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Article

Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI

  • Authors:
    • Shuri Aoki
    • Tomonori Kanda
    • Noriyuki Matsutani
    • Nobuhiko Seki
    • Masafumi Kawamura
    • Shigeru Furui
    • Hideomi Yamashita
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Teikyo University School of Medicine, Itabashi‑ku, Tokyo 173‑8605, Japan, Department of General Thoracic Surgery, Teikyo University School of Medicine, Itabashi‑ku, Tokyo 173‑8605, Japan, Department of Medical Oncology, Teikyo University School of Medicine, Itabashi‑ku, Tokyo 173‑8605, Japan, Department of Radiology, University of Tokyo Hospital, Bunkyo‑ku, Tokyo 113‑8655, Japan
  • Pages: 1073-1079
    |
    Published online on: May 26, 2017
       https://doi.org/10.3892/ol.2017.6264
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Abstract

Previous studies have been conducted on the prognostic factors for overall survival in patients with brain metastases (BMs) following whole brain radiotherapy (WBRT). However, there have been a small number of studies regarding the prognostic factors for the response of tumor to WBRT. The aim of the present study was to identify the predictive factors for the response to WBRT from the point of view of reduction of tumor using magnetic resonance imaging. A retrospective analysis of 62 patients with BMs from primary lung cancer treated with WBRT was undertaken. The effects of the following factors on the response to WBRT were evaluated: Age; sex; performance status; lactate dehydrogenase; pathology; existence of extracranial metastases; activity of extracranial disease; chemo‑history; chest radiotherapy history; treatment term; γ‑knife radiotherapy; diffusion weighted image signal intensity; tumor diameter; extent of edema and the edema/tumor (E/T) ratio. The association between the reduction of tumors and clinical factors was evaluated using logistic regression analysis. P<0.05 was considered to indicate a statistically significant difference. The overall response ratio of this cohort was 54.8%. In the univariate analysis, the response of tumors was associated with the presence of small cell lung carcinoma (SCLC; P=0.0007), an E/T ratio of ≥1.5 (P=0.048), and a median tumor diameter of <20 mm (P=0.014). In the multivariate analysis, the presence of SCLC [P=0.001; odds ratio (OR), 17.152), an E/T ratio of ≥1.5 (P=0.019; OR, 9.526), and the presence of extracranial metastases (P=0.031; OR, 4.875) were revealed to be independent predictive factors for the reduction of tumor. The following 3 factors were significantly associated with the response of tumors to WBRT: The presence of SCLC; an E/T ratio of ≥1.5; and the presence of extracranial metastases. The E/T ratio is a novel index that provides a simple and easy predictive method for use in a clinical setting.
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Copy and paste a formatted citation
Spandidos Publications style
Aoki S, Kanda T, Matsutani N, Seki N, Kawamura M, Furui S and Yamashita H: Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI. Oncol Lett 14: 1073-1079, 2017.
APA
Aoki, S., Kanda, T., Matsutani, N., Seki, N., Kawamura, M., Furui, S., & Yamashita, H. (2017). Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI. Oncology Letters, 14, 1073-1079. https://doi.org/10.3892/ol.2017.6264
MLA
Aoki, S., Kanda, T., Matsutani, N., Seki, N., Kawamura, M., Furui, S., Yamashita, H."Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI". Oncology Letters 14.1 (2017): 1073-1079.
Chicago
Aoki, S., Kanda, T., Matsutani, N., Seki, N., Kawamura, M., Furui, S., Yamashita, H."Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI". Oncology Letters 14, no. 1 (2017): 1073-1079. https://doi.org/10.3892/ol.2017.6264
Copy and paste a formatted citation
x
Spandidos Publications style
Aoki S, Kanda T, Matsutani N, Seki N, Kawamura M, Furui S and Yamashita H: Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI. Oncol Lett 14: 1073-1079, 2017.
APA
Aoki, S., Kanda, T., Matsutani, N., Seki, N., Kawamura, M., Furui, S., & Yamashita, H. (2017). Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI. Oncology Letters, 14, 1073-1079. https://doi.org/10.3892/ol.2017.6264
MLA
Aoki, S., Kanda, T., Matsutani, N., Seki, N., Kawamura, M., Furui, S., Yamashita, H."Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI". Oncology Letters 14.1 (2017): 1073-1079.
Chicago
Aoki, S., Kanda, T., Matsutani, N., Seki, N., Kawamura, M., Furui, S., Yamashita, H."Examination of the predictive factors of the response to whole brain radiotherapy for brain metastases from lung cancer using MRI". Oncology Letters 14, no. 1 (2017): 1073-1079. https://doi.org/10.3892/ol.2017.6264
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