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Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer

  • Authors:
    • Maosong Lin
    • Bensong Duan
    • Jiangfeng Hu
    • Hong Yu
    • Haihui Sheng
    • Hengjun Gao
    • Junxing Huang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China, Department of Pathology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China, CMC Biobank and Translational Medicine Institute, Taizhou, Jiangsu 225312, P.R. China, Department of Oncology, Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1061-1067
    |
    Published online on: May 26, 2017
       https://doi.org/10.3892/ol.2017.6266
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Abstract

Epithelial-mesenchymal transition (EMT) is an early and key process in the metastatic cascade during the progression of colorectal cancer (CRC). The aim of the present study was to identify deregulated EMT‑related microRNAs (miRNAs/miRs) of CRC and assess the effect of differentially expressed miRNAs on the prognosis of patients with CRC. Genome‑wide expression profiling of miRNAs was assessed in 3 EMT‑negative and 3 EMT‑positive CRC tissues. Differentially expressed miRNA was further validated in 90 pairs of CRC and corresponding paracarcinoma tissues using the reverse transcription-quantitative polymerase chain reaction (RT‑qPCR). A total of 6 miRNAs (miR‑10a‑5p miR‑204‑3p, miR‑1224‑3p, miR‑193a‑3p, miR‑365a‑3p and miR‑3678‑3p) were identified to be differentially expressed between different EMT statuses of CRC tissues. Following validation using RT‑qPCR, 3 miRNAs (miR‑10a‑5p, miR‑365a‑3p and miR‑193a‑3p) were selected for subsequent studies. The expression levels of miR‑10a‑5p, miR‑193a‑3p and miR‑365a‑3p were markedly increased compared with levels in corresponding paracarcinoma tissues. Survival analyses revealed that down‑regulation of miR‑193a‑3p was associated with worse prognosis of patients with CRC, particularly in female and older patients. The results of the present study indicate that miR‑193a‑3p may be an EMT‑related biomarker and serve as a novel prognostic factor for CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Lin M, Duan B, Hu J, Yu H, Sheng H, Gao H and Huang J: Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer. Oncol Lett 14: 1061-1067, 2017.
APA
Lin, M., Duan, B., Hu, J., Yu, H., Sheng, H., Gao, H., & Huang, J. (2017). Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer. Oncology Letters, 14, 1061-1067. https://doi.org/10.3892/ol.2017.6266
MLA
Lin, M., Duan, B., Hu, J., Yu, H., Sheng, H., Gao, H., Huang, J."Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer". Oncology Letters 14.1 (2017): 1061-1067.
Chicago
Lin, M., Duan, B., Hu, J., Yu, H., Sheng, H., Gao, H., Huang, J."Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer". Oncology Letters 14, no. 1 (2017): 1061-1067. https://doi.org/10.3892/ol.2017.6266
Copy and paste a formatted citation
x
Spandidos Publications style
Lin M, Duan B, Hu J, Yu H, Sheng H, Gao H and Huang J: Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer. Oncol Lett 14: 1061-1067, 2017.
APA
Lin, M., Duan, B., Hu, J., Yu, H., Sheng, H., Gao, H., & Huang, J. (2017). Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer. Oncology Letters, 14, 1061-1067. https://doi.org/10.3892/ol.2017.6266
MLA
Lin, M., Duan, B., Hu, J., Yu, H., Sheng, H., Gao, H., Huang, J."Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer". Oncology Letters 14.1 (2017): 1061-1067.
Chicago
Lin, M., Duan, B., Hu, J., Yu, H., Sheng, H., Gao, H., Huang, J."Decreased expression of miR-193a-3p is associated with poor prognosis in colorectal cancer". Oncology Letters 14, no. 1 (2017): 1061-1067. https://doi.org/10.3892/ol.2017.6266
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