5 months and the median OS time was 7.5 months. The PFS rate at 6 months was 21.5% and the OS rate at 12 months was 11.5%. Responders (CR or PR) experienced a superior median PFS time compared with non‑responders (i.e. stable or progressive disease; 5.4 vs. 1.9 months; P<0.0001) and a superior PFS rate at 6 months (34.9 vs. 7.1%; P<0.0001). The median OS time (8.6 vs. 6.4 months; P<0.0001) and OS rate at 12 months (21.3 vs. 0%; P<0.0001) were also superior in patients who exhibited a response to bevacizumab treatment. In conclusion, the objective response rate and the PFS and OS times and rates indicate that bevacizumab has activity in patients with glioblastoma following the failure of radiotherapy, temozolomide, and lomustine. A randomized trial comparing bevacizumab with best supportive care in these patients is advised.
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July-2017
Volume 14 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wenger KJ, Wagner M, You SJ, Franz K, Harter PN, Burger MC, Voss M, Ronellenfitsch MW, Fokas E, Steinbach JP, Steinbach JP, et al: Bevacizumab as a last-line treatment for glioblastoma following failure of radiotherapy, temozolomide and lomustine. Oncol Lett 14: 1141-1146, 2017
APA
Wenger, K.J., Wagner, M., You, S., Franz, K., Harter, P.N., Burger, M.C. ... Bähr, O. (2017). Bevacizumab as a last-line treatment for glioblastoma following failure of radiotherapy, temozolomide and lomustine. Oncology Letters, 14, 1141-1146. https://doi.org/10.3892/ol.2017.6251
MLA
Wenger, K. J., Wagner, M., You, S., Franz, K., Harter, P. N., Burger, M. C., Voss, M., Ronellenfitsch, M. W., Fokas, E., Steinbach, J. P., Bähr, O."Bevacizumab as a last-line treatment for glioblastoma following failure of radiotherapy, temozolomide and lomustine". Oncology Letters 14.1 (2017): 1141-1146.
Chicago
Wenger, K. J., Wagner, M., You, S., Franz, K., Harter, P. N., Burger, M. C., Voss, M., Ronellenfitsch, M. W., Fokas, E., Steinbach, J. P., Bähr, O."Bevacizumab as a last-line treatment for glioblastoma following failure of radiotherapy, temozolomide and lomustine". Oncology Letters 14, no. 1 (2017): 1141-1146. https://doi.org/10.3892/ol.2017.6251