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Review Open Access

Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)

  • Authors:
    • Guodong Deng
    • Ning Liang
    • Jian Xie
    • Hui Luo
    • Lili Qiao
    • Jingxin Zhang
    • Dawei Wang
    • Jiandong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Department of Radiation Oncology, Henan Cancer Hospital, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China, Department of Oncology, The Fifth People's Hospital of Jinan, Jinan, Shandong 250022, P.R. China, Division of Oncology, Graduate School, Weifang Medical College, Weifang, Shandong 261053, P.R. China, Department of Radiology, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 501-511
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    Published online on: May 26, 2017
       https://doi.org/10.3892/ol.2017.6268
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Abstract

Radiation-induced lung injury (RILI) remains a major obstacle for thoracic radiotherapy for the treatment of lung cancer, esophageal cancer and lymphoma. It is the principal dose‑limiting complication, and can markedly impair the therapeutic ratio as well as a patient's quality of life. The current review presents the relevant concepts associated with RILI, including the pathogenic mechanisms and the potential treatment strategies, so as to achieve a general understanding of this issue. RILI comprises an acute radiation pneumonitis phase and subsequent late lung fibrosis. The established assessment criteria are clinical manifestations, imaging changes and the necessity for medical assistance. Risk factors are also considered in order to optimize treatment planning. Due to the underlying molecular mechanisms of RILI, the present review also discusses several targeted pharmacological approaches for its treatment, as well as corticosteroid therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Deng G, Liang N, Xie J, Luo H, Qiao L, Zhang J, Wang D and Zhang J: Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review). Oncol Lett 14: 501-511, 2017.
APA
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J. ... Zhang, J. (2017). Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review). Oncology Letters, 14, 501-511. https://doi.org/10.3892/ol.2017.6268
MLA
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J., Wang, D., Zhang, J."Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)". Oncology Letters 14.1 (2017): 501-511.
Chicago
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J., Wang, D., Zhang, J."Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)". Oncology Letters 14, no. 1 (2017): 501-511. https://doi.org/10.3892/ol.2017.6268
Copy and paste a formatted citation
x
Spandidos Publications style
Deng G, Liang N, Xie J, Luo H, Qiao L, Zhang J, Wang D and Zhang J: Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review). Oncol Lett 14: 501-511, 2017.
APA
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J. ... Zhang, J. (2017). Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review). Oncology Letters, 14, 501-511. https://doi.org/10.3892/ol.2017.6268
MLA
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J., Wang, D., Zhang, J."Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)". Oncology Letters 14.1 (2017): 501-511.
Chicago
Deng, G., Liang, N., Xie, J., Luo, H., Qiao, L., Zhang, J., Wang, D., Zhang, J."Pulmonary toxicity generated from radiotherapeutic treatment of thoracic malignancies (Review)". Oncology Letters 14, no. 1 (2017): 501-511. https://doi.org/10.3892/ol.2017.6268
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